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63:: The science behind fasting as women (& why it is different than men!)
Episode 78 • Bonus Episode • 23rd June 2025 • Wellness Big Sis: The Pod • Dr. Kelsy Vick
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Wellness girl chat with us as we chat about the science behind fasting as women! We pull from the research regarding why women handle fasting differently than men and why fasting may not do what you think it is doing. Listen in to this episode, especially if you want to learn how fasting impacts your body composition, fatigue, energy levels, muscle building, hormonal balance, and much more!

Thorne Website:: https://s.thorne.com/Zgk7Y

My Thorne Dispensary & Recs:: https://www.thorne.com/u/drkelsyvickdpt

Message me for 35% off your Thorne orders!

49:: Female-Specific Fueling, Training & Performance:: https://wellness-big-sis-the-pod.captivate.fm/episode/49-female-specific-fueling-training-performance-with-dr-katie-hirsch-fasting-creatine-the-menstrual-cycle-more 

50:: break it down for the baddies:: Dr. Katie Hirsch::

https://wellness-big-sis-the-pod.captivate.fm/episode/50-break-it-down-for-the-baddies-female-specific-nutrition-training-performance-with-dr-katie-hirsch/ 

51:: Mel Sulaver talks nutrition in our 20s and 30s

https://wellness-big-sis-the-pod.captivate.fm/episode/51-mel-sulaver-rd-sports-nutritionist-talks-nutrition-in-our-20s-30s-as-women-part-i/ 

52:: Break it down for the baddies:: Mel Sulaver

https://wellness-big-sis-the-pod.captivate.fm/episode/52-break-it-down-for-the-baddies-mel-sulaver-rd-chats-nutrition-in-our-20s-30s/ 

Cortisol Series::

Part I:: (get to know cortisol)

https://wellness-big-sis-the-pod.captivate.fm/episode/31-all-about-cortisol-lets-get-to-know-the-misunderstood-mean-girl-hormone 

Part II:: (tips & tricks to balance your cortisol)

https://wellness-big-sis-the-pod.captivate.fm/episode/32-tips-tricks-for-how-to-balance-your-cortisol 

Part III:: (from chaos to calm)

https://wellness-big-sis-the-pod.captivate.fm/episode/33-from-chaos-to-calm-3-ways-to-handle-high-stress-situations 

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00:00- 00:17 Intro  

00:18- 01:57 Introduction to Fasting for Women  

01:58- 06:34 The Science Behind Fasting and Hormonal Balance  

06:35- 09:48 Metabolic Differences Between Men and Women  

09:49- 11:08 Fasting and Cortisol Levels  

11:09- 12:21 Recent Research and Intuitive Fasting (Part 1)  

12:22- 13:13 Thorne Supplements  

13:14- 15:42 Recent Research and Intuitive Fasting (Part 2)  

15:43- 18:11 Practical Tips for Women Who Fast  

18:12- 20:30 Conclusion and Personal Reflections

Mentioned in this episode:

Thorne Website:: https://s.thorne.com/Zgk7Y My Thorne Dispensary & Recs:: https://www.thorne.com/u/drkelsyvickdpt Message me for 35% off your Thorne orders!:: https://www.instagram.com/direct/t/17842574915346652

Transcripts

Speaker:

Let's dive into the truth

and science about fasting and

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intermittent fasting for women.

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Welcome back to Wellness of the Pod.

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I'm your host, Dr.

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Kelsey Vic, a board certified orthopedic

doctor of physical therapy and a

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pelvic floor physical therapist.

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And I've been having this conversation

a lot lately with a lot of friends,

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men honestly, too, that are in our

age range where they're asking, why

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aren't you fasting for your workouts?

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I fast for my workouts.

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Why don't you, as a woman, there's

so much research behind fasting for

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your workouts in order to get the body

composition goals, the toning goals,

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the aesthetic goals that you want.

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Why aren't you doing that as a woman?

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And recent research has shown that women

handle fasting differently than men.

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And so I wanted to cover that

today and dive into the science.

