Twentysomething Anna (Alexandra McVicker) leaves her small, transphobic hometown to start a new life in the city with her sister when she quickly finds herself face-to-face with Gen (Avalon Fast), a confident young woman she’d first seen in visions. Gen, Anna learns, has supernatural powers—powers that the two of them share. Their bond of magic and romance is threatened when Gen inadvertently unleashes a demon in Danny (Jordan Dulieu), Anna’s one-time fling and neighbor, and the mysterious evil begins targeting—and feeding on—everyone close to them.

About the filmmaker - After writing and directing a string of low-budget horror shorts in her teens, Maio Mackay—who begins every feature with the on-screen evocation of “A Transgender Film”—erupted onto the scene with her 2021 vampire horror-comedy So Vam, starring BenDeLaCreme and Etcetera Etcetera from Drag Race, which was released as a Shudder Original when she was only sixteen years old. Following her breakout, she helmed Bad Girl Boogey (2022), the explosive underground horror T Blockers (2023), which earned her the Emerging Talent Award from Outfest L.A.; musical horror-comedy Satranic Panic (2023); and queer holiday horror Carnage for Christmas (2024), with I Saw the TV Glow’s Jane Schoenbrun executive producing her forthcoming feature Our Effed Up World. The Serpent’s Skin is the 21-years-old trans Australian filmmaker's most ambitious film to date, combining her distinct filmmaking voice—known for channeling genre tropes through a trans lens, her innovative approach to aesthetics, and a unique wit—with a larger scope that leans into a darker storyline and a loving influence of 90s cult television like Buffy the Vampire Slayer and Charmed.