Dr. Karen Knudsen, CEO of the Parker Institute for Cancer Immunotherapy (PICI), joins Dr. Sean Khozin to dissect the science and business of curing cancer. From her upbringing as a self-described "nomad" and "army brat" to leading the American Cancer Society, Karen shares her journey from the lab bench to the boardroom.

In this episode, we explore the Parker Institute's unique model of "venture philanthropy." Karen explains how PICI uses shared intellectual property to de-risk early-stage science and spin out venture-ready companies like Dispatch and Orbital Therapeutics. We also discuss the challenges of modernizing a historic non-profit with "no product" to sell , the intersection of AI and biomarkers with companies like ArteraAI , and PICI's massive data project, "Radiohead".

Karen is candid about her leadership philosophy: she is not a "keep the trains running" executive, but a leader built for transformation.