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And why fasting might not necessarily

be the route that we as women wanna

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take based on our hormonal physiology

and just how our neurons and different

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signaling molecules within our system

respond to fasting and lower energy,

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availability, We've chatted about fasting

before as part of other episodes with

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exercise physiologists and dieticians,

so I will link those episodes below

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if you wanna dive in more with someone

who is actually doing the research

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on this and the research that I will

be pulling from for this episode.

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But we chatted with two

experts on the topic,

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Two very prominent figures in this space.

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Dr.

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Katie Hirsch, and then also Mel Silver.

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So I will link those episodes below in

addition to the breakdown for the baddies

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episodes where we dive in a little bit

deeper, a little bit of a book club

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episode where we chat about fasting

and all of the topics that we covered

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in those episodes with those experts.

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So a little background on fasting.

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Fasting has historically been recommended

across the board, and I've heard of

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it, recommended for anything from

like cell cleansing and detoxing

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each of your cells to helping with

body composition goals and aesthetic.

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And exercise.

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There was a big push in the bodybuilding

world for fasted cardio workouts and

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fast cardio workouts for men and women.

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Based on, a little bit older research

that has only been done on men.

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So today we will dive into fasting for

women specifically, and some of the

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differences in how our bodies handle

those lower energy reserves when we

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are in a fasted state compared to

how men handle the same exact state.

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So if your goals revolve around

body composition, toning, aesthetic,

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cycle regularity, fertility, hormonal

regulation, cortisol regulation,

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and cortisol balancing, then this is

definitely an episode that I think

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you'll be interested in because

fasting covers all of those different

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topics within our body and it really

affects each of those systems.

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In our bodies as women.

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So let's start with how fasting affects

our hormonal balance, our fertility and

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our cycle regularity or irregularity.

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In general, our body has a plethora

of feedback loops where our body is

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in this cycle until something cues it

to stop or produce more of something.

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And our hormonal regulation

and nutrition is no different.

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So we have what we call the hypothalamic

pituitary gonadal axis, which is basically

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a fancy term for the hormonal reproductive

feedback loop within our bodies.

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We have the hypothalamus, which

is the, top of the system when

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it comes to hormonal release.

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So the hypothalamus has.

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Signaling hormones that they release

in order to signal more hormones

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to be released from the pituitary

gland that signal more hormones to be

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released from the reproductive organs.

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So the hypothalamic pituitary gonadal

axis is just a fancy name for hormones

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the signaling involved to release

the reproductive hormones that help

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with our fertility and our cycles.

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I think of it as like an intense game

of telephone, or I picture a chocolate

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fountain or a champagne fountain

where there's just a cascading effect

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where signaling molecules signal

other molecules that signal different

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hormones that help to regulate our

cycles or irregulate our cycles.

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So we have nutrient sensitive neurons

in our hypothalamus called kisspeptin

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neurons, and women have more of

these kisspeptin neurons, and they

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are also more sensitive than men.

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So when we are in a fasted state.

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Our bodies, our KIS neurons, sense that

we are in this lower energy availability

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state, and they will cue the response

on a larger scale and quicker than

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might be queued in a male system.

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So these kisspeptin neurons respond

to nutrient availability, and they

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are the gatekeeper for how our

hormonal response and our cycles

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and our fertility is regulated.

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They control a lot of other things too,

but speaking specifically in regards

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to hormonal balance and hormonal

imbalance, right now these kisspeptin

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neurons are like the gatekeeper.

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So they control the release of

gonadotropin releasing hormone, which

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goads, again, reproductive organs,

gonadotropin releasing hormone.

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This is a hormone released

from the hypothalamus.

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That again, is that telephone game

that signals another release from the

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pituitary gland, luteinizing hormone,

and follicle stimulating hormone.

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So this gonadotropin releasing hormone

is released from the hypothalamus and

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helps to signal the hormonal release

from the pituitary gland of luteinizing

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hormone and follicle stimulating hormone.

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And if you've listened to our cycle

episodes, you know that there's

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a sort of rollercoaster ride that

happens between these two hormones

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during our menstrual cycle.

