Andrea Stefani, co-founder of OnCoSwab, is revolutionizing lung cancer detection through innovative, non-invasive testing methods. With lung cancer being the leading cause of cancer death globally, Andrea's work aims to simplify and enhance early diagnosis, echoing the success factors of COVID testing. Her journey began at a young age, fueled by a vision to impact global health, and she has already made significant strides as a recognized scientist in Europe. Throughout the conversation, Andrea shares her experiences as a female entrepreneur in STEM, the challenges she faced, and her commitment to inspiring the next generation of women in science. Join Jothy Rosenberg as he delves into Andrea's inspiring story of grit, determination, and the pursuit of making a difference in the world of healthcare.
Andrea's Bio
Andrea Stephany Díaz is a visionary entrepreneur and the Co-founder of OncoSwab. Selected as a top 100 young scientist in Europe, she stumbled upon a cancer screening idea that led her to start her first diagnostic company at the age of 24. Andrea pursued a Master’s degree in molecular biotechnology with a goal of making an impact in global health. Today, lung cancer is the leading cause of cancer death in the world, fueling Andrea's strategic vision for early detection with OncoSwab. Andrea brings a wealth of expertise and passion to these topics, making her an engaging and insightful guest for discussions on entrepreneurship, healthcare innovation, and the transformative potential of OncoSwab. Andrea is also committed to inspiring the next generation of young people, particularly women, in STEM through her YouTube channel, DNAndrea.
Takeaways
Sound Bites
"I was selected as in the top 100 young scientists."
"I want to make sure that it's like, or find out if it's viable."
"The survival rate for lung cancer is currently around 20%."
Links
Andrea’s LinkedIn: https://www.linkedin.com/in/andreastephanydiaz/
Andrea’s OncoSwab site: https://oncoswab.com/
Please leave us a review: https://podchaser.com/DesigningSuccessfulStartups
Tech Startup Toolkit (book): https://www.amazon.com/Tech-Startup-Toolkit-launch-strong/dp/1633438422/
Site with all podcasts: https://jothyrosenberg.com/podcast
Jothy’s non-profit: https://whosaysicant.org
Jothy’s TEDx talk: https://www.youtube.com/watch?v=PNtOawXAx5A
Chapters
00:00 Introduction and Background
02:51 Recognition as a Young Scientist
06:11 Startup Journey and Lung Cancer Diagnostics
11:47 Understanding Lung Cancer and Its Causes
15:12 The Vision for OncoSwap
18:57 Navigating FDA Approval and Clinical Trials
20:47 Empowering the Next Generation of Women in STEM
25:02 The Role of Grit in Entrepreneurship
39:13 Conclusion and Call to Action
Hello, I'm Jaffi Rosenberg, the host of Designing Successful Startups, where today's guest is Andrea Stefani.
Andrea Stefani:What would be the simplest way on earth to get tested for a disease like lung cancer?
Andrea Stefani:For that we had to compare what, you know, our ideas to what has successfully happened in the world.
Andrea Stefani:So what is one disease that we all know that everybody got tested for?
Jaffi Rosenberg:Covid Andrea Stefani Diaz is a visionary entrepreneur and the co founder of OnCoSwab.
Jaffi Rosenberg:Selected as a top 100 young scientist in Europe, she stumbled upon a cancer screening idea that led her to start her first diagnostic company.
Jaffi Rosenberg:At the age of 24, Andrea pursued a master's degree in molecular biotechnology with a goal of making an impact in global health.
Jaffi Rosenberg:Today, lung cancer is the leading cause of cancer death in the world, fueling Andrea's strategic vision for early detection with Onco Swab.
Jaffi Rosenberg:And here is Andrea.
Jaffi Rosenberg:Hi, Andrea.
Jaffi Rosenberg:Hi.
Andrea Stefani:How are you?
Jaffi Rosenberg:My first question is always, where are you originally from and where do you live now?
Andrea Stefani:Wow.
Andrea Stefani:Well, so I am from Venezuela originally.
Andrea Stefani:I was born in an island in the Caribbean, even though I am way too pale to be Caribbean.
Andrea Stefani:I know, but that's where I was born.
Andrea Stefani:And then my, I'm half German, half Spanish originally.
Andrea Stefani:And then my mom decided to go back to Spain and take us back to Spain.
Andrea Stefani:So we did that when I was around 12 years old.
Andrea Stefani:So finished sixth grade and then moved to Spain, moved to Madrid, lived in Spain essentially my whole life after that.
Andrea Stefani:So I, almost all of my memories are there.
Andrea Stefani:So definitely when people ask me where I'm from, it's a kind of a long answer, as you can see.
Andrea Stefani:And now that I now live in San Francisco, California because of obviously the.
Jaffi Rosenberg:Startup, one of your honors is that you were selected as a in the top 100 young scientists in Europe.
Jaffi Rosenberg:How did that come about?
Andrea Stefani:So that was actually for a program that the European Commission organized to bring 100 young scientists from all over Europe to come up with solutions to societal challenges.
Andrea Stefani:All linked to the Horizon Europe mission.
Andrea Stefani:Right.
Andrea Stefani:So like sustainability, oceans, smart cities, and of course cancer.
