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Why Your Gut Is Running Your Immune System (And What to Do When It’s Not Working)
Episode 1152nd March 2026 • The Goode Health: Functional Medicine, Longevity & Autoimmune • Nicole Goode Certified Functional Medicine Practitioner
00:00:00 00:21:48

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Your gut isn’t just digesting food, it’s directing your immune system. Around 70% of your immune cells live in the gut, and when that relationship becomes disrupted, the consequences ripple far beyond digestion. In this episode, we break down the gut-immune axis and explain why symptoms like fatigue, brain fog, recurrent infections, skin flare-ups, IBS, and autoimmune disease often trace back to gut dysfunction.

03:15 – What Is the Gut-Immune Axis? (70% of Your Immune System Lives in Your Gut)

05:00 – The Gut Barrier & Increased Intestinal Permeability (“Leaky Gut”)

06:50 – The 6 Biggest Gut-Immune Disruptors

10:40 – How Stress, Sleep & the Microbiome Create a Vicious Cycle

12:40 – Signs Your Gut-Immune Axis Is Under Stress

14:30 – Why Fatigue, Brain Fog & Low Mood Can Be Immune-Driven

15:40 – The Functional Medicine 4R Protocol for Gut Repair

18:30 – Key Nutrients for Gut Lining Repair & Immune Regulation

19:45 – Why You Can’t Heal the Gut Without Addressing Chronic Stress

If you’re tired of managing isolated symptoms and want to understand the root cause behind immune dysfunction, this episode joins the dots and shows you where to start.

RESOURCES: Grab all the links and resources mentioned in this episode at https://www.nicolegoodehealth.com/the-goode-health-podcast/episode-115

DISCLAIMER: The content in this podcast and related website is not intended to be a substitute for medical advice. It is not intended to be used to diagnose or treat, instead it is designed to help educate and inspire. Always seek the advice of a professional medical practitioner or qualified health practitioner. Never ignore or disregard advice given to you based on information in this podcast or related website and do not delay in seeking medical advice.

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