Measure Brain Toxins For Multiple Recovery Solutions
An expert is someone who has succeeded in making decisions and judgements simpler through knowing what to pay attention to and what to ignore.
~ Edward deBono
William Shaw, Ph.D., is board certified in the fields of clinical chemistry and toxicology by the American Board of Clinical Chemistry - with a profound interest in brain toxins. Before he founded The Great Plains Laboratory, Inc. in Lenexa, KS, Dr. Shaw worked for the Centers for Disease Control and Prevention (CDC), Children's Mercy Hospital, the University of Missouri at Kansas City School of Medicine, and Smith Kline Laboratories.
I've followed his work for many years, use Great Plains Laboratory for biomedical testing every day in my practice, and am exceedingly pleased to share these moments with his profound experience for our CBJ listeners. Recently Dr. Shaw added GPL-TOX to measure brain toxins to the Great Plains Labs armamentarium of essential mind tools. This CBJ Special 1-hour review will help listeners understand this possible next step for treatment failure globally.
Ed Note: Take a moment to download Dr. Shaw's Bonus Notes below ↓ with many brain toxin reference topics for further review on this essential measurement tool. This is a republication of Dr. Shaw's exceedingly popular original interview at CBJ/125 - to wrap up our New Year's Holiday Series with the CBJ Best of '17.
Dr. Shaw's Years of Scholarship Achievements
It's important to note that he is the author of two outstanding contributions to the evolution for the treatment of Autism, Biological Treatments for Autism and PDD, originally published in 1998, and Autism: Beyond the Basics, published in 2009. He is also a frequent speaker at conferences worldwide, a global authority with broad experience with the value of laboratory data and molecular insights regarding imbalanced brain functions.
On a more personal note, Dr. Shaw is the stepfather of a child with autism and has helped thousands of patients and medical practitioners to successfully improve the lives of people with autism spectrum disorders, ADHD/Executive Function, Alzheimer's disease, arthritis, bipolar disorder, chronic fatigue, depression, fibromyalgia, immune deficiencies, multiple sclerosis, OCD, Parkinson's disease, seizure disorders, tic disorders, Tourette's syndrome, and other serious conditions. References here demonstrate the depth of his understanding and life's mission.
In this interview, we discuss useful details regarding the evolution and immediate value of measurements for brain toxins about many of these conditions.
Dr. Shaw's Brain Toxins | Insights Detailed Here - CBJ/182
GPL-TOX fulfills my lifetime wish to make toxin testing available for the public [spp-timestamp time="4:49"]
90% of the people don't know specific toxin exposure and could spend $20,000 searching [spp-timestamp time="6:00"]
GPL-TOX tests for 172 different chemicals at about $200 [spp-timestamp time="6:42"]
What high values on GPL-TOX testing mean medically [spp-timestamp time="7:49"]
My first clinical case awareness on the relevance of brain toxins [spp-timestamp time="10:11"]
Carbon Monoxide can cause kleptomania and death [spp-timestamp time="12:50"]
One of the easiest things to remember about toxins [spp-timestamp time="13:22"]
Humans are the most vulnerable to brain toxins and psych problems [spp-timestamp time="14:14"]
Most common way they cause brain deterioration is through mitochondria [spp-timestamp time="15:52"]
If you're waiting for the government to monitor toxins you might as well wait for the tooth fairy [spp-timestamp time="20:20"]
The public must know: toxins cause a wide variety of mind/medical problems [spp-timestamp time="22:01"]
Details for treatment and detox [spp-timestamp time="29:58"]
Three treatments including sauna notes from 9-11 [spp-timestamp time="33:07"]
Clinical observations regarding GPL-TOX for autism [spp-timestamp time="38:40"]
Note on my recent article on glyphosate/GMO [see download below↓] [spp-timestamp time="39:40"]
Glyphosate, clostridia and HPHPA values on OATS testing- increase dopamine neurotransmitters [spp-timestamp time="44:51"]
Brain Toxin Download: For Dr. Shaw's Reference PDF - Explains GPL Test Results
The Importance of Testing for Glyphosate: The World’s Most Widely Used Herbicide
Mesnage R et al. Major pesticides are more toxic to human cells than their declared active principles. Biomed Res Int. 2014: 179691
Samsel A, Seneff S. Glyphosate, pathways to modern diseases II: Celiac sprue and gluten intolerance. Interdiscip Toxicol. 2013;6:159-184.
