Accurate data, analytics and impassioned and inquisitive leaders are all important drivers of a strong patient safety mission for any health care organization. In this conversation, Mindy Estes, M.D., former CEO of Saint Luke's Health System and former AHA board chair, and Tori Bayless, CEO of Luminis Health and AHA board member, discuss how hospital leaders and boards can drive meaningful change, the impact of data-driven decision making, and the importance of mentoring future health care leaders.