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Why L-Arginine and L-Citrulline Do Not Increase Nitric Oxide
Episode 29322nd July 2025 • Sexual Health For Men • Dr. Anne Truong
00:00:00 00:09:25

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Why are your nitric oxide levels still low even after taking L-arginine and L-citrulline every day?

If you're doing all the “right” things but still not seeing results, there's a deeper issue at play that most people completely miss. In this episode, we take a closer look at why nitric oxide production can stall, even with popular supplements. We also explore a key enzyme that may be holding you back. Plus, you’ll hear why your age, digestion, and even your daily habits could be quietly sabotaging your efforts.

Don’t miss this eye-opening conversation. Tune in now and learn what it really takes to boost nitric oxide naturally.

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For all links and resources mentioned on the show and where to subscribe to the podcast, please visit https://sexualhealthformenpodcast.storychief.io/boost-nitric-oxide-naturally-without-supplements

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Transcripts

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This podcast is for you, the Modern Man. I'm Dr Anne Truong,

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your host. I'm an intimate health medical doctor and best

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selling author of the book, Erectile Dysfunction Fix. I'll

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do a deep dive into sexual health and performance and how

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it affects men of all ages and backgrounds. So let's get

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started, and be sure to visit my website at

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sexualhealthformenpodcast.com for more information and

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resources from the show. See you on the inside.

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I get this question a lot, "I keep taking L-arginine,

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L-citrulline, my nitric oxide doesn't get better, and I'm

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still deficient in nitric oxide." In my last episode, I

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talked about how you can measure nitric oxide by using the nitric

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oxide strip. But if you keep taking the L-arginine, L

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citrulline, and you don't see an improvement, that's why we're

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going to talk about it today, because I don't want you to

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waste your money and get frustrated, because there are

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multiple reasns why you will not make nitric oxide by taking

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L-arginine or L citrullate, and that your diet is the best thing

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possible. So stay with me ob this. We're going to get a

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little nerdy. We're going to get into the size of it a little

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bit, but just stay with me, and I'm going to try to explain to

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you why taking L-arginine, L-centulline does not increase

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your nitric oxide.

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First of all, is a first pass metabolism in your gut and your

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liver. A significant portion of the supplement that you take

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that has L-arginine, L-citrulline in it get

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metabolized and it doesn't go to the bloodstream once it go to

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your stomach and goes to the liver. So the liver and the gut

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kind of decrease the amount of bioavailability for even your

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body to even convert it to nitric oxide. Now, in order for

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your body to convert nitric oxide, you need the system

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called NOS. NOS means nitric oxide synthase. What nitric

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oxide synthase is kind of like an enzyme that has to convert

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the L-citrulline, L-arginine to nitric oxide. But if that enzyme

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is not working well, no matter how much L-arginine,

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L-citrulline you take, it will not convert it, because that

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enzyme is not going to make you nitric oxide. So you can have a

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gazillion L-arginine, L-citrulline sitting here, the

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enzyme is not going to convert it to nitric oxide. And in fact,

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when you have that much L-arginine, L-citrulline, it

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will actually become something that is inflammatory. It will

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actually decrease blood flow, which is the opposite of what

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you want to take, and may even harm your erection. So in most

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individual, taking L-arginine, you will not make nitric oxide

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because your enzyme, in what's called is saturated, no longer

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working well. That's called the L-arginine paradox, and that the

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nitric oxide synthase enzyme depends upon many, many factors.

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I'm not going to go over and board you, but it depends on a

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lot of vitamins and co-factors. That's why most of the time it

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doesn't work well. By the time you're 40, 50% of the NOS system

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is actually not even effective at all too. So just want you to

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let you know that by time you're 40, you've lost about 50% the

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ability to make nitric oxide. And that if you take too much

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nitric oxide, it will become inflammatory, and it will

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actually decrease blood flow as well, too.

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So in context, I hope you understand that if your enzyme

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is not working, then you're not making nitric oxide. So the best

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thing is to take it from your diet, and on this slide that I'm

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showing you, is going to talk about the two systems that I

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talk about, the NOS system which is on the left side, which it

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depend upon the enzyme, and then from your diet, because if you

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take, like arugula or beet and take sunflower seed, it will go

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to your mouth, and then your bacteria will convert it, and

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also the gastric acid in your stomach will convert it to

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nitric oxide. So you know that your enzyme is going to be

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deficient 50% of the time. Try to get your nitric oxide from

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your diet to increase your nitric oxide, and that's one of

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the reason why we created the nitric oxide capsule here that

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has arugula extract and no L-aginine, L-citrulline because

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it gives you the arugula straight into your system

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without your NOS enzyme having to convert it. So it gives you

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straight your nitric oxide. I that you need to increase blood

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flow. And therefore, if you're taking L-citrulline, L-arginine,

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and you're not having increase in nitric oxide, that is the

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reason why, because you're NOS enzyme is not working well, and

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that you need to supplement it through diet. And also I talked

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about in my previous episode, breathing. Breathing exercises

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where you breathe into your nose, breathe in for count of

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four and breathe out for a count of six, will also increase

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nitric oxide. Also exercise, such as doing weight training or

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high intensity interval exercise, will also increase

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your nitric oxide. So just simple things like that will go

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a long way, rather than taking L-citrulline, L-arginine,

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because it depended upon the enzyme system NOS, which is

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really not working that well. Also strategies that I talked

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about in the past episode, you can check out here where, you

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know, avoid taking fluoride mouthwash or fluoride

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toothpaste, and decrease the amount of antacid that you need

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to take. So that goes a long way, and I hope that will save

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you some money in taking the L-arginine, L-citrulline.

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Let me know what you think about this. And I'm hoping just to

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save you guys some money and make sure that you measure your

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nitric oxide with the strip here I'm deficient so I take my

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nitric oxide capsule of arugula extract every day. You can find

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that in our store at ednomore.com, the link down

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below here. And just know that you are worth it. You are not

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broken, and do not have to suffer with ED at this time. So

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that's one of the reason why I created the Get Wood Now course,

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check the link down below to show you some ED breakthrough

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strategies so that way you can have sexual confidence again.

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And if you need a community of men that has ED, that want to

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break out of ED, is supported by me, my coaching program called

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not alone, you do not have to suffer in silence, and there are

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Having said that, I hope you enjoyed this episode. I will see

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you in the next one, Modern Man.

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Okay, Modern Man, you are not alone and you don't have to

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suffer anymore. ED can feel isolating, frustrating, and even

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get this journey started together. Check out the course

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at getwoodnow.com. I'll see you there.

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Thanks for listening to the Sexual Health for Men Podcast.

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If you love this episode, then please take a screenshot on your

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incredible free gift designed to help you improve performance

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can have sexual vitality for life. I appreciate you until

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next time.

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