Andrea Stefani:So I applied to participate in the Cancer mission program of that program.
Andrea Stefani:And honestly, it's an interesting story how I ended up there.
Andrea Stefani:I saw an Instagram ad.
Andrea Stefani:That's how it all started actually.
Andrea Stefani:I was scrolling through Instagram and then I saw this ad, something like, something like disruptive minds needed.
Andrea Stefani:That was what the ad said.
Andrea Stefani:I was like, sure, I'll click on it.
Andrea Stefani:And then I saw it was for this very competitive competition, like a hackathon, if you will.
Andrea Stefani:And I hesitated because up until that point I was 24.
Andrea Stefani:Then up until that point, I was the kind of person that would apply to like summer programs and internships at like the best places, et cetera.
Andrea Stefani:And I never got.
Andrea Stefani:I never got in.
Andrea Stefani:So I was like, why are we gonna apply?
Andrea Stefani:I know I'm not gonna get in.
Andrea Stefani:And then the last day, like nearly the day of the deadline, I decided to apply.
Andrea Stefani:And I just gave it my best.
Andrea Stefani:I.
Andrea Stefani:I did the application, but with full of storytelling.
Andrea Stefani:So it wasn't just a yeah, this is my background.
Andrea Stefani:I studied biochemistry and this is why I wanted to be in the cancer mission arena.
Andrea Stefani:It was all about like my personal connection to the mission and my personal connection to wanting to create bigger impact, something that's bigger than myself.
Andrea Stefani:And I got in.
Andrea Stefani:And that's how all of this started.
Andrea Stefani:That's literally the reason why we're talking today.
Andrea Stefani:So I'm very glad I applied.
Jaffi Rosenberg:Did they care what language you applied in?
Andrea Stefani:I think it has to be in English because then they do a peer review selection process which wants to mimic, I guess, the.
Andrea Stefani:How science works in general.
Andrea Stefani:And I.
Andrea Stefani:And every.
Andrea Stefani:All of us, all of the participants or the applicants, we had to read other applicants application in the other missionary.
Andrea Stefani:So they all had.
Andrea Stefani:They were all in English.
Jaffi Rosenberg:And you have almost no accent.
Jaffi Rosenberg:You must have started learning English at a very young age.
Andrea Stefani:I did, yeah.
Andrea Stefani:My parents, that's something that they knew they wanted.
Andrea Stefani:They were like, my kids have to speak good English and multiple languages.
Andrea Stefani:I speak four languages.
Andrea Stefani:Everybody in my family speaks, like in my dad's side of the family, which is German, everybody speaks like three to four languages fluently.
Andrea Stefani:So that is something that I was very lucky to grow up in.
Jaffi Rosenberg:You talked to me about the first thing you did in terms of a startup or, you know, an idea for a startup was when you were 24, just like when you were applying for that honor.
Jaffi Rosenberg:And.
Jaffi Rosenberg:And that was a.
Jaffi Rosenberg:The first diagnostic start.
Jaffi Rosenberg:I mean, it was the first startup you did.
Jaffi Rosenberg:I guess you told me that you stumbled onto that.
Andrea Stefani:Yeah, so I can say I did.
Andrea Stefani:It was a team work and it was all actually a product of.
Andrea Stefani:There's a hackathon.
Andrea Stefani:So that's how we stumbled upon the idea.
Andrea Stefani:We were at this program which was completely focused on giving us the scientists that Everybody was under 35.
Andrea Stefani:So like young scientists with at least a master's degree.
Andrea Stefani:So it was between Master's and PhD.
Andrea Stefani:They were giving us the tools to design solutions, essentially just like design thinking.
Andrea Stefani:Right.
Andrea Stefani:And first we had to identify problems, in our case, within the cancer space.
Andrea Stefani:To us, that problem was the late diagnosis of particularly lung cancer, because lung cancer is that disease that is the number one cancer killer on the entire planet, but is not talked about as often, unfortunately, in comparison to other cancers.
Andrea Stefani:And the number one issue with that cancer is definitely the late diagnosis because of the nature of the organ.
Andrea Stefani:Right.
Andrea Stefani:It's just it takes too long for it to show symptoms.
Andrea Stefani:So if there was a way for us to make it incredibly simple for people to get tested for lung cancer, those statistics would automatically change, like, no questions asked.
Andrea Stefani:So what we did at this hackathon was reverse engineer the problem, if you will.
Andrea Stefani:So we said, what would be the simplest way on earth to get tested for a disease like lung cancer?
Andrea Stefani:For that, we had to compare what, you know, our ideas to what has successfully happened in the world.
Andrea Stefani:So what is one disease that we all know that everybody got tested for?
Andrea Stefani:Covid.
Andrea Stefani:So what are the success factors in COVID testing?
Andrea Stefani:Non invasiveness, ease of use, cost efficiency, proximity to your house.
Andrea Stefani:All of those things are what made it so easy for people to get tested for Covid.
Andrea Stefani:If we had to do the same process as we do now for lung cancer, then not as many people would have gotten tested.
Andrea Stefani:Right.
Andrea Stefani:Well, and of course, it was mandatory for a lot of us to get tested, but still.
Andrea Stefani:Right.