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So fasting causes a decline in these

kisspeptin neurons, which affects

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gonadotropin releasing hormone release,

and then affects the regularity

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of our cycle because luteinizing

hormone and follicle stimulating

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hormone will be affected as well.

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So this cascading effect, this

telephone game, all starts

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with our bodies sensing a fasted

state, which cues those kisspeptin

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neurons, which cues less release of

gonadotropin releasing hormone in that

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hypothalamus at top of the pathway,

which then affects luteinizing hormone

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and follicle stimulating hormone

release from that pituitary gland.

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Again, that middle guy for that hormonal

cascade, which in turn affects our cycles.

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So let's switch to

metabolism a little bit.

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And this is where women actually thrive

because we are metabolically superior,

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or metabolically more efficient

or more flexible in how we utilize

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certain fuel sources within our body.

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We are able to switch between

different fuel sources and take

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from different fuel sources more

efficiently than a man system is.

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So historically, I guess what we

utilize for our fuel sources has

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typically followed this pathway.

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We first utilize blood glucose,

then we utilize stored glycogen

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within our liver and our muscles,

which is the stored form of glucose.

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So glycogen, glucose, you can

think of them as the same thing.

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Glycogen to just takes a little bit to

get to the point where we can use it

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as energy, as glucose, and it is the

stored form of glucose in the liver.

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And the muscles.

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So we first tap into the blood

glucose levels, 'cause that's

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usually the most available and

the most readily available for us.

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Then we tap into liver and

muscle glycogen stores, and then

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we tap into free fatty acids.

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That's historically what we've believed

as how a body taps into different fuel

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sources for energy, whether that's for

exercise or just like day-to-day tasks.

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However, it's been shown that women

specifically have this flexibility within

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their metabolic system where we tap

into that blood glucose first, but then

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we actually transition to those free

fatty acids a lot quicker than a manez.

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They have to go through that process

where we can go straight from blood

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glucose, utilizing blood glucose

as our fuel to free fatty acids.

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This is because we have a lot

more oxidative fibers within

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our skeletal muscle tissues.

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And so that is one of the theories

that has been brought up to why

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we tap into those free fatty

acids quicker than Amand does.

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So one of the goals with fasting could

be, Hey, let's decrease our glucose

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stores initially so that we tap into

those free fatty acid quicker, or, that's

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historically been one of the theories.

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And for a man that might actually make

sense because if we can limit the amount

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of glucose that they have to utilize at

the beginning of that pathway, they might

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tap into those free fatty acid storage

is early on in their workout, where for

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women, we don't actually have to do that.

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We kind of skip that step.

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We skip the benefit of fasting

because, we utilize that glucose

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within the bloodstream first before

we tap into those free fatty acids.

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And a lot of people think, oh, let's tap

into those free fatty acids as fuel as

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soon as we can so that we're burning fat.

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But this is not necessarily

like a one-to-one ratio.

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Yes, it does help that we can tap

into those free fatty acids, but

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it's a lot more complex than that.

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But that is one of the reasons fasting

has been promoted is because if we can.

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Decrease the circulating glucose

levels or stored glucose levels,

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then we might be able to tap into

those free fatty acids sooner.

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Whereas women, we have that flexibility to

go, okay, utilize all that blood glucose

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first that circulating quick energy first

before we tap into those free fatty acids.

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But we don't necessarily have

to go through the entire process

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that we've historically thought.

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That men go through, but maybe a

woman does not necessarily go through

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So let's chat fasting and

how it affects our cortisol.

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And cortisol is always presented as the

bad guy and we've done episodes on it,

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calling it the misunderstood mean girls.

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So I will link all of those episodes

below 'cause I do not want you

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to think cortisol is the bad guy.

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We need cortisol, but fasting

for prolonged periods of time

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can elevate our cortisol levels.

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Fasting for almost greater than 12 hours.

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It's been shown to elevate

our cortisol levels.

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And if you think.

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Your sleep window also counts as fasting.

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We're not expected to wake up

and eat a snack during sleep,

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so that counts as fasting.

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So greater than 12 hours is actually,

it sounds like a lot, but it's

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actually not that long of a time.

