Just when the Borgias seem at the top of their game and that nothing could possibly stop them, in August of 1503 pope Alexander VI, after a dinner party at a cardinal's house, becomes seriously ill and died after two weeks.

His son Cesare also becomes very ill and cannot sum up the energy to control the fallout of the situation and outmanoeuvre the Borgia's arch enemy, cardinal Giuliano della Rovere.

In the end the inevitable happens and he becomes pope Julius II, sealing the impeding doom of Cesare Borgias who, after some time in captivity, seems to take the option of going out in a blaze of glory.