042 Biomedical Markers Bipolar & Schizophrenia Dr Walsh-3
Biomedical Markers Reviewed For Bipolar and Schizophrenia
- The CoreBrain Journal Walsh Molecular Series: 3 of 4 -
Abnormalities in methylation and folate chemistry are common in schizophrenia, bipolar disorder, depression, anxiety, and certain behavioral disorders.
The most common phenotype of schizophrenia involves elevated dopamine activity, and most current antipsychotic medications are aimed at lowering activity of this neurotransmitter. Unfortunately, this is the wrong approach for schizophrenics with different brain chemistry. Most efficacy experiments for depression and schizophrenia continue to involve a mixture of disorders with different brain chemistry imbalances. This blurs the data and weakens the scientific findings. Some psychiatry experts have recently urged researchers to develop objective tests for separating these illnesses into meaningful phenotypes.
Biomedical markers, specific molecular measures, change the rules of the diagnostic and treatment game. Why? Improved target recognition for contributory molecular mind variables offers increased precision and more predictable outcomes. It's an honor for me, and for our serious team at CoreBrain Journal, to welcome Dr. Walsh for this third in a special series of three one-hour CBJ indispensable interviews.
If you're a regular at CBJ, you will, with this CBJ/042 Episode, now understand the reason for the sequence of this Walsh three-part series. Each perspective builds on the other, and in this interview, Dr. Walsh effectively ties together connections between CBJ/025 and CBJ/034.
Why one hour for these interviews? - Because Bill's imperative message introduces fresh workable possibilities:
Fresh, Relevant Data in a rapidly rising sea of excellent biomedical insights improves mind measurement and treatment initiatives for many who suffer from treatment failure.
Cost Effective Measures now reveal patterns of previously under-appreciated brain functions that look on the surface as untreatable - e.g. personality disorders, autism, mood disorders, schizophrenia, cognitive deterioration, ADHD. - More biomedically precise than SPECT imaging.
Understandable insights that lead to specific biomedical resolution strategies. Read his book. His molecular view arrives in different language packaging, and yet translates into informed, effective clinical care for many.
About Dr. Walsh and Biomedical Markers
William J. Walsh, Ph.D., FACN, president of the non-profit Walsh Research Institute, is an internationally recognized expert in the field of nutritional medicine and a key scientist paving the way for nutrient-based psychiatry and nutritional medicine. Over the past 30 years, Dr. Walsh has developed biochemical treatments for patients diagnosed with behavioral disorders, attention deficit (hyperactivity) disorder, autism, clinical depression, anxiety, bipolar disorders, schizophrenia, and Alzheimer’s disease that are used by doctors throughout the world.
Dr. Walsh’s noted accomplishments include: (a) groundbreaking studies reporting reduced violent behavior following nutrient therapy, (b) the 1999 discovery of undermethylation[CBJ/025] and copper/zinc imbalances[CBJ/034] in autism, (c) the 2000 finding of metallothionein protein depletion in autism, (d) the 2007 published study linking copper overload and post-partum depression, (e) the identification of five biochemical subtypes of clinical depression, (f) the 2011 development of the Walsh Theory of Schizophrenia, and (g) the direction of the Beethoven Research Project that revealed that the composer suffered from severe lead poisoning.
His internationally acclaimed presentations, including for the American Psychiatric Association, affirm his significant contributions to both functional and traditional medical groups.
[caption id="attachment_2860" align="alignright" width="300"] Parker and Walsh at our first meeting: ACAM 2013[/caption]
After earning degrees from Notre Dame and the University of Michigan, Dr. Walsh received a Ph.D. in chemical engineering from Iowa State University. While working at Argonne National Laboratory in the 1970s, Dr. Walsh organized a prison volunteer program that led to studies of prisoners and ex-offenders researching the causes of their violent behavior.
His collaboration with renowned (late) Carl C. Pfeiffer, MD, Ph.D., a pioneer in the field of nutritional research therapy, led Dr. Walsh to the development of individualized nutrient protocols to normalize body chemistry and brain chemistry. Dr. Walsh went on to study more than 30,000 patients with mental disorders acquiring an unparalleled database of more than 3 million chemical assays during his clinical and research work.
N.B.: Dr. Walsh has conducted chemical analysis of more than 25 serial killers and mass murderers, including Charles Manson, Richard Speck, James Oliver Huberty, Patrick Sherrill and Arthur Shawcross. He has assisted medical examiners, coroners, Scotland Yard, and the FBI with these biomedical markers for forensic studies. He has designed nutritional programs for Olympic athletes, NBA players, major league baseball players, a heavyweight boxing champion, PGA and LPGA golfers, and others.
My analysis of blood and urine testing of 3,600 persons diagnosed with schizophrenia has confirmed Pfeiffer’s finding of three distinct chemical classifications or phenotypes that represent 90% of the cases: over methylated schizophrenia (42%), undermethylated schizophrenia (28%), and a condition of severe oxidative stress termed pyrrole schizophrenia (20%). Each phenotype involves a distinctive constellation of symptoms and traits that can assist in diagnosis. [1-pg 55]
Methylation is a biochemical process of extraordinary importance in human functioning. It may be defined as the addition of a methyl group (CH3) to an atom or molecule. Methyl groups participate in dozens of chemical reactions in the body and brain that are essential to physical and mental health. In addition, methylation status is a major factor in a person’s personality and traits. For example, undermethylation is associated with perfectionism, strong will, high accomplishment, OCD tendencies, and seasonal allergies. Typical features of overmethylation include excellent socialization skills, many friendships, non-competitiveness, artistic or musical interests, chemical and food sensitivities, and a tendency for high anxiety. 
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043: Bart Rossi Ph.D. is a political psychologist commentator that provides insights to stories in the news on TV and print. He offers psychological insight to high profile news items in general, and politics in particular. He has appeared on a broad range of television networks, including MSNBC, CBS, and FOX5, local television MY9, PIX 11, and the cable news shows News12: Power and Politics; and the EMMY-winning cable show The Fresh Outlook. He's opinionated on the world scene from a psychologist's perspective and doesn't hesitate to tell you his insights from the available records on either candidate. Listen up!
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