In this episode, we uncover the question, is the "cholinergic anti-inflammatory reflex" nerves entirely vagal? The answer is not so straightforward. Building on good work by Davide Martelli and Robin McAllen, we uncover crucial role of the efferent arm of the reflex to "also" be sympathetic.
And at the end, we also talk about the importance of understanding the referral and implantation pathway and why we remain muted in the ability of neuromodulation for immune-inflammation to be uptaken widely anytime soon.
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