In today's podcast, we're going to look at boron and cardiovascular disease. Risk factors for cardiovascular diseases may be noticeably improved by the intake of boron-containing compounds.

In particular, these compounds reduce blood pressure, improve cholesterol levels and reduce inflammation.

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In today's podcast, we're going to look at boron and cardiovascular disease.

Risk factors for cardiovascular diseases may be noticeably improved by the

intake of boron containing compounds.

In particular, these compounds reduce blood pressure, improve cholesterol

levels and reduce inflammation.

Boron and Cardiovascular Disease

Boric acid and borates are boron containing inorganic

compounds found in soils.

Plants and bacteria use them to produce all known boron

containing organic compounds.

These organic compounds are often used in cell metabolism in humans, where they

are partially converted into boric acid.

The boric acid is then excreted as waste from the body.

Compared with their organic counterparts, inorganic organic boric acid and

borates have significantly different chemical and biochemical properties.

The biochemical activities of compounds that contain boron differ greatly

depending on the organic ligans used and the binding constant of boron

compared to any specific molecule.

It has been recognized that boron deficiency in soils, which leads

to BCC depletion, boron containing compounds, depletion, and fruits and

vegetables in the food supply, is associated with a higher occurrence

of arthritis, and inflammatory disease also linked to cardiovascular health.

The term cardioprotection refers to all methods of

preserving cardiovascular health.

Perhaps the most important is nutrition.

The typical Mediterranean diet, which includes BCC rich stable foods ensures

a total PCC consumption of even more than 13 milligrams of boron per day per

person, though as little as one milligram of boron per day per person is presently

assumed to provide health benefits.

The hypothesis is that the cardiovascular protection provided by Mediterranean

diets is guided more by the types and varieties of BCCs that provide

specific biochemical activities relating to cardiovascular health than the

simple total elemental boron content.

Boron containing compounds regulate enzymatic activity.

They interact with enzymes, from microorganisms, plants, animals and

humans likely to result in enzyme activation, stabilization and inhibition.

In human cells.

BCC's activities involved in the regulation of specific enzymes, the

binding of particular receptors, m RNA splicing and inducing apoptosis.

Furthermore, boron stabilizes the phosphatase alkaline enzyme

through some reactions present preventing oxidative stress.

Besides that, boron containing molecules, improve the resistance of

hemeproteins to denaturation, which may have cardioprotective effects due to

their peroxide induced stabilization.

It was recently discovered that the fluoroborate complex is a powerful

catalyst in various biological reactions in plants and may function as a coenzyme.

In addition to the benefits for cardiovascular health and joint health,

cognitive function, bone density and prostate health, researchers have started

examining BCC's value as an antioxidant.

In one study, researchers looked at the effects of BCC, such as

calcium fructoborate on skin wounds.

They investigated whether CFB had antioxidant properties

in human keratinocytes cultures, (human skin cells).

CFB treated cells were exposed to exogenous hydrogen peroxide to recreate

environmental induced oxidative stress.

The results showed that CFP limited the development of intra cellular reactive

oxygen species, implying that CFP may have superoxide dismutase that could

be clinically relevant in protecting cells from oxidation induced damage.

Furthermore, previous research suggested that aboron rich rich diet may boost

the enzyme activity by the SOD pathway.

Extra cellular SOD is also known to protect against atherosclerosis,

against hypertension and heart failure and diabetes mellitus.

All of these analyses yields the role of oxidative stress

in cardiovascular disease.

What are the Factors in Cardiovascular Disease?

Number one.

Beneficial effects of BCC'd on plasma lipids mainly were observed in animal

studies where sodium borate consumed directly caused a significant decline

in overall cholesterol lipoprotein fractions and triglyceride levels.

However, other authors would not confirm such effects and an undesirable HDL

cholesterol reducing impact was found.

They also looked at how a four week BA supplementation affected rat

steroid hormones and plasma lipids.

After two weeks, boron containing compound supplementation caused a

reduction in plasma, TG and total HDL cholesterol concentrations.

After another month, the HDL cholesterol was the only

dramatically lowered parameter.

Other animal studies have also observed a negative or neutral effect.

According to some studies, adding boron to layer diets could significantly reduced

total plasma lipids, cholesterol, and LDL.

while enhancing HDL.

Hens were fed a basal diet with just a relation of 200

milligrams of boron per kilogram.

These had the least overall lipids, cholesterol, and LDL.

The concentration levels of total cholesterol, triglycerides,

high-density lipoprotein, (HDL), low density lipoprotein.

(LDL), very low density, lipoprotein, (VLDL), glucose, insulin, and non

esterified fatty acids, all decreased after sodium tetraborate administration.

Because boron containing compounds can have different specifications

depending on chemical structure, the contradictory results could be evidence

of boron speciation in animal metabolism.

How about Boron-containing Compounds and Diabetes?

Diabetes mellitus and other glucose metabolism illnesses are major risk

factors for cardiovascular disease.

Backen and Hunt, in a study devised an analysis to find the influence

of BCC as BA on insulin release.

They discovered considerably higher plasma insulin concentrations in

rats, deficient in boron but no change in plasma glucose levels.

Dietary magnesium or vitamin D levels did not influence this effect.

Furthermore, boron deprived chickens had vastly greater peak insulin values

than those fed physiologic amounts.

As a direct result, boron did not affect peak incident action or pancreatic mass.

These results indicate the BCC's may reduce the amount of insulin

necessary to keep glucose homeostasis.

Boron in some form could reduce plasma, insulin, concentration

levels with no close link to vitamin D or magnesium status.

Another study on 30 Sprague Dawley rats fed BA and borax supplemented diet

with a dose of a hundred milligrams of Borum per kilogram found a reduction

in leptin, insulin and glucose levels.

Bodyweight reduced, probably due to a rise in T3, thyroid hormone level.

Borax had the more significant effect of the two compounds tested.

A Third Area is the Effects of BCC's on Smoking Risk.

Tobacco use is considered an epidemic and a major public health threat by the

WHO, and one of the most significant risk factors for cardiovascular disease.

The primary components released by smoking are nicotine and carbon

monoxide, which promote oxidative stress, endothelial damage and dysfunction.

It also raises serum total cholesterol and triglyceride levels, decreasing,

cardioprotective HDL, and fosters intravascular inflammation,

all of which are risk factors for developing arthrosclerosis

and cardiovascular disease.

Tobacco Products

Tobacco products involve a slew of potentially toxic molecules, the

most cytotoxic of which is nicotine.

Diets high in boron containing compounds were linked to a lower risk of cervical

cancer, prostate cancer, and lung cancer in women who smoked heavily.

Furthermore, high quality BCC intake has been linked to lower lung cancer risks in

smokers whereas the highest risk is found in smokers who lack hormone replacement

therapy and have a low boron intake.

Recent research shows that the antioxidant properties of BA

protected DNA and decreased nicotine induced cytotoxicity in vitro.

These findings raise the possibility that natural BCC's may also have the ability to

counteract the adverse effects of smoking.

How About Boron-containing Compounds as an Aging Risk Factor?

Oxidative stress is among the systems involved in the aging process.

This happens when the production and disposal of reactive oxygen

species are out of balance.

It was recently discovered that low doses of numerous boron containing

compounds can enhance antioxidant capacity by adding enzymatic activities.

Furthermore, PCCs may hinder Maillard's reactions.

This is accomplished by stabilizing borate esters on furanose rings with cis-diol,

which enables the chemical evolution of sugar and amino acids in aqueous media.

As a result, this could aid in regulating the aging process.

And that's all from Borates Today.

For more information on boron and cardiovascular disease, please

refer to Borates Today, website.