Samsel A, Seneff S. Glyphosate, pathways to modern diseases III: Manganese, neurological diseases, and associated pathologies. Surg Neurol Int. 2015; 6: 45.
Krüger M, Schledorn P, Schrödl W, Hoppe HW, Lutz W, Shehata AA. Detection of Glyphosate Residues in Animals and Humans. J Environ Anal Toxicol. 2014. 4:2 http://dx.doi.org/10.4172/2161- 0525.1000210
Barbosa ER, Leiros da Costa MD, Bacheschi LA, Scaff M, Leite CC. Parkinsonism after glycine-derivative exposure. Mov Disord. 2001. 16: 565-568.
Mesnage R, Defarge N, Spiroux de Vendômois J, Séralini GE. Potential toxic effects of glyphosate and its commercial formulations below regulatory limits. Food Chem Toxicol. 2015 Oct;84:133-53.
Guyton KZ, Loomis D, Grosse Y et al. Carcinogenicity of tetrachlorvinphos, parathion, malathion, diazinon, and glyphosate. Lancet Oncol. 2015 May;16(5):490-1
Shehata AA, Schrödl W, Aldin AA, Hafez HM, Krüger M. The effect of glyphosate on potential pathogens and beneficial members of poultry microbiota in vitro. Curr Microbiol. 2013 Apr;66(4):350-8.
Jayasumana C, Gunatilake S, Siribaddana S. Simultaneous exposure to multiple heavy metals and glyphosate may contribute to Sri Lankan agricultural nephropathy. BMC Nephrology 2015;16:103. doi 10.1186/s12882-015-0109-2
Jayasumana C, Gunatilake S, Senanayake P. Glyphosate, hard water and nephrotoxic metals: Are they the culprits behind the epidemic of chronic kidney disease of unknown etiology in Sri Lanka? Int. J. Environ. Res. Public Health 2014;11:2125-2147.
Clair E et al. Effects of Roundup® and glyphosate on three food microorganisms: Geotrichum candidum, Lactococcus lactis subsp. cremoris and Lactobacillus delbrueckii subsp. bulgaricus. Curr Microbiol. 2012;64: 486-491.
DeWolf WE Jr. Inactivation of dopamine beta-hydroxylase by p-cresol: isolation and characterization of covalently modified active site peptides. Biochemistry. 1988;27: 9093-9101.
Swanson NL, Leu A, Abrahamson J, and Wallet B. Genetically engineered crops, glyphosate and the deterioration of health in the United States of America. Journal of Organic Systems. 2014; 9(2):6- 37.
Environmental Protection Agency. Pesticides Industry Sales & Usage. 2006 and 2007 Market Estimates. Available at https://www.epa.gov/sites/production/files/2015-10/documents/market_ estimates2007.pdf. Accessed July 15, 2015.
Shehata AA et al. The effect of glyphosate on potential pathogens and beneficial members of poultry microbiota in vitro. Curr. Microbiol. 2013;66: 350-358.
Larsen K et al. Effects of sublethal exposure to a glyphosate-based herbicide formulation on metabolic activities of different xenobiotic-metabolizing enzymes in rats. Int J Toxicol. 2014;33: 307-318.
References to Phthalates
Silva MJ, et al. Improved quantitative detection of 11 urinary phthalate metabolites in humans using liquid chromatography-atmospheric pressure chemical ionization tandem mass spectrometry. J Chromatogr B Analyt Technol Biomed Life Sci 789:393-404, 2003.
Silva MJ, et al. Urinary levels of seven phthalate metabolites in the U.S. population from the National Health and Nutrition Examination Survey (NHANES) 1999-2000. Environ Health Perspect 112:331-338, 2004.
Silva MJ, et al. Analysis of human urine for fifteen phthalate metabolites using automated solid-phase extraction. J Chromatogr B Analyt Technol Biomed Life Sci 805:161-167, 2004.