Andrea Stefani:So then we took all of those success factors, and we said, okay, what if we applied that to lung cancer diagnosis?
Andrea Stefani:And that's when the aha moment happened.
Andrea Stefani:I remember it was like 11pm or like 1am it was super late that day.
Andrea Stefani:And we were all working there at the hackathon.
Andrea Stefani:We're like, a nasal swab.
Andrea Stefani:A nasal swab for lung cancer.
Andrea Stefani:Not knowing if it was even viable or feasible biologically at all, we just had the idea.
Andrea Stefani:The least we could do is give it a try.
Andrea Stefani:And after the hackathon ended, I remember that night I couldn't sleep.
Andrea Stefani:The night after, I couldn't sleep.
Andrea Stefani:And I was just thinking about what the world would look like if you.
Andrea Stefani:I mean, back then, that was the idea back then.
Andrea Stefani:Now, of course, we've pivoted from that.
Andrea Stefani:If you, let's say, go to a COVID testing facility and you tick a box and you're like, yes, test me for lung cancer as well.
Andrea Stefani:Wow, that would be incredibly easy.
Andrea Stefani:So I said to my team, I want to do this.
Andrea Stefani:I want to at least give it a shot.
Andrea Stefani:I want to make sure that it's viable or find out if it's viable.
Andrea Stefani:And Then now my now co founder Pablo, who was doing a postdoc at a time, his second postdoctoral, he was like, I'm, I, I'm in like I also can't sleep.
Andrea Stefani:I also can't stop thinking about it.
Andrea Stefani:And then him and I started what.
Jaffi Rosenberg:Is now I had lung cancer when I was 19, but I think it's different because mine was just a metastasis from the, the bone cancer.
Jaffi Rosenberg:So I'm pretty sure that it, but just check me on this, that it would be behave differently than the most of the types of lung cancer you're trying to diagnose.
Andrea Stefani:Yeah, we focus on primary lung cancer.
Andrea Stefani:So cancers that originate in the lung.
Jaffi Rosenberg:Is the reason that it's the number one cancer killer because of smoking?
Andrea Stefani:That's a fantastic question.
Andrea Stefani:So 80% of the lung cancer cases are caused or directed or related to smoking.
Andrea Stefani:So yes, smoking is a hugely contributing factor, which is incredible to think about.
Andrea Stefani:It's, it's, it's incredible to think about the fact that the number one cause of cancer death could be completely avoided.
Andrea Stefani:That being said, it's such a big problem in our society, lung cancer, that that remaining 20% is still the number 5th most common diagnosed cancer in this country, meaning non smoker lung cancer is still the number fifth most common cancer.
Andrea Stefani:So yes, smoking is a hugely contributing factor.
Andrea Stefani:However, it's important to understand that not all of it is related to smoking.
Andrea Stefani:And the reason why I think it's important is because it helps us destigmatize lung cancer, which has been the case for decades.
Jaffi Rosenberg:People are smoking way more than what we're seeing now in the United States.
Andrea Stefani:Well, there's a couple of things here.
Andrea Stefani:First, despite the fact that in the United States there has been tremendous progress on reducing smoking rates, it's still not the case in every state.
Andrea Stefani:Kentucky, West Virginia, Arkansas still have incredibly high rates, especially lung cancer, because of the smoking habits.
Andrea Stefani:And then another thing is, again, despite that fact, lung cancer is causes more death in the United States than prostate cancer, breast cancer and colon cancer combined.
Andrea Stefani:So it's still a very, very prevalent issue in this, in this particular side of the world now in Europe.
Andrea Stefani:You're completely right.
Andrea Stefani:It surprises me as a young person.
Andrea Stefani:I am with my friends in Spain and we're a table full of 12, 15 people.
Andrea Stefani: ne that is not smoking today,: Andrea Stefani:My mom smokes, my sister smokes.
Andrea Stefani:Like it's, it is a big issue.
Andrea Stefani:You're right.
Andrea Stefani:I really hope that awareness in this Space changes this when I obviously I'm my friend's worst nightmare because I literally do long cancer research for a living and every time I'm with them and they're smoking, I just give, I just have to tell them, but I just need to tell them, obviously.
Andrea Stefani:And everybody says the following.
Andrea Stefani:And I'm sure you've heard this.
Andrea Stefani:Oh, when my grandma smoked 17 packs a day for 95 years and she never, she never got lung cancer.
Andrea Stefani:And then another, my neighbor never smoked a day and had lung cancer.
Andrea Stefani:Like people just cherry pick the statistics again, because it's not something we talk about often because there's so much shame.
Andrea Stefani:So I really hope to see.
Andrea Stefani:Well, actually we are seeing increasing amounts of awareness done in this space because of that same reason.
Andrea Stefani:Now, again, smoking is not the only cost.
Andrea Stefani:There is actually increasing numbers of women in their 40s that have never smoked that are getting lung cancer.
Andrea Stefani:This number particularly is increasing and we still cannot pinpoint the exact origin for this situation.
Jaffi Rosenberg:Hi.
Jaffi Rosenberg:The podcast you are listening to is a companion to my recent book, Tech Startup Toolkit, how to Launch Strong and Exit Big.
