Your gut is talking — and your brain is listening. Discover how diet, microbiota, and even fasting reshape your brain chemistry, mood, and cognition in this deep dive into the gut-brain connection.

Your gut is talking to your brain — and your brain is listening. In this episode of The Cognitive Performer, we explore the gut-brain axis — the communication highway connecting your digestive system and your mind. Discover how trillions of microorganisms influence your mood, focus, memory, and long-term brain health. We’ll look at how diet shapes your microbiome, why certain bacteria can act like microscopic pharmacists, and what dietary patterns best protect cognitive function. From the serotonin-shaping power of Roseburia intestinalis to the fasting-linked boost in microglial cleanup, this episode unpacks the real neuroscience behind “gut feelings.”

Key Takeaways

• Roughly 90 % of the vagus-nerve signals run from gut → brain, not the other way around.
• The gut microbiome produces neurotransmitters such as serotonin, dopamine, and GABA that directly influence mood and cognition.
• Stress diverts tryptophan from serotonin production toward inflammation — but beneficial bacteria can reverse that shift.
• Mediterranean, DASH, and MIND diets consistently support brain health by nourishing diverse gut bacteria.
• Alternate-day fasting reshapes gut microbes and improves microglial function, translating into measurable cognitive gains.
• Building cognitive reserve through learning, social connection, movement, and sleep can cut dementia risk nearly in half.

Links and Resources

1. Qu S et al. (2024). Gut microbiota modulates neurotransmitter and gut-brain signaling. Microbiological Research, 287.
2. Zhou M. F. et al. (2023). Microbiome and the kynurenine metabolic pathway in depression. Microbiome, 11.
3. Gong Y et al. (2025). Healthy dietary patterns and cognitive performance. J. Prev. Alzheimer’s Dis., 12.
4. Mela V et al. (2025). Microbiota fasting-related changes ameliorate cognitive decline in obesity. Gut.
5. Ward N A et al. (2023). PROMED-EX Randomised Controlled Trial. BMJ Open, 13.
6. Bekdash R A (2024). Epigenetics, Nutrition, and the Brain. Int. J. Mol. Sci., 25.
7. Margolis K G et al. (2021). Microbiota-gut-brain axis modulation of enteric and central nervous system function. Gastroenterology, 160.
8. Cryan J F et al. (2021). Diet, microbiota, and host behavior — narrative review. Adv. Nutrition.

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