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So fasting for greater than 12

hours can increase some of our

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cortisol levels within our body.

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So higher cortisol for a prolonged

period of time can lead to muscle

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loss, fatigue, and thyroid dysfunction.

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So all of those things we definitely do

not want, especially if our goals are

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energy levels, fertility, regularity,

hormonal balance, muscle building, body

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composition changes, all of the things.

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But again, it's not that cortisol's

bad, it's just that high levels

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for a prolonged period of time

is not necessarily what we want.

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We wanna maintain that cortisol balance

and that cortisol rollercoaster that

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we have throughout the day with those

natural elevations that happen in

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the morning, and then the natural

declines that happen later in the day.

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So this is all relatively recent research

in the grand scheme of things where we are

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just now starting to study the female in

comparison to the male, where we actually

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separate our study groups, male and female

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there's so many things that are different

about our bodies, how we store fat, how

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our muscle fibers are structured when we.

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Tap into different fuel

sources within our bodies.

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So we've started biasing out

different groups to know how does a

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woman's body actually handle this?

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So more research is definitely needed.

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More research on humans

is definitely needed.

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We've done a lot of animal studies,

but more is definitely needed on

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humans and I think future research is.

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Going to need to be dedicated towards

people with special conditions.

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'cause there is a study that has been

published on PCOS, I believe it was 2023

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or 2024, so again, relatively recent where

women with PCOS have found benefits with

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fasting when it comes to muscle building,

and then also decreasing visceral fat

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and subcutaneous fat within their system.

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So I think there needs to be

condition specific research under

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the umbrella of female research.

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So this is just something that my mind

has been gravitating towards recently

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and this is something that we have

just chatted about recently with a lot

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of family and friends, and I wanted

to cover this from this research and

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science back perspective so that you

guys are aware of the newer research

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on fasting for females specifically.

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But with all of that being said, I had

a great conversation with a friend of

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mine who is reading more on fasting and

she was talking about the intuitiveness

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of fasting and the need to be intuitive

with your own body despite the research.

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And I really loved this because yes,

there is research on female physiology

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and how our bodies tap into different

fuel sources, how we raise certain

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hormones within our system, how our body.

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It taps into different resources that

we might not wanna tap into for fuel,

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like muscle tissue earlier than a man.

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So there's all of these reasons

why someone might choose to fast

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or not fast, But fasting can

mean a lot of different things.

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It can mean complete fast.

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It can mean liquids only.

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It can mean intermittent fasting

or time restricted eating.

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It can mean eating less, but more

frequently throughout the day.

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There's so many descriptions

of fasting and they're not all.

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The same across research.

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Is it time restricted fasting,

where we're fasting for 12 hours?

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Is it littler meals throughout the day?

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Is it liquid only?

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Is it a complete 24 hour

fast or a multi-day fast?

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So there's lots of different ways

to fast, and I'm not saying that.

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No female can benefit from fasting.

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So I think there needs to be some

intuitiveness about listening to your

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own body when it comes to fasting.

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So if you found that your body

actually does benefit from fasting,

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or it feels better with fasting

for some reason or another.

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I'm not doubting you on that.

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I'm not saying that is wrong at

all, or that you are wrong for

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listening to your body in that way.

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I think there are some people who do

benefit from fasting in whatever form

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that might be, and so if you are . One

of those people that might benefit

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from fasting or think that your body

or your sleep or your fatigue or

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energy levels benefits from fasting?

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There are a few things to keep in mind, I

guess to offset maybe the negative impacts

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that fasting has on a woman's body.

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We don't want those raised cortisol

levels for a prolonged period of time.

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We don't want cycle irregularity.

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We don't want muscle loss.

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We don't want so many

things that fasting and.

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Having lower energy availability might

lead us to, and so there's a few things.

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If your body does seem to enjoy

fasting in some sort of form, there

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are some things that are recommended

in order to help your body, combat

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some of those negative effects.

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So if you do benefit from fasting in some

way, make sure you are getting adequate

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protein intake during that feeding window.

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Protein specifically all macronutrients,

of course, but protein specifically

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is one where if you are not

getting it during your feeding

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window, your body is not able to.