Adibi JJ, et al. Prenatal exposures to phthalates among women in New York City and Krakow, Poland. Environ Health Perspect. 111:1719-22, 2003.
Ritter, EJ, et al. Teratogenicity of di(2-ethylhexyl)phthalate, 2-ethylhexanol, 2-ethylhexanoic acid, and valproic acid, and potentiation by caffeine. Teratology 35 (1):41-6, 1987
Ormond, G, et al. Endocrine disruptors in the workplace, hair spray, folate supplementation, and risk of hypospadias: Case-control study. Environ Health Perspect 117(2): 303–307, 2009.
References to Organophosphates
Eskenazi B, et al. Organophosphate Pesticide Exposure and Neurodevelopment in Young Mexican-American Children. Environ Health Perspect 115:792–798 (2007).
Eskenazi B, et al. Association of in utero organophosphate pesticide exposure and fetal growth and length of gestation in an agricultural population. Environ Health Perspect112:1116–1124, 2004.
Windham, GC, et al. Autism spectrum disorders in relation to the distribution of hazardous air pollutants in the San Francisco Bay area. Environ. Health Perspect., 114:1438-1444, 2006.
Laslo-Baker D, et al. Child neurodevelopmental outcome and maternal occupational exposure to solvents. Arch Pediatr Adolesc Med 158:956–961, 2004.
Windham GC, Osorio AM, et al. Female reproductive toxicology. In: Occupational and Environmental Medicine (LaDou J, ed). 3rd ed. Norwalk, CT: Appleton and Lange, Inc, 397–413, 2004.
Roberts, EM, et al. Maternal Residence Near Agricultural Pesticide Applications and Autism Spectrum Disorders among Children in the California Central Valley. .Environ Health Perspect 115:1482–1489, 2007.
D'Amelio M, et al. Paraoxonase gene variants are associated with autism in North America, but not in Italy: possible regional specificity in gene-environment interactions. Mol Psychiatry 10(11):1006–1016, 2005.
Sergiu P, et al. High levels of homocysteine and low serum paraoxonase 1 arylesterase activity in children with autism. Life Sciences 78 (2006) 2244-2248.
McCully, et al. KS Chemical pathology of homocysteine. II. Carcinogenesis and homocysteine thiolactone metabolism Annals of Clinical and Laboratory Science, 24: 27-59,1994.
Boris, M, et al. Association of MTHFR Gene Variants with Autism. Journal of American Physicians and Surgeons 9:106-108, 2004.
Brown, TP, et al. Pesticides and Parkinson's disease – is there a link? Environmental Health Perspect 114(2): 156–164, 2006.
References for Other Toxic Chemicals
Anderson ME, Kirkland KH, Guidotti TL, Rose C. (2006). A Case Study of tire crumb use on playgrounds: risk analysis and communication when major clinical knowledge gaps exist. Environ Health Perspect. 114: 1-3.
Brown DR. (2007) "Artificial Turf". Environment & Human Health, Inc.
Perera FP, Chang HW, Tang D, Roen EL, Herbstman J, Margolis A, Huang TJ, Miller RL, Wang S, and Rauh V. (2014) Early-life exposure to polycyclic aromatic hydrocarbons and ADHD behavior problems. PLos One. 9: e111670.
Zhang JJ, Han IK, Zhang L, and Crain W. (2008). Hazardous chemicals in synthetic turf materials and their bioaccessibility in digestive fluids. J Expo Sci Environ Epidemiol. 18: 600-607.
Legler, J., Fletcher T., Govarts E., Porta M., Blumberg B., Heindel JJ., Transande L. (2015) Obesity, diabetes, and associated costs of exposure to endocrine-disrupting chemicals in the European Union. J Clin Endocrinol Metab. 100: 1278-88.
Chopra V., Harley K., Lahiff M., and Eskenazi B. (2014) Association between phthalates and attention deficit disorder and learning disability in US children, 6-15 years. Enviorn Res. 128: 64-9
Moretto A. and Colosio C. (2011). Biochemical and toxicological evidence of neurological effects of pesticides: the example of Parkinson's disease. Neurotoxicology. 32: 383-91.
