Dean Brown graduated from Berklee College of Music in 1977. During that time in Boston he performed with his own groups as well as Tiger's Baku, replacing Mike Stern in that group before moving to New York around 1980 and joining Billy Cobham's band.
Since 1982 Brown has been recording and/or touring worldwide with his own projects as well as with artists Marcus Miller, David Sanborn, Eric Clapton, Billy Cobham, The Brecker Brothers, Roberta Flack, Bob James, Joe Zawinul, George Duke, Victor Bailey, Bill Evans, and Steve Smith's Vital Information.
As a solo artist, Brown has produced five solo CDs with his fifth solo CD "Rolajafufu" just being released in Spring 2016. His first titled "Here" (2001) on ESC Records, is his all-star debut CD featuring jazz greats Michael Brecker, Marcus Miller, David Sanborn, Billy Cobham, George Duke, Randy Brecker, Christian McBride, Don Alias, Bill Evans, Bernard Wright and many others. His second record "Groove Warrior" (2004) on ESC Records, features another all-star lineup with Lalah Hathaway, Marcus Miller, Bernard Wright, JuJu House, Poogie Bell, Schuyler Deale, Booker King, and Patches Stewart, just to name a few. His third "DBIII" (2009)  on the BHM label features an all-star power trio with musical greats Dennis Chambers and Will Lee. His fourth CD "Unfinished Business"(2012) featuring yet another all-star cast of musicians with Marvin "Smitty" Smith, Kirk Whalum, Dennis Chambers, Jimmy Earl, Gerry Etkins and Hadrien Feraud among others.
Brown's studio guitar work can be heard on over 100 albums, including four Grammy Award winners. Records such as the Brecker Brothers' Return of the Brecker Brothers and Out of the Loop, Marcus Miller's The Sun Don't Lie, Billy Cobham's Warning, and Joe Zawinul's Faces and Places are just a few out of the long list. His live performances include DVDs with Marcus Miller, Billy Cobham, Gil Evans, David Sanborn, Louie Bellson, Bob James, and Steve Smith's Vital Information. Brown's compositions and arrangements are featured on albums by Les McCann, Dennis Chambers, Ricky Peterson, Steve Smith's Vital Information, and Billy Cobham.
As an educator and clinician Dean conducts master classes at schools and venues at home and abroad and teaches several classes of his own curriculum at Musicians Institute in Hollywood, California since 2006. Dean has also released an instructional/live DVD with publishing giant Hal Leonard for Musicians Institute titled "Modern Techniques for the Electric Guitarist"(2008) and has had several featured instructional articles in Guitar Player Magazine (US), Guitar World (US), Gittare and Bass (G), Bass Player, Jazz Life (Jp), Big Box (I), Muzikus (Cz), Guitarist (Fr) and 20th Century Guitar magazines (US). Dean and Runfly Studios have developed and released a popular ear training iPhone/iPad app called 'Pickup Tunes' based on his teaching techniques.