Jaffi Rosenberg:This is the book I wish I'd had as I was founding and running eight startups over 35 years.
Jaffi Rosenberg:It's like a memoir of my entrepreneurial journey.
Jaffi Rosenberg:I tell the unvarnished truth about what went right and especially about what went wrong.
Jaffi Rosenberg:It's for the founder, the CEO and wannabe founders of tech and non tech startups.
Jaffi Rosenberg:You could get it from all the usual booksellers and also from the publisher@manning.com.
Jaffi Rosenberg:i hope you like it.
Jaffi Rosenberg:It's a true labor of love.
Jaffi Rosenberg:Now back to the show.
Jaffi Rosenberg:So, Uncle Swab, am I saying it right?
Andrea Stefani:You are.
Andrea Stefani:Yes.
Jaffi Rosenberg:Okay.
Jaffi Rosenberg:Okay, good.
Jaffi Rosenberg:If you're successful with this, which I'm sure you will be, you're one of the top 100 young scientists in Europe.
Jaffi Rosenberg:How will that change the world?
Jaffi Rosenberg:I mean, what kind of describe for us what that will mean?
Andrea Stefani:So the survival rate for lung cancer in the United States is currently around 20%, which is an all time high.
Andrea Stefani:In other countries, including Europe, it's even less than that.
Andrea Stefani:Right now.
Andrea Stefani:If somebody comes to you and says, I've been just, I've just been diagnosed with lung cancer, it's terrible news.
Andrea Stefani:It's news that nobody wants to hear.
Andrea Stefani:However, when it's detected at stage one or even stage two, the probabilities of survival can be up to 90%, 95%.
Andrea Stefani:That means that it's not a deadly disease when diagnosed early.
Andrea Stefani:So the vision we have for Onco swab is for it to become so widespread and in Poll's early diagnosis, to get to a point in society where if somebody goes to you and says, oh, I had, I've just been diagnosed with lung cancer, you're like, okay, so what are the next steps?
Andrea Stefani:What are you going to do?
Andrea Stefani:When are you going to start treating?
Andrea Stefani:It is not a death sentence anymore.
Andrea Stefani:That is the vision we have with OnSwap.
Andrea Stefani:And we are very certain that by bringing people closer to lung cancer detection and not expecting the other, the other way around to happen, that's something that is very, very feasible.
Jaffi Rosenberg:When you detect it that early, do they even do surgery or they just do a, A, a chemo treatment?
Andrea Stefani:Um, so it depends.
Andrea Stefani:This depends on the size of the nodule.
Andrea Stefani:This depends on the stage.
Andrea Stefani:Um, it can be resectable if it's small enough, if it hasn't been spread at all.
Andrea Stefani:So the surgery is definitely an option.
Andrea Stefani:And that is really the best option because then the tumor is removed and that is the best scenario, really.
Andrea Stefani:Um, other.
Andrea Stefani:Otherwise they do start chemo.
Andrea Stefani:But that again will depend on the stage of diagnosis.
Andrea Stefani:Because, because starting chemo, you know, the earlier the better, for sure.
Andrea Stefani:But then you want to have the tumor as localized and as control as possible because that will of course, increase the likelihood of success of the treatment.
Jaffi Rosenberg:And how far along are you on the creation of the, you know, the nasals, the nasal swab test, and you know, what, false positives, false negatives, where stage is it at?
Andrea Stefani:Yes, the stage is very, very early.
Andrea Stefani:We have preliminary clinical data, a proof of concept that was conducted in lung cancer patients and in healthy individuals.
Andrea Stefani:And now we're taking that proof of concept data and exactly the same technology and applying it to the first intended, intended use population, which is patients with pulmonary nodules.
Andrea Stefani:What does that mean?
Andrea Stefani:That means that maybe, let's say somebody falls off a bike or they have a car accident, something completely unrelated to anything that has to do with lung.
Andrea Stefani:They will likely be taken for a CT scan or some sort of imaging, chest CT scan, something, something of the.
Andrea Stefani:Like, what if that person is seen to have a nodule, a little shadow in their lung?
Andrea Stefani:That person is going to be told that that might be lung cancer, although it probably isn't, especially if it's a young, fit, healthy person.
Andrea Stefani:Right.
Andrea Stefani:It probably won't.
Andrea Stefani:But that means that now the patient will have this worry of, do I have lung cancer?
Andrea Stefani:Like, is there a chance I have lung cancer?
Andrea Stefani:And also that nodule, that patient with a nodule is added into the system.
Andrea Stefani:And now a doctor has to review manually each case and decides and decide which ones will go to biopsy.
Andrea Stefani:Okay, which ones will go to biopsy, which ones will be observed.
Andrea Stefani:What happens right now is that 50%, around 50% of biopsies could be avoided, meaning that the patient is subject to a invasive.
Andrea Stefani:An invasive procedure, but then it's not cancerous, it's a benign.
Andrea Stefani:It's something completely different.
Andrea Stefani:It can be even pneumonia.
Andrea Stefani:It can be tuberculosis, less likely, but it could be other things other than lung cancer.
Andrea Stefani:So that is our first application because that means that our test will be able to help risk, stratify the risk of that nodule being, to answer your question about false positives, false negatives, we are still very early in the process and cannot disclose yet any information about the clinical trials.
