The Prescribe Safe Initiative is an extremely successful community-based project bringing together law enforcement, hospitals and physicians to reduce prescription medication misuse. The American Hospital Association and the AHA Physician Alliance sought to provide members with a deeper dive on key elements driving the success of Prescribe Safe through three podcasts that explore: • Securing funding and support, • Working collaboratively with a wide variety of partners; and • Leveraging complementary and alternative medicine to reduce the use of opioids in the management of pain. For additional information and resources on how hospitals and health systems are impacting the opioid epidemic go to: www.aha.org/opoiods