Shownotes
Concepts in this episode
Ryan and Toxo introduce their roles while explaining the current state of toxicology and what exactly a poison is.
testing our tests
- Sensitivity: Rate of Positive test in those who have the disease
- Specificity: Rate of negative test in those without the disease
- Positive predictive value: True positive/ True Positive + False Positive
- Negative predictive value: True negative/True negative + False negative
Pharmacokinetics and dynamics
- (PK) Bioavailablity = Amount of drug available to be used by the body
- Oral Bioavailablity= Dose- Fraction excreted unchanged- Fraction metabolized in gut- Fraction metabolized by liver
- How drugs interact with the body (PD)
- Agonist- stimulates receptor
- Partial agonist- Activation of receptor with ceiling effect, never achieves maximal activation
- Antagonist- Prevents receptor activation
- Inverse agonist- induces an opposite effect as an agonist after binding receptor
- Addiction vs dependance
- Addiction- Relationship between user and substance
- A few definitions but frequently involving consequences in life from use and loss of control over use of substance
- Dependence- Physiologic changes in body due to chronic use
- Down regulation of stimulated receptors
- Physiologic basis for tolerance and withdrawal
