Creatine Beyond Muscle: Cognitive Benefits, Supplement Basics, and Pragmatic Sports Nutrition with Dr. Jose Antonio Jason Wright interviews Dr. Jose Antonio about creatine’s mainstream status, dosing (3–5 g/day vs. 10–20 g/day), and emerging cognition data, noting higher doses may be needed to raise brain creatine and benefits appear mainly under stress such as sleep deprivation, with vegans/vegetarians responding more. Antonio argues for a pragmatic approach that values RCTs but also real-world evidence, and debunks myths about “better” creatine forms (monohydrate is best studied), puffiness, and liver/kidney harm. He recommends focusing on exercise first, then basics like post-workout protein, creatine, a multivitamin, and omega-3s, with performance aids (sodium bicarbonate, beta-alanine, nitrates, carbs) depending on sport. They discuss EAAs, fasting, GLP-1 weight loss and lean mass loss, and Antonio’s current research on energy drinks (mostly caffeine), beta-hydroxybutyrate, and a planned creatine/eye-tracking study relevant to sports. Antonio invites listeners to the ISSN conference in Fort Lauderdale (June 17–19). 00:00 Creatine Comes Full Circle 03:56 Creatine Mainstream and Brain Dosing 05:33 Science Pragmatism Over Purism 11:17 Mechanisms Sleep and Vegans 14:40 Creatine Myths and Forms 18:00 Safety Kidneys and Liver 20:02 Simple Supplement Stack Over 40 28:27 EAAs Protein and Fasting 31:43 GLP-1s and Lean Mass Concerns 33:25 GLP-1 Lean Mass Tradeoffs 34:28 Body Positivity Backlash 35:46 Staying On Drugs Long Term 37:06 Building Exercise Habits 42:21 Health Over Vanity 42:59 Sponsor Authentic Health 44:30 Supplements Compliance Reality 48:08 Energy Drinks And BHB 49:57 Creatine For Eye Tracking 54:38 Training For Longevity 58:01 Lateral Movement And Balance 01:00:12 Conference Invite And Wrap 01:01:21 Medical Disclaimer