Elwan MA., Richardson JR., Guillot TS., Caudle MW., and Miller GW. (2006) Pyrethroid pesticide-induced alterations in dopamine transporter function. Toxiocol Appl Pharmacol. 211: 199-97.
Steventon GB., Waring RH., and Williams AC. (1990) Pesticide toxicity and motor neuron disease. J Neurol Neurosurg Psychiatry. 53: 621-622.
Lowenstein J. (2014) Agent Orange and Heart Disease: Is there a connection? FASEB J. 28: 1531-1533.
Goldner WS., Sandler DP., Yu F., Shostrom V., Hoppin JA., KamelF., LeVanTD. (2013) Hypothyroidism and pesticide use among male private pesticide applicators in the agricultural health study. J Occup Environ Med. 55: 1171-1178.
Kim JS., Lim HS., Cho SI., Cheong HK., and Lim MK. (2003) The impact of Agent Orange exposure among Korean Vietnam veterans. Ind Health. 41: 149-157.
Heck JE., Park AS., Qiu J., Cockburn M., and Ritz B. (2014) Risk of leukemia in relation to exposure to ambient air toxins in pregnancy and early childhood. Int J Hyg Environ Health. 217: 662-668.
References for Mitochondrial Disorders
Poling JS, Frye RE, Zimmerman AW, et al. Developmental regression 1. and mitochondrial dysfunction in a child with autism. J Child Neurol 2006;21(2):170-172.
Poling JS. Father: Child's case shifts autism debate. The Atlanta Journal-2. Constitution. April 11, 2008.
Oliveira G, Diogo L, Oliveira CR, et al. Mitochondrial dysfunction in 3. autism spectrum disorders: A population-based study. Dev Med Child Neurol 2005; 49 (10):726-733.
Nissenkorn A, Zeharia A, Lev D, et al. Multiple presentation of 4. mitochondrial disorders. Arch Dis Child 1999;81:209–214.
Not Your Mother's Mitochondrial Disease. Myths & Facts About 5. Mitochondrial Cytopathies By Sumit Parikh, M.D. & Bruce H. Cohen, M.D. Cleveland Clinic website electronic brochure. http://my.clevelandclinic.org/disorders/Mitochondrial_Disease/
Weissman JR, et al. Mitochondrial Disease in Autism Spectrum Disorder 6. Patients: A Cohort Analysis. PLoS ONE 3(11): e3815. doi:10.1371/journal.pone.0003815, 2008.
Gibson KM, Elpeleg ON, Jakobs C, Costeff H, Kelley RI. Multiple 7. syndromes of 3-methylglutaconic aciduria. Pediatr Neurol. 1993 Mar-Apr;9(2):120-3.
Rossignol DA, Bradstreet JJ. Evidence of Mitochondrial Dysfunction in 8. Autism and Implications for Treatment Am J of Biochem Biotech 4(2): 208-217, 2008.
Filiano JJ, Goldenthal MJ, Rhodes CH, Marin-Garcia J. Mitochondrial 9. dysfunction in patients with hypotonia, epilepsy, autism, and developmental delay: HEADD syndrome. J Child Neurol., 17:435-439, 2002.
Pons R, Andreu AL, Checcarelli N, et al. Mitochondrial DNA 10. abnormalities and autistic spectrum disorders. J. Pediatr., 144:81-85.
Serajee FJ, Zhang H, Huq AH. Prevalence of common mitochondrial 11. point mutations in autism. Neuropediatrics, 37 (Suppl 1):S127, 2006.
Weissman JR, Kelley RI, Bauman ML, Cohen BH, Murray KF, et al. 12. (2008) Mitochondrial Disease in Autism Spectrum Disorder Patients: A Cohort Analysis. PLoS ONE 3(11): e3815. doi:10.1371/journal.pone.0003815.
González L, et al. Endoscopic, histologic, and immunologic characteristics of the digestive mucosa in autistic children with gastrointestinal symptoms. Archivos Venezolanos de Puericultura y Pediatria. 2005;69(1):19-25.
