Spray drying is used in various pharmaceutical applications and has become an increasingly popular technique in the production of formulations of poorly soluble APIs and inhalable dry powder formulations. This remarkable technology involves spraying a liquid formulation through a nozzle creating small droplets that dry and produce a powder in one single step.

In pharmaceutical manufacturing, spray drying is suited to the production of peptides, proteins, and poorly water-soluble APIs, because it allows them to be co-processed with amorphous form stabilizers or solubility enhancement excipients. Another advantage is that the approach reduces the number of unit operations, potentially lowering manufacturing costs.

In this podcast interview with Stefano Console, Senior Advisor and Founder at Oriento, we explore how spray drying can overcome the problem of low bioavailability that all too often stalls clinical testing programmes as well as how it can help in drying and formulating biologics compounds.