Andrea Stefani:But once that is achieved, the bigger clinical trials achieved around maybe in a year.
Andrea Stefani:For now, we'll be able to talk about more publicly about sensitivity and specificity data.
Jaffi Rosenberg:Because this is non invasive, your FDA approval path is not very difficult, isn't that right?
Andrea Stefani:Well, I don't know if I would call it not very difficult or my investors would like me to call it that.
Andrea Stefani:Yes.
Andrea Stefani:So it's easier than if you compare it to therapeutics.
Andrea Stefani:Therapeutics company, 100%.
Andrea Stefani:If you compare it to a company that's doing like bromcoscopy analysis, like the sample needs to be taken during bronchoscopy.
Andrea Stefani:100%.
Andrea Stefani:It is very noninvasive.
Andrea Stefani:However, we need to think about the possible outcome of the patient.
Andrea Stefani:If the patient is told to be negative for our test and is not subject to biopsy, that will be detrimental for the patient.
Andrea Stefani:Right.
Andrea Stefani:If the patient is said to be positive for the test and is subject to a, an invasive procedure that could have otherwise been avoided, it's also detrimental for the patient.
Andrea Stefani:So that is where risk relies.
Andrea Stefani:That is why we need strong, good, thorough data to help us with our FDA case.
Andrea Stefani:So if that is good, if the data looks good, if the data is solid, the clinical trial is successful, then yes, and we have a good case.
Jaffi Rosenberg:Yeah, you're still very young, but you're already thinking about the next generation and you've got some ways in which you're trying to positively influence the next generation of women, in particular around STEM.
Jaffi Rosenberg:And maybe that's another chance to change the world 100%.
Andrea Stefani:Well, it all stems, no pun intended, from the fact that I feel like I grew up with a lack of role models, female role models in this space, in the space where I'm currently at.
Andrea Stefani:And I feel like there are so many incredible female founders that are changing this in my goal.
Andrea Stefani:I remember one of the first interviews I ever did for a magazine, they asked something about female founders.
Andrea Stefani:And I think the article was about female founders.
Andrea Stefani:And I said in one of the questions, honestly, I really hope that there is a day where we don't have to say she's a female founder.
Andrea Stefani:Like, this is a female founder.
Andrea Stefani:She's founder that happens to be a woman, happens to be a man.
Andrea Stefani:Because right now we are the minority.
Andrea Stefani:So we have to, we have to clarify that it's a female founder because it's out of the ordinary.
Andrea Stefani:But I think that we're slowly changing that.
Andrea Stefani:So, yeah, to your question about the next generation, I started a YouTube channel forever ago.
Andrea Stefani:I barely have any time to post there anymore.
Andrea Stefani:But it was this passion project of mine that, believe it or not, helped me a lot with the startup.
Andrea Stefani:And I'll tell you why in a second.
Andrea Stefani:This YouTube channel, DNA.
Andrea Stefani:Andrea, it's a funny name.
Andrea Stefani:I started when I was in college originally to talk about my experience studying biochemistry.
Andrea Stefani:And I don't know what that looked like, what you could do after studying biochemistry.
Andrea Stefani:Etc.
Andrea Stefani:My first video, which is really, really painful to watch and I hope I never have to again, is about.
Andrea Stefani:Yeah, that is very.
Andrea Stefani:Called Estudio Studying biochemistry.
Andrea Stefani:It started in Spanish and I switched to English.
Andrea Stefani:That was like for some reason my most watched video because a lot of people wanted to know about what it is like, like what do you do in that degree and what you do afterwards, et cetera.
Andrea Stefani:Is it hard?
Andrea Stefani:What do you need to do, et cetera.
Andrea Stefani:So.
Andrea Stefani:But a big, big desire of mine was for women, young women, maybe girls that are in high school still or middle school, to see that there's a lot of us girls that look like them doing this right now.
Andrea Stefani:I've transitioned to, of course, talk more about my entrepreneurial journey, which again is something that is one of my goals for next year.
Andrea Stefani:To do more of that just because I feel like again, back to my lack of role models when I was younger.
Andrea Stefani:I'd love to share my journey building this company as a young female and as a person in general, but especially targeting young females to see what this is like and to see that they can also do it.
Andrea Stefani:Why?
Andrea Stefani:Because I remember being 16 or so.
Andrea Stefani:I was living in Canary Islands at the time.
Andrea Stefani:I moved a lot.
Andrea Stefani:I've lived in many places.
Andrea Stefani:I didn't include that in my introduction, but I.
Andrea Stefani:We've moved around a Lot.
Andrea Stefani:Um, I was in the Canary Islands in high school, daydreaming about my future.
Andrea Stefani:And I always saw myself as this successful businesswoman I knew I wanted to be in science, but somehow, like, my God was telling me I was gonna be a businesswoman, and I didn't.
Andrea Stefani:I didn't know how to connect the two, to be honest.
Andrea Stefani:But I just.
Andrea Stefani:That's just how I saw myself.
Andrea Stefani:And then when I started getting very.
Andrea Stefani:Getting into this, the world of entrepreneurship and starting companies and all of that, I started following every podcast I could, reading every book I could, following every YouTube channel I could.