Windham GC, Zhang L, Gunier R, Croen LA, Grether JK. Autism 14. spectrum disorders in relation to the distribution of hazardous air pollutants in the San Francisco Bay area. Environ Health Perspect. 2006 Sep;114(9):1438-44.
Gash DM, et al. Trichloroethylene: Parkinsonism and complex 1 15. mitochondrial neurotoxicity. Ann Neurol. 2008 Feb;63(2):184-92.
Freed DM, Kandel E. Long-term occupational exposure and the 16. diagnosis of dementia. Neurotoxicology 1988 ;9(3):391-400.
Bennett MJ, Powell S, Swartling DJ, Gibson KM. Tiglylglycine Excreted 17. in Urine in Disorders of Isoleucine Metabolism and the Respiratory Chain Measured by Stable Isotope Dilution GC-MS. Clin. Chem. Vol. 40, No. 10, 1994 1879-1883.
Ibel H, Endres W, Hadorn HB, Deufel T, Paetzke I, Duran M, Kennaway 18. NG, Gibson KM. Multiple respiratory chain abnormalities associated with hypertrophic cardiomyopathy and 3-methylglutaconic aciduria. Eur J Pediatr. 1993 Aug; 152(8):665-70.
Gibson KM, Elpeleg ON, Jakobs C, Costeff H, Kelley RI. Multiple 19. syndromes of 3-methylglutaconic aciduria Pediatr Neurol. 1993 Mar-Apr;9(2):120-3.
Scaglia F, Sutton VR, Bodamer OA, Vogel H, Shapira SK, Naviaux 20. RK, Vladutiu GD. Mitochondrial DNA depletion associated with partial complex II and IV deficiencies and 3-methylglutaconic aciduria. J Child Neurol. 2001 Feb;16(2):136-8.
Barshop B. Metabolomic approaches to mitochondrial disease: 21. correlation of urine organic acids. Mitochondrion 4: 521-527, 2004.
What's Wrong in Toms River? By Sucato K. The New York Times, 22. Sunday, December 16, 2001, Section 14NJ page 1 of the New York edition.
Olick D, reporter. CBS Evening News: Town Mulls Autism Mystery. 23. Thursday, January 21, 1999. Copyright 1999, CBS Worldwide Inc.
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Until next time, thanks so much for joining us here at CBJ again. Have some feedback you’d like to share? Leave a note in the comment section below. If you enjoyed this episode, please share it using the social media buttons you see at the bottom of the post.
In closing, if you have any questions, drop a comment on any posting here at CBJ, and I’ll get back to you. This discerning show of world-class experts is here for you, your families, and your clients - to tighten the dialogue for more precise answers.
And finally, don’t forget to subscribe to the show on iTunes to get automatic updates, or if you’re on an Android Device subscribe for timely updates at Google Play. Yes, these extraordinary experts with years of experience are free.
Special thanks, Dr. Shaw for your fresh, data-driven brain toxin insights to reconsider how laboratory measures can reveal abundant details for clinical options to address treatment failure in multiple brain and biomedical conditions. Your additional bonus references take your interview insights into global immediacy. Thank you from all of us for all of your extraordinary work on so many levels over the years.
Next CoreBrain Journal Guest
183 Natasha Trenev - As a developmental scientist, health activist, and internationally renowned probiotic authority, Natasha Trenev has spent years studying the effects of beneficial bacteria and has written several books on the subject. Co-founder of Natren, Inc., she is a member of the American Society of Microbiology, American Association for the Advancement of Science, Institute of Food Technologists, Anaerobe Society of the Americas, and the American Dairy Science Association.
She's considered "The Mother of Probiotics." Her considerable accomplishments will appear in her CBJ/183 show notes and confirm this accolade.
Following her graduation from UCLA in 1970, a decade of research led to Natasha’s development of the first revolutionary method of producing an effective and scientifically validated single strain probiotic bacteria product. Her efforts led to the establishment of the entire probiotics category in North America, Australia, England, Holland, and Belgium.
Her interesting views on probiotic specificity are, in a word, remarkable.
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