For decades, I started every New Year the same way.
In January, I promised myself this would be the year.
By February, I tried harder.
Every spring, I adjusted the plan.
And by summer or fall, the weight crept back.
That cycle repeated not because I lacked knowledge, discipline, or effort. Instead, it repeated because I misunderstood biology — at least when it came to myself.
This year is different.
For the first time since Ronald Reagan was first elected, weight loss is not at the top of my New Year’s resolution list. Not because I stopped caring, but because I lost 45 pounds with the help of Zepbound over the last year. More importantly, however, I learned something that reshaped how I think about obesity, healthspan, and shame.
Before anything else, let me be clear: this is not medical advice. This is a story. Anecdotes are not evidence, even when the anecdote is from a physician. Nevertheless, stories help us understand science when data alone fails to move us.
And this story matters.
For years, people told me — and millions of others — the same thing: move more and eat less. At first glance, that advice sounds logical. After all, calories matter. Energy balance matters.
However, reality is more complicated.
To begin with, I am a surgeon. Surgical training requires extraordinary willpower. Moreover, I’ve logged food meticulously, cooked Mediterranean-style meals, exercised consistently, and followed every evidence-based recommendation I’ve ever given patients.
Meanwhile, Oprah has willpower. Olympic athletes have willpower. Yet obesity persists.
Sure, willpower works briefly. In fact, go on a liquid protein diet, and the weight will fall off quickly. Unfortunately, the food noise remains. Eventually, biology wins. Always.
In the same way you cannot positive-think your way out of hypertension, cholesterol, diabetes, cancer, or heart disease, you cannot willpower your way out of obesity. Obesity is a disease. It is not a moral failure.
Ironically, I knew this intellectually. Nevertheless, I failed to apply it to myself. We have a name for that: cognitive dissonance.
The real turning point did not come from reading another study. Instead, it came from listening to people I trusted.
One colleague quietly lost weight on a GLP-1. Another friend told me something more striking: the food noise stopped. Alcohol lost its appeal. Smoking no longer called.
That phrase — food noise — suddenly explained decades of struggle.
To illustrate, think of sleeping near Lake Shore Drive in Chicago. At first, traffic noise dominates your awareness. Eventually, it fades into the background. Only when you leave the city do you realize how loud it was.
Food noise works the same way.
When GLP-1 therapy quieted that background signal, eating slowed naturally. Meals ended without effort. Desire changed without rules. Biology shifted.
Notably, calories did not lower my stress. Calories did not improve my sleep. Calories did not stop snoring. Biology did.
Interestingly, weight loss was not the first change I noticed.
Sleep improved almost immediately. Stress dropped dramatically. Commutes that once registered hours of physiologic stress now barely registered minutes. Appetite normalized. Eating slowed.
These changes matter because sleep and stress directly affect inflammation, metabolic health, appetite signaling, and long-term disease risk. In other words, healthspan improved before the scale reflected anything meaningful.
That observation alone reframed the entire experience.
Along the way, something else happened.
Friends noticed.
Predictably, they asked the same question everyone asks: What diet is working? After I answered honestly, several started their own journeys.
Soon enough, we formed an informal support group. People texted. Others called. Questions surfaced: Is this normal? Should I eat this? Does this feeling pass?
Support did not mean coaching. Rather, support meant context. Shared experience reduced anxiety. Honest conversations prevented unnecessary panic.
Not surprisingly, patterns emerged. People still loved great food. Wine interest decreased naturally. Travel did not end. Joy remained intact.
Support mattered because isolation amplifies shame.
Equally important, practical realities surfaced.
Eating less means needing micronutrients, not fewer of them. Unfortunately, some vitamins fail when appetite drops. In fact, the only time I vomited was after taking a vitamin on an empty stomach. That lesson mirrored decades of bariatric follow-up experience.
For me, AG1 worked. No sponsorship exists here. Nevertheless, cost raises questions. With a background in culinary medicine, developing a better formulation makes sense. Thiamine deficiency, for example, causes devastating neurologic consequences. This is not theoretical.
Similarly, bowel habits change. Less intake means less output. Fewer bowel movements do not equal constipation. Fiber still matters. Mediterranean-style eating naturally solves most of this problem.
Understanding physiology prevents fear.