Andrea Stefani:All men, all guys.
Andrea Stefani:Especially in this space.
Andrea Stefani:In biotech, there were like zero women.
Andrea Stefani:The one woman was Elizabeth Theron, Elizabeth Holmes with Theranos.
Andrea Stefani:And we all know how that ended.
Andrea Stefani:So that's like, truly a shame that the one young woman in biotech that we know, I mean, now, now there are more, luckily, but back then that was like, the only example that the world knew of.
Andrea Stefani:So I feel like it was hard for me to envision myself doing what I'm doing now just because it was.
Andrea Stefani:I didn't see anybody else doing it.
Andrea Stefani:So I thought, okay, I will eventually start a company, I will eventually create a business, but because there's nobody else doing it, it must be really, really hard.
Andrea Stefani:Which means that I need a lot of credibility.
Andrea Stefani:And for credibility, I need time.
Andrea Stefani:So I'm going to get a PhD postdoc in the industry, work, blah, blah, blah.
Andrea Stefani:And when I'm 50 and people believe me, then I'll start a company.
Andrea Stefani:That's what I thought by then.
Andrea Stefani:And then, you know, obviously that's not what ended up happening.
Andrea Stefani:So I'd love to, you know, of course, inspire if I can in any way.
Andrea Stefani:The next generation of, yeah, we make.
Jaffi Rosenberg:A YouTube from this and as well as the Apple and Spotify and, and, and you can, you know, spread these to all the places where you.
Jaffi Rosenberg:You think you can, you know, inspire and influence on my podcast.
Jaffi Rosenberg:I think we're right.
Jaffi Rosenberg:About 50% of the guests are startup founding people who happen to be women.
Andrea Stefani:Thank you for saying it that way.
Andrea Stefani:I am very happy to hear that.
Andrea Stefani:That's awesome.
Andrea Stefani:I saw that in your podcast.
Andrea Stefani:I saw it in your website.
Andrea Stefani:I was curling bells.
Andrea Stefani:Like, there's a lot of women.
Andrea Stefani:I'm so happy.
Andrea Stefani:I noticed, you know, and the interesting thing is that when you're a woman, that's the first thing you notice.
Andrea Stefani:And the reason I know is because I always compare this with my co founder, who's a man.
Andrea Stefani:Like, we were in Chicago at a business dinner with like 20 people in a table and I was the only woman, the only woman.
Andrea Stefani:And nobody noticed.
Andrea Stefani:And I told five of them, I'm the only woman.
Andrea Stefani:It's like, oh, that's true.
Andrea Stefani:I think that's the first thing I see, you know, so I'm.
Andrea Stefani:Congratulations on that, by the way.
Andrea Stefani:I was, I was going to tell you for how the YouTube channel helped me with my startup.
Andrea Stefani:And I can tell you, but if you want.
Andrea Stefani:So one of the reasons, and the most important one is science communication skills.
Andrea Stefani:I had never thought it was going to be so helpful what I did in my YouTube channel.
Andrea Stefani:I have not that many videos, like over 30 or 40 videos.
Andrea Stefani:What I do is I study a very, very complex topic and I simplify it to make it very easy for people that not don't necessarily have a background to understand.
Andrea Stefani:And that on its own is a skill that now as CEO of a biotech company, I do every single day of my life.
Andrea Stefani:And it's helped me tremendously.
Jaffi Rosenberg:And you said your first one that you put up there was in Spanish, but then the others in English, I.
Andrea Stefani:Think most of them are in Spanish.
Andrea Stefani:And then that was a bad idea.
Andrea Stefani:I don't think this applies to anybody listening.
Andrea Stefani:But if anybody's thinking about doing a YouTube channel or has a YouTube channel and want to reach a broader audience and wants to switch to English, don't do it.
Andrea Stefani:Because it just messed up with my algorithm and my audience wasn't writing Spanish.
Andrea Stefani:I was being suggested to people in Spanish.
Andrea Stefani:Those videos in Spanish were doing very well.
Andrea Stefani:But then I felt like, you know, I then moved to Germany, I was working in English, I was doing everything in English and I kind of wanted to talk about these topics in English and also wanted to reach a wider audience.
Andrea Stefani:But the opposite ended up happening.
Andrea Stefani:And I definitely had a very big niche in the Spanish.
Andrea Stefani:Spanish speaking market.
Andrea Stefani:So for.
Andrea Stefani:For me to like be exposed to.
Andrea Stefani:So yeah, I ended up switching to English.
Andrea Stefani:But maybe.
Jaffi Rosenberg:So talk a little bit about the company itself.
Jaffi Rosenberg:It's called Ankos Oncoswab.
Andrea Stefani:Yeah.
Jaffi Rosenberg:For oncology.
Jaffi Rosenberg:It's very self explanatory what it is all about.
Jaffi Rosenberg:Right.
Jaffi Rosenberg:It's good.
Jaffi Rosenberg:And how many people and where are you sort of in terms of a stage?
Andrea Stefani:Yes.
Andrea Stefani:So we incorporated the company had the idea this hackathon.
Andrea Stefani: September: Andrea Stefani:Then it was just Pablo and I wandering around the world, figuring out what to do.
