This episode discusses an article titled “The MMP14–caveolin axis and its potential relevance for lipoedema,” published in Nature Reviews Endocrinology in August 2020 by research groups in Germany and Texas. The study aims to uncover the root cause of lipedema and suggests a potential mechanism involving the dysregulation of the CAV1 protein and the MMP14 enzyme. This research provides insights into how these molecular players may explain the primary features of lipedema.