At some point, frustration turned into obligation.
Recently, a physician who has never used a GLP-1 published a book about eating on GLP-1 therapy. That bothered me more than it should have.
Given my background — weight-loss surgery, culinary medicine, and lived experience — I realized I had to write this book. Not to sell diets, but to explain reality.
The working title?
Willpower Is B.S.
Subtlety has never been my strength.
This book will focus on biology, food ideas, micronutrients, behavior, and healthspan. Above all, it will remove shame from the conversation.
Incidentally, my literary agent retired long ago. Therefore, if you know someone who understands medicine, food, and honesty, I’m back in the market.
At the same time, conversations kept expanding beyond weight loss.
Healthspan matters more than thinness. Longevity depends on sleep, stress, nutrition, social connection, and movement. Accordingly, the Mediterranean Healthspan Cruise was born.
This is not a weight-loss cruise. Instead, it’s a learning experience. We will discuss food, medicine, science, and aging. Yes, there will be a GLP-1 support session. Equally, there will be conversations for everyone.
Learning works best in a community.
As I write this, I’m preparing to inject my 7.5 mg dose of Zepbound. I still hate needles. Some things never change.
Nevertheless, this is only part one of the journey.
Science progresses when we admit what we got wrong.
This time, I listened.
>> Dr. Terry Simpson: M Today is my coming out party. Today I'm coming
Speaker:out. About me. Because this is the first new year
Speaker:of my adult life where weight loss is not at the
Speaker:top of my resolution list. And that's not because
Speaker:I gave up. It's because over the last year, I have
Speaker:lost 45 pounds with the help of Zephound, a GLP1
Speaker:agonist. And today on 4Q, I'm finally ready to
Speaker:tell you that story. Not as a success story, not
Speaker:as advice, and certainly not as a moral lesson,
Speaker:but as an honest account of what actually
Speaker:happened. Why this wasn't willpower, why it wasn't
Speaker:just eating better, and why this changed far more
Speaker:than my weight. Some of you know I'm a weight loss
Speaker:surgeon. Some of you know I'm trained in culinary
Speaker:medicine. And some of you know I've spent my
Speaker:career helping other people lose weight. What you
Speaker:may not know is how much shame I carried doing all
Speaker:that. So today I'm telling you my story. The
Speaker:guilt, the biology, the food noise, and what this
Speaker:last year has meant to me. Because if this story
Speaker:resonates with you or someone you love, that
Speaker:matters. This is the story of how science saved my
Speaker:life. This is also the first new year where I
Speaker:don't have weight loss as a resolution. In fact,
Speaker:I've had weight loss as my New Year's resolution
Speaker:since Ronald Reagan was first elected. Every year,
Speaker:same promise, same guilt. And I don't think I ever
Speaker:promised that more strongly than in 2010 when my
Speaker:son JJ was born. I'm, um, one of those older
Speaker:parents. I know it's hard to believe, but if there
Speaker:was ever motivation, that was it. I was going to
Speaker:lose weight. I was going to get healthier because
Speaker:I had this little child that I wanted to spend a
Speaker:lot of the rest of my life knowing. Some years the
Speaker:promise was stronger. Some years it was better.
Speaker:Every year until this last year, I might lose a
Speaker:few, then gain it back. I know how to eat. I know
Speaker:how to cook. Do you know that I almost set the
Speaker:record for logging my daily food on Noom or over
Speaker:2000 days? This was never about knowledge. This
Speaker:was never about effort. I am your Chief Medical
Speaker:Explanationist, Dr. Terri Simpson, and this is
Speaker:Fork U Fork University, where we make sense of the
Speaker:madness of weight loss, bust myths, and talk
Speaker:honestly about food and medicine.
Speaker:Let's talk talk about willpower. And let me start
Speaker:with a confession. I've known the truth about
Speaker:willpower for years. I just didn't believe it for
Speaker:myself. I have willpower. I'm a surgeon, you don't
Speaker:get through surgical training without willpower.
Speaker:And you don't stand in an operating room for hours
Speaker:making decisions that matter without willpower.