Andrea Stefani:We were completely lost.
Andrea Stefani:It was honestly a miserable time.
Andrea Stefani:I remember the first six months as being extremely painful.
Andrea Stefani:Just because it was really hard not knowing what to do but wanting to do it all and being highly motivated by nobody paying attention to you as it is at the beginning we had nothing, just had an idea.
Andrea Stefani:Zero money, zero, no company, nothing.
Andrea Stefani:So that was definitely very tough.
Andrea Stefani:But we made it out of there.
Andrea Stefani:Um, then we decided to Register a company.
Andrea Stefani: March: Andrea Stefani:Right.
Andrea Stefani:Like seeing that there's case.
Andrea Stefani:After we had talked to doctors that were interested, after we had talked to some payers, after we had done some market analysis and realized this was actually heading somewhere besides the science.
Andrea Stefani:Um, we raised the pre seed earlier this year, January, we're raising a seat now as we speak.
Andrea Stefani:Investors are coming in as we speak.
Andrea Stefani:So it's actually picking up now.
Andrea Stefani:It's going really well.
Andrea Stefani:As I said, we did the concept and now preparing to do clinical trials also as we speak.
Andrea Stefani:So like all of the doctors, we're starting off in Spain with hospitals in Spain and all of the doctors are like fully and super committed.
Andrea Stefani:It is such a blessing to be working with doctors that are extremely motivated to be a part of it, to bring the technologies to reality.
Andrea Stefani:So that's the stage of the company.
Andrea Stefani:The plans for all of next year is to do a clinical trial for the nodules and have a version of the test that is ready to launch in a very release approach, in a very limited release approach.
Andrea Stefani:Sorry to what will be our first adopters.
Andrea Stefani:That part of the strategy is a bit kind of.
Andrea Stefani:We kind of not disclose it so openly.
Andrea Stefani:But the part of the stage of the company we're at is, I would say, yeah, seed preparing for clinical trials.
Andrea Stefani:What we've done so far is also recruit top professionals in the space, both lung cancer and liquid biopsy.
Andrea Stefani:As far as our advisory team and the team in itself were four, about to be five, so super tiny.
Andrea Stefani:But I love it.
Andrea Stefani:I actually love our company size.
Andrea Stefani:I was talking to an investor this morning about that and he was asking about our next hires and I was like as little as possible.
Andrea Stefani:Like honestly, you don't need to hire more people if you don't need it.
Andrea Stefani:I think we are completely overworked, but we're doing fine.
Andrea Stefani:We're laser focused and I feel like increasing the team size in a way that doesn't relate to the stage you're at can be more of a distraction than a solution.
Andrea Stefani:So we're probably going to keep the team size fairly small.
Andrea Stefani:Maybe hire one or two more people for the next round.
Andrea Stefani:Yeah, that's where we're at.
Jaffi Rosenberg:And you're finding investors where in California, in the San Francisco area?
Andrea Stefani:Everywhere, yes.
Andrea Stefani:So definitely mostly here in San Francisco.
Andrea Stefani:But so some of the VCs that we're talking to, I just don't want to disclose too much, but some of them are in North America, some of them are in the uk, some of them are in Germany.
Andrea Stefani:And I think that's about it.
Andrea Stefani:All of the countries that we're covering.
Andrea Stefani:And then we also have angel investors that are coming in at this round or that have already come in at this round.
Andrea Stefani:And those are also the countries I mentioned, plus Europe, like other countries in Europe, like Switzerland, like Spain for example.
Jaffi Rosenberg:And have you, have you.
Jaffi Rosenberg:Are you bringing in any strategic investors at this early stage or are that's going to be for later or, or maybe not.
Andrea Stefani:No, no.
Andrea Stefani:100% super interested in strategic investors.
Andrea Stefani:We are talking to them, but we're not bringing them in yet just because it's a little too early.
Andrea Stefani:In general, however, despite the earliness, it's important for us to know what they want, what they want to see, which is why we're talking and also see if there is a market at all.
Andrea Stefani:So I believe that after the first set of data we get, then we could talk about a partnership or investment, but not for the time being.
Jaffi Rosenberg:I think anybody who's been watching this, including me, would say you're very gritty.
Jaffi Rosenberg:You've got a lot of grit.
Jaffi Rosenberg:Right?
Jaffi Rosenberg:You would agree?
Andrea Stefani:I would say so.
Andrea Stefani:I would agree.
Jaffi Rosenberg:Where do you think it comes from?
Jaffi Rosenberg:Because it sounded like you had it when you were 24, you probably had it before that.
Jaffi Rosenberg:So where do you think it came from?
Andrea Stefani:Oh my God.
Andrea Stefani:So I have to say it has to come from.
Andrea Stefani:If I have to say one reason, it's probably being a third culture kid.
Andrea Stefani:So being an immigrant, becoming an immigrant at such a young age, always feeling like you don't belong.
Andrea Stefani:Like every city I've been in, every place I've lived in, I've always felt like an outsider.
Andrea Stefani:And that is sounds like something bad, but it's a blessing truly because that allows you to see things differently.
Andrea Stefani:So as I said, have German, have Spanish, just born in Venezuela.
Andrea Stefani:I was literally born in a third world country where you can either be rich or poor, there's no in between.
