Dr. William Brennan describes EMBARK, a transdiagnostic flexible model of psychedelic facilitation that builds on existing approaches in clinical research of psychedelic-assisted therapy. He describes the six clinical domains and four care cornerstones, and how they can be flexibly applied to a range of conditions and settings. We discuss some of the pros and cons of a unifying model of change in psychedelics, as well as the tension between individualism in psychotherapy with a systemic, contextual understanding of mental health problems.