Speaker:And let's be honest. Oprah has willpower. She has
Speaker:discipline. She has access. She has resources. And
Speaker:yet all the willpower in the world didn't allow me
Speaker:or Oprah to lose weight and keep it off. Sure,
Speaker:with enough willpower, you can lose weight for a
Speaker:while. God knows I've done it. Liquid protein
Speaker:diets, rigid eating, white knuckling my way
Speaker:through, you'll lose the weight. I've done it more
Speaker:than once. But you still hear the food noise.
Speaker:Willpower doesn't quiet food noise. It doesn't
Speaker:shut off the background pull toward food just
Speaker:tells you to fight it all day, every day. And
Speaker:eventually, food noise wins. Because biology beats
Speaker:psychology every single time. You can't willpower
Speaker:your way out of obesity any more than you can
Speaker:positive think your way out of high blood pressure
Speaker:or high cholesterol or diabetes or heart disease
Speaker:or cancer. We don't tell people with hypertension
Speaker:to believe harder yet with obesity, we pretend
Speaker:willpower is the treatment. It isn't. And here's
Speaker:where my shame lived. As a weight loss surgeon, I
Speaker:told my patients this. I corrected people when
Speaker:they said surgery was the easy way out. Because
Speaker:surgery does not make the stomach smaller. It
Speaker:changes gut hormones. It changes brain signaling.
Speaker:It changes appetite regulation. It changes
Speaker:biology. I believed that data fully for everyone
Speaker:else, but not for me. I held myself to a different
Speaker:standard. I gave everyone else grace, but I didn't
Speaker:give it to myself. I didn't gain more willpower
Speaker:from a needle. I'm not a better person because I
Speaker:lost weight. I'm not morally superior because I
Speaker:moved from obese to a normal weight. I didn't
Speaker:become more disciplined. The biology changed.
Speaker:That's it. I know this intellectually. I taught
Speaker:it, I lived it through my patients, but I didn't
Speaker:apply it to myself. You know, we have a name for
Speaker:that, cognitive dissonance. Now, when I look back,
Speaker:the turning point came down to two people and one
Speaker:event before that. Let me say this clearly. This
Speaker:wasn't ignorance. I'd known about GLP1 medications
Speaker:for years. I'd read the trials. I understood the
Speaker:mechanism. I prescribed them to my patients, and
Speaker:my patients did well. But knowing the science and
Speaker:believing it applies to you are two different
Speaker:things. About seven years ago, a very good friend
Speaker:of mine, an internist, was one of the
Speaker:investigators setting GLP1 medications for weight
Speaker:loss. She was stunned by the results and told me
Speaker:that these medications are going to replace weight
Speaker:loss surgery. Sure, I said. I wasn't impressed.
Speaker:I'd seen other weight loss medications before, but
Speaker:the data wasn't weak. Anyway, let's start with my
Speaker:journey. It was a nurse that I worked with.
Speaker:Nothing dramatic, nothing preachy. She just kept
Speaker:losing weight quietly. And she mentioned her
Speaker:experience on ozempic and would occasionally ask
Speaker:me as a weight loss surgeon about ozempic. No
Speaker:evangelism, um, no sales pitch. She felt better.
Speaker:She did easier. The food noise was gone. Now, as a
Speaker:surgeon, you learn to respect quiet results
Speaker:because they are typically real. The second was a
Speaker:person. Someone I work with in Alaska. In fact,
Speaker:she and I grew up in the same town, Ketchikan.
Speaker:Then she told me something that stopped me cold.
Speaker:Yep, she had lost weight, but that wasn't the
Speaker:headline. She said the food noise stopped. And
Speaker:then she said something else. Her interest in
Speaker:alcohol dropped. And she had stopped smoking. This
Speaker:is when it stopped being about weight. That's when
Speaker:about the biology of it became real. Then came the
Speaker:event. Eli Lilly lowered the self pay price to
Speaker:about $500 a month. Suddenly, this wasn't
Speaker:theoretical. This was something I could budget. So
Speaker:I called my friend, Dr. Michael Albert. Now,
Speaker:Michael is a board certified obesity medicine
Speaker:specialist. And that matters. If you're
Speaker:considering this journey, Find someone who's
Speaker:actually trained in obesity medicine, not someone
Speaker:who says they are. Michael assumed I was calling
Speaker:about a patient. I said, no, no Michael. I'm
Speaker:calling about me. No judgment. Just one question.