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Build muscle.

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It's not able to help some of these

processes that go on within the body.

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Same thing with carbohydrates,

same thing with fat.

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So making sure you're getting

adequate macronutrients and

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micronutrients during that feeding

window is super duper important.

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Fasted exercise specifically

also messes with our appetite

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control center, let's call it.

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So if you can plan your

exercise when you are in a non.

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Fasted state, so when you're in

your feeding window, That is only

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going to help your body adapt to

that exercise stimulus better.

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If you don't respond well to eating

before exercise, even giving your body

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a little bit of a cue that you are not

in a low energy availability state, by

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feeding it with a little bit of glucose,

a little bit of protein, giving it some

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signal to say, Hey body, we are okay.

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We don't need to break down

necessities within our body

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in order to fuel this workout.

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So almost eating, even if it's like

a quarter of a banana or a little bit

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of protein before your workout to help

your body sense that it is okay, we

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can use those for fuel for a little bit

and then we can tap into some of the

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other fuel sources that isn't things

that we want, like muscle tissue.

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And then try keeping your fasted

window between 12 and 14 hours.

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Again, anything over 12 has been

shown to raise those cortisol levels.

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So if we can keep it between that

12 to 14 hours, that's a little

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bit safer of a fasting window.

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Try to eat within 30 minutes of waking

as well, and then stopping eating around

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that six to 7:00 PM timeframe too.

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Keeping that fasted window safe

rather than pushing it to those 20

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hour fasts or those 16 hour fasts.

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So I hope it was helpful to go over some

of the science regarding fasting for

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women compared to men, and then also

if your body does sense that fasting

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is good for it, understanding what you

can do to combat some of the negative

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effects that might come from fasting.

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So I hope you guys enjoyed this episode.

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I hope you guys are having the most

wonderful start to your summer.

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I know I am.

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I've been enjoying this little bit of a.

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I guess slow down with the podcast

where I'm only releasing one a week.

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And it's so funny that if you guys

remembered a few episodes back, I said

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I was gonna drop to one episode a week

during the summer because I was just

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sensing that God had put it on my heart

to, not push so hard to release two

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00:17:15,577 --> 00:17:18,487

episodes a week, even though I really

do enjoy it, and I really do feel

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00:17:18,487 --> 00:17:20,077

like it's good for the podcast growth.

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00:17:20,287 --> 00:17:24,817

For some reason, it was just on my heart

that, hey, maybe this time you do one

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00:17:24,817 --> 00:17:27,696

a week during the summer and then pick

it back up to two a week in the fall.

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And I didn't know why that was on

my heart, but it's already been

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00:17:31,522 --> 00:17:36,327

revealed to me why that was the

case and I just feel like it was.

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A wonderful, I guess example of

actually listening and hearing those

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little whispers and then following

through with them and obeying them.

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And so I've already been reaping some

of the blessings from going back to,

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one time a week and understanding why

I might've been receiving that whisper

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and the future of the summer for me.

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So I will maybe share a little bit more.

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Once everything's finalized, but literally

the week after I decided and released that

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00:18:02,739 --> 00:18:07,469

episode saying, Hey, I've been feeling

called to release only one episode a week.

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00:18:07,469 --> 00:18:09,869

I'm not sure why, but I feel like

there's a bigger plan for this.

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Almost a week after I immediately knew

exactly what he was calling me to do.

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So I am very grateful.

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I just wanted to share that with you guys

as a little bit of a message of, hope and.

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Trust and patience and

listening to those whispers.

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So this episode took a turn, but

I hope you guys enjoyed the rest

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of this episode, the fasting part.

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I hope you learned a lot.

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If you've also been having this

conversation with girls in your

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life or even men in your life,

please share this episode.

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It.

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00:18:37,899 --> 00:18:42,099

Super Duper helps the podcast to grow,

and I just appreciate it so very much.

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So thank you guys for listening.

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I hope you enjoyed this episode.

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I'll leave all of the links below to all

the episodes that I referenced in this

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podcast and I'll see you guys again on the

next episode of Wellness Books is the pod.

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