In this episode, we're diving into Skin Cancer Awareness Month with a focus on melanoma and the science moving faster than ever. Colette brings an update on a treatment she covered in Episode 74, plus two more breakthroughs in melanoma care.

Leah returns to a conversation we started last year with Dr. Michael Caney of CarThera, with new developments on their SonoCloud® technology. Leah discusses the advancments of the Sonocloud into its phse 3 trial.

Julia covers the latest in bladder cancer research, including a brand-new drug developed right here in California.

Elevate Society Review

Resources & Clinical Trials

• Melanoma Research Foundation Trial Finder: melanoma.org/clinical-trial-finder

• ClinicalTrials.gov — search 'melanoma' or 'bladder cancer' for currently enrolling studies

• UC Davis Bladder Cancer Trial: bcan.org/clinicaltrials/plz4-coated-paclitaxel-loaded-micelles-for-the-treatment-of-patients-with-recurrent-or-refractory-non-muscle-invasive-bladder-cancer

• CarThera SONOBIRD Trial: sonobird.eu |NCT05902169

Sources

Colette's Segments — Melanoma

• American Cancer Society Cancer Statistics Report, Jan 2025: https://www.cancer.org

• Cancer Health — mRNA Vaccine 5-Year Follow-Up, Jan 2026: https://www.cancerhealth.com

• ASCO 2025 Annual Meeting Abstracts: https://www.asco.org/meetings/2025

• Melanoma Research Foundation 2025 ASCO Recap: https://melanoma.org

• FDA Accelerated Approval — Lifileucel (Amtagvi), Feb 16, 2024: https://www.fda.gov

• Let's Talk F*ng Cancer — Ep. 74 (Lifileucel original coverage, May 2025): https://podcasts.apple.com/us/podcast/lets-talk-f-ng-cancer/id1697931310?i=1000708495074

Leah's Segment — CarThera

• CarThera Research & Development Pipeline: https://carthera.eu/research-development/

• SONOBIRD Phase 3 Trial — ClinicalTrials.gov NCT05902169: https://clinicaltrials.gov/study/NCT05902169

• SONOKID Pediatric Trial — ClinicalTrials.gov NCT05293197: https://clinicaltrials.gov/ct2/show/NCT05293197

• SONIMEL Melanoma Brain Metastases Trial — ClinicalTrials.gov NCT04021420: https://clinicaltrials.gov/ct2/show/NCT04021420

Julia's Segment — Bladder Cancer

• Cleveland Clinic — Bladder Cancer Overview: https://my.clevelandclinic.org/health/diseases/14326-bladder-cancer

• Memorial Sloan Kettering — Bladder Cancer Treatments: https://www.mskcc.org/cancer-care/types/bladder#what-are-the-treatments-for-bladder-cancer-

• UC Davis Health — New Drug Offers Hope to Bladder Cancer Patients, Nov 2025: https://health.ucdavis.edu/news/headlines/new-drug-developed-at-uc-davis-offers-hope-to-bladder-cancer-patients/2025/11

• Michigan Institute of Urology — Bladder Cancer Without Bladder Removal: 2026 Options: https://www.michiganurology.com/bladder-cancer-without-bladder-removal-your-2026-options-blog/

⚠️ Medical Disclaimer

The information shared in this episode is for educational purposes only and does not constitute medical advice. Always consult a qualified healthcare provider regarding any medical conditions, diagnoses, or treatment options.