Speaker:What's your height and weight? That was 45 pounds
Speaker:ago.
Speaker:Let me tell you about the first injection. The
Speaker:package derived from Eli Lilly. Inside were vials
Speaker:of zepbound syringes, needles, alcohol, swabs. I
Speaker:have a confession to make. Even though I got the
Speaker:polio vaccine, even though I keep up with my
Speaker:boosters, I hate needles. I. I hate them. I don't
Speaker:like them. I don't like getting injections. I will
Speaker:put off for any reason getting a booster, even
Speaker:though I do it. So I did the appropriate thing. I
Speaker:hydrated with Pedialyte in case there was some
Speaker:nausea. And, um, finding subcutaneous fat for my
Speaker:first injection. It just wasn't a problem. I mean,
Speaker:a man with belly has options. So I put alcohol on
Speaker:the vial. I put the air from the syringe into the
Speaker:vial. I swiped my skin with alcohol, thinking, am
Speaker:I really doing this? And I did it. I put the
Speaker:needle in. I put the plunger down. In half A CC
Speaker:was 2.5 milligrams of Zepbound subcutaneous. That
Speaker:was it. I wondered if I needed a sucker. The next
Speaker:morning, my partner said, that is the first time
Speaker:you haven't snored in years. I checked my withing
Speaker:sleep score. It was the best it had ever been. I
Speaker:had hardly ever cracked 70 as a sleep score, and
Speaker:all of a sudden, I was hitting the 80s. Let me
Speaker:tell you about another change. Before I injected
Speaker:myself, I did something very telling. I bought a
Speaker:new blender. Because when you know you're going to
Speaker:change your life or make a new habit, you prepare.
Speaker:It's like when I decided to take up running again.
Speaker:Before the first run, I, of course, bought new
Speaker:shoes and a tracksuit. Matching, of course. Same
Speaker:instinct. So I knew this change might mean more
Speaker:smoothies. Not just as a diet trick, but as a
Speaker:practical way to get nutrition in, you know, the
Speaker:fruits, the ber, that good stuff. And my Vitamix
Speaker:had been with me for 15 years. But it's a beast,
Speaker:and I wanted something easier. After all, I was
Speaker:going to inject myself. I deserved a simple
Speaker:blender. And so I did the research. I saw
Speaker:Wirecutter from the New York Times. I read
Speaker:reviews. I looked at comparisons. I saw lots of
Speaker:videos on TikTok, my favorite medium. And I bought
Speaker:a Nutribullet. Amazon delivered it the day before
Speaker:I started Zepboun. So I unpacked it, didn't read
Speaker:the instructions, of course, and had all the parts
Speaker:washed and ready to go. The next morning, after my
Speaker:first injection, I wondered about my breakfast.
Speaker:And I was traveling that day. So I made my usual
Speaker:smoothie, which is kind of for me. Oat milk, a
Speaker:banana, frozen blueberries, some egg protein. I'm
Speaker:lactose intolerant, some peanut butter. And by the
Speaker:way, if you want the recipe, it's on
Speaker:terrysimpson.com now. You need to understand
Speaker:something about me. If you've not known me. I am
Speaker:known for eating fast. People notice it. I'm
Speaker:usually the first one diet, always. And so that
Speaker:morning, when I was traveling along in my commute,
Speaker:which is about two hours at the time, that
Speaker:smoothie wasn't guzzled. I would sip a little bit
Speaker:and put it down normally with my smoothie. If I'm
Speaker:traveling, that smoothie is gone, like a man who
Speaker:found an oasis in the middle of desert. But this I
Speaker:sipped, not consciously. It just happened. And
Speaker:then that night, I made some salmon with broccoli
Speaker:and chickpeas, one of my favorite recipes, and I
Speaker:love salmon. And I ate it slowly and then I
Speaker:stopped. I ate half the plate. Not because I was
Speaker:uncomfortable, that was just done. Something had
Speaker:stopped. Something went quiet and reminded me.
Speaker:That's food noise. Do you know what it reminded me
Speaker:of? Years ago, when I was at the University of
Speaker:Chicago, I slept with the city noise. I lived by
Speaker:Lakeshore Drive, There were trains in the
Speaker:background, there was lots of cars going by 24
Speaker:hours a day. And I would sleep to that. You never
Speaker:noticed that background noise until I would go
Speaker:home to catch canalaska at my parents house. And I
Speaker:would take time to fall asleep because there
Speaker:wasn't that background city noise. It was gone.