Andrea Stefani:And if you have access to a foreign currency, then you live like a king or queen, literally.
Andrea Stefani:So I.
Andrea Stefani:That's.
Andrea Stefani:That that was my childhood.
Andrea Stefani:Like I was very well off.
Andrea Stefani:And then I moved to Spain with a mom that was a Single mom, a little sister in me.
Andrea Stefani:And it turns out we were no royal family.
Andrea Stefani:We were just like regular citizens.
Andrea Stefani:In fact, honestly struggled a lot throughout my, my teenage years.
Andrea Stefani:Lots of like, mental health issues in my family, layoffs, financial problems.
Andrea Stefani:We moved a lot again, for those same reasons.
Andrea Stefani:By the time I was 23, I had already lived in seven different places with, again, different languages.
Andrea Stefani:So it's that ability to constantly adapt one thing.
Andrea Stefani:And the second thing is I think that it's funny when I talk to people about what I'm doing and I hear the comment, which I'm sure you've also heard a lot in your journey, it's so unbelievable, the risk you're taking, it's so honorable, you're so brave, which is super well meant and I really appreciate it when people say that.
Andrea Stefani:But to me, I.
Andrea Stefani:I've never fully understood that comment, you know, like the risk, the risk I'm taking.
Andrea Stefani:What risk?
Andrea Stefani:I have been through a lot in my life.
Andrea Stefani:I really, I've grown up without having much.
Andrea Stefani:So what would be the worst thing that could happen out of this incredible journey that I'm in?
Andrea Stefani:What happens if I lose it all?
Andrea Stefani:It's okay.
Andrea Stefani:I've been there.
Andrea Stefani:I'm young, I can reinvent myself.
Andrea Stefani:There's no risk.
Andrea Stefani:To me, the bigger risk would be not starting at all, you know, So I think that's a little bit where it comes from.
Andrea Stefani:Having seen so much of the world and throughout so many different lenses, feeling like the sky isn't even the limit.
Andrea Stefani:Like there is no limit, you know, And I'm so, so, so grateful now.
Andrea Stefani:You know, in hindsight, seeing every.
Andrea Stefani:Everything I've been through is for a reason, because it's made me the person I am today.
Andrea Stefani:I hope that answers your question.
Jaffi Rosenberg:Well, it's a phenomenal answer to my question and a very inspiring answer.
Jaffi Rosenberg:That's great.
Jaffi Rosenberg:I wish some of the people who are against all immigration would hear what you're saying.
Andrea Stefani:Actually, it's a pity, because immigrants, the whole thing with immigration in the us it's a whole topic on its own.
Andrea Stefani:Where I'm from, in Spain, it's a huge topic as well.
Andrea Stefani:And when you're an immigrant, you're raised differently.
Andrea Stefani:When you're an immigrant, you see the world differently.
Andrea Stefani:You have to fight to survive regardless of how well off you are.
Andrea Stefani:Like, let's say you immigrate.
Andrea Stefani:Like, for example, I immigrated to Spain with a Spanish passport.
Andrea Stefani:I consider myself incredibly lucky because of that sole reason, because I was able to be a citizen of the country I was living in, that is luxury.
Andrea Stefani:Still, you're an immigrant.
Andrea Stefani:Still, you're an outsider.
Andrea Stefani:Still, you need to adapt.
Andrea Stefani:That is an incredible skill that you take for the rest of your life.
Andrea Stefani:The first time I saw that is when, again, I was 24 starting this company.
Andrea Stefani:And all of a sudden I was at the J.P.
Andrea Stefani:morgan conference, the healthcare conference, in rooms with people that were twice my age, had 30 more years of business experience than I did, that actually knew what they were doing.
Andrea Stefani:And I was in the same room as them.
Andrea Stefani:And I had to somehow impress them.
Andrea Stefani:I had to somehow convince them to help me with something that not even I knew what I was doing, right?
Andrea Stefani:But it's that ability to adapt that I've had my whole life that made me succeed in those roles and actually somehow convince people that are important to give me time of the day.
Andrea Stefani:You know, I would not have had that if I would have lived my whole life in the same city and I would have been handed everything I had in my life that would have simply never happened.
Jaffi Rosenberg:Listeners are going to love hearing your story this episode.
Andrea Stefani:I really hope so.
Andrea Stefani:And if anybody watching wants to know more, if anybody's in a similar position where they're thinking, oh, I really want to start something.
Andrea Stefani:But I don't know, I'm scared.
Andrea Stefani:I'm too afraid.
Andrea Stefani:What if?
Andrea Stefani:What if?
Andrea Stefani:I'm always happy to pop in a call, talk about it, vent if you will.
Andrea Stefani:So very happy to tell.
Jaffi Rosenberg:That's a wrap.
Jaffi Rosenberg:Thanks for tuning into this week's episode of the Designing Successful Startups podcast.
Jaffi Rosenberg:Check out the show notes for resources and links.
Jaffi Rosenberg:Please follow and rate us@podchaser.com designing successful startups.
Jaffi Rosenberg:Also, please share and like us on your social media channels.
Jaffi Rosenberg:This is Jothy Rosenberg saying TTFN ta ta for now.