Speaker:And that's what happened in my brain. Food noise
Speaker:was gone. I didn't even know it was there. That's
Speaker:what food noise was.
Speaker:So things that changed first, before the scale
Speaker:moved, that first night sleep, the second thing I
Speaker:noticed was stress. Now sleep resets hormones,
Speaker:lowers inflammation, recalibrates metabolism.
Speaker:We've known this for years. And less sleep
Speaker:actually increases appetite. Stress does. Does
Speaker:too. So before this, you know, I commute a lot. I
Speaker:live in the north LA central coast area and
Speaker:commuting is just sort of a fact of life here. But
Speaker:hours of commute meant a lot of physiologic
Speaker:stress. And so when I would look at my Withings or
Speaker:my whoop watch and you would see the amount of
Speaker:stress I would have, if I had commuted two hours a
Speaker:day, I'd have two hours of stress. Now I notice
Speaker:the first week I might have five minutes of
Speaker:stress. Calories didn't lower the stress, calories
Speaker:didn't improve the sleep, the biology did. And
Speaker:over time, friends started to notice. People
Speaker:noticed. Now I have a few friends that were a
Speaker:little more corpulent and they would always ask
Speaker:when they would see me, hey, what diet are you on?
Speaker:What are you doing, Terry? So finally I told them
Speaker:different ones at different times. And one by one,
Speaker:all of them began their own journey on zeppbound.
Speaker:And without planning it, we formed our own little
Speaker:support group. They would call me or text me when
Speaker:they had an issue like, is this normal? What would
Speaker:you do? Does this go away? And we would talk it
Speaker:through, not as coaching, not as a program, just
Speaker:people who understand. Let me tell you about one
Speaker:of my friends. She travels constantly. If you were
Speaker:to see her Instagram, if you follow her, it's full
Speaker:of wonderful foods from wonderful restaurants
Speaker:around the something like 50 plus countries she's
Speaker:visited. I have traveled with her around the world
Speaker:and we both love great food and oddly, we still
Speaker:do. She still Loves great food. I still love great
Speaker:food. When we go out to eat together, we get great
Speaker:food. Interestingly, our desire for wine has kind
Speaker:of completely gone, but we still enjoy great food.
Speaker:Just small plates. Enjoy the taste, not the
Speaker:volume. I have another buddy, he travels
Speaker:constantly for work. Great guy. He has this
Speaker:amazing workout regimen he does in every hotel
Speaker:room, involving 100 push ups and calisthenics and
Speaker:all of this stuff. And he was in shape, it was
Speaker:just a round shape. So he asked me, what are you
Speaker:doing, Terry? And I said, I'm doing Zepbound. I
Speaker:gave him the number of my guy, Dr. Albert. He
Speaker:called him up, he started it. You know, New Year's
Speaker:is coming. And he said, he started laughing. He
Speaker:said I had to buy a new tuxedo. Look at this. He
Speaker:looks great. Then there's another friend of mine.
Speaker:He's a fellow physician. I've known him for 25
Speaker:years. We have gone and lectured together in
Speaker:countries from New Zealand to Sweden and always go
Speaker:out together at great restaurants. I've seen him
Speaker:go up and down in weight over time. Oh, I'm on the
Speaker:Paleo diet. I'm losing weight and then regaining
Speaker:the weight. Now he's on Zepbound. And like me,
Speaker:he'll say, what do you think? Should I increase in
Speaker:dose? Anyway, I've always believed in support
Speaker:groups, but now I understand them from the inside.
Speaker:I'm not your coach, and I don't do this alone. I
Speaker:work with a company called Accomplished Health.
Speaker:No, they don't pay me, they don't sponsor the
Speaker:podcast, but they practice real obesity medicine.
Speaker:And maybe if they hear this, they'll send me a
Speaker:coffee cup, which I would love. Here's a warning.
Speaker:If you eat less, you still need micronutrients.
Speaker:And that's not theoretical. Here's the thing, as a
Speaker:weight loss surgeon, I've always told my patients,
Speaker:you need to take a multivitamin. And I realized on
Speaker:a GLP1, I need to take a multivitamin also. And
Speaker:the first time I ever threw up, the only time I've
Speaker:thrown up on this, was when I took a vitamin on an
Speaker:empty stomach. Sip of coffee and boom, it wasn't
Speaker:staying down. Now, I'd heard this for years from
Speaker:weight loss surgery patients that some vitamins
Speaker:just don't work. And I even tried some of these
Speaker:fancy bariatric vitamins and they didn't work
Speaker:either. And the one vitamin group that worked for
Speaker:me was AG1. No, again, not a sponsorship. It's not
Speaker:an ad. They don't pay me. This stuff is way too
Speaker:expensive. Which made me think I should probably
Speaker:develop a vitamin routine for people on empty
Speaker:stomachs, because vitamins are critical,
Speaker:especially thiamine, and the deficiency in
Speaker:thiamine can be devastating. That's another reason
Speaker:you really need someone to help you with this
Speaker:journey.
Speaker:Now let's talk bowel movements. Here's something
Speaker:really simple. If you eat less, you're going to
Speaker:have fewer bowel movements and that does not mean
Speaker:constipation. Less in means less out. You don't
Speaker:need to go to the bathroom every day. Fiber still
Speaker:matters. Mediterranean diet helps naturally.
Speaker:Vitamins, legumes, whole groups. This is about
Speaker:understanding physiology and not panicking so why
Speaker:am I going to write a book? I remember I was
Speaker:disturbed when I saw a physician who's never been
Speaker:on GL Pillar 1, never been on a wait list, but is
Speaker:an obesity physician and fairly good and wrote a
Speaker:book about how to eat on one. And I realized with
Speaker:my background weight loss, surgery, culinary
Speaker:medicine and living is I have to write a book and
Speaker:I'm thinking of calling it Willpower Is bs. You
Speaker:know me. Subtle. Now my book agent retired long
Speaker:ago, so if any of you know or are a good literary
Speaker:agent, hey, hit me up. I'm back in the market.
Speaker:Anyway, this is just part one of this journey and
Speaker:as I record this, I'm about to inject 7m.5mg dose
Speaker:of Zeppelin and God I still hate needles. I'll
Speaker:have more to share about the journey as we go, but
Speaker:don't worry, this is not going to become a
Speaker:zepbound podcast. I'm going to continue to bust
Speaker:myths about food and medicine to make sense of the
Speaker:madness. If you want to find out more, you can
Speaker:read about it on the blog associated with
Speaker:YourDoctorsOrders.com or ForkU.com and I am the
Speaker:guy who researched and wrote this. I'm Dr. Terry
Speaker:Simpson. I'm a board certified doctor but I am not
Speaker:your doctor and before you make any changes to
Speaker:your diet or if you get on zepbound, find a real
Speaker:obesity physician like Dr. Albert or whomever. Dr.
Speaker:Dalcy is a great one also in Michigan. Find them
Speaker:and talk with them. All things audio are done by
Speaker:my friends at Simpler media and the pod God
Speaker:himself, Mr. Evo Terra. And by the way, while
Speaker:weight loss isn't the big thing here, the big
Speaker:thing is the medical changes that it has made By
Speaker:Hemoglobin is A1C has gone down. It was normal but
Speaker:it's better. My blood pressure is down. It was
Speaker:normal. It was better. Lots of things are down.
Speaker:They're normal but better. But the weight down is
Speaker:good, because if I were to die tomorrow, then Mr.
Speaker:Evo, Tara would probably be one of my pallbearers,
Speaker:and at least he would have less to work with. All
Speaker:right. Eat smarter, live better. Leave guilt out
Speaker:of the kitchen. This is Dr. Simpson. Have a good
Speaker:week. Hey, Evo. I know, uh, you may be a
Speaker:pallbearer, but I'm gonna make an ash out of
Speaker:myself and be cremated. I hope you're doing well,
Speaker:buddy. How do you like this for true confessions?
Speaker:Yeah, it's not every day you hear boomers being
Speaker:all vulnerable and stuff, but I'm proud of you,
Speaker:man. And also, while we're in the sharing mode, I,
Speaker:too, have been on the shot for, gosh, about a year
Speaker:now, doing much better. I love it this way.