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#67: The Omega-3 Advantage: Dr. William S. Harris on Fighting Inflammation & Boosting Health
Episode 6712th May 2025 • Beyond the Pills • Josh Rimany
00:00:00 00:44:14

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Is your body getting enough Omega-3s? The answer might surprise you.

Inflammation is a silent killer. It plays a key role in chronic diseases like heart disease, cognitive decline, joint pain, and even depression—yet many people don’t realize that something as simple as their omega-3 levels could be the missing piece to better health.

On this episode of Beyond The Pills, host Josh Rimany sits down with one of the world's foremost experts in omega-3 research, Dr. William S. Harris, PhD, FASN. With over 40 years of groundbreaking research, 300+ scientific papers, and contributions to multiple American Heart Association statements on fatty acids and heart health, Dr. Harris has changed the way we understand the role of omega-3s in reducing inflammation, supporting heart and brain health, and improving overall wellness.

As the co-inventor of the Omega-3 Index and founder of OmegaQuant Analytics, Dr. Harris brings cutting-edge insights into why measuring your omega-3 levels could be the key to unlocking better health. We’ll explore:

✅ What the Omega-3 Index is and why it matters

✅ The connection between omega-3s and inflammation, heart disease, and cognitive function

✅ How you can optimize your health by balancing your fatty acid levels

✅ The latest research on omega-3s and what the medical field is missing

If you’ve ever wondered whether you’re getting enough omega-3s or how they can dramatically impact your well-being, this is the episode for you. Tune in and take the next step toward better health—beyond the pills!

🌐 Learn more at: www.omegaquant.com | www.faresinst.org

Transcripts

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All right.

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Hello.

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Hello.

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Welcome to this episode of

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Beyond the Pills.

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I'm Josh Rimini, pharmacist turned healer.

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And today I have a very special guest,

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Dr. Bill Harris,

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who has been the leading

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researcher in the

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omega-three fatty acid

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field for over forty years.

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He has over three hundred

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scientific papers on fatty

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acids and health and the

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vast majority on omega-three.

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He has been on the faculty

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of three medical schools,

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the University of Kansas, Missouri,

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at Kansas City, and South Dakota,

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and has received five NIH

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grants to study omega-three.

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He was also the co-author on

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three AHA statements on

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fatty acids and heart health.

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We'll talk a lot about that.

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As the co-inventor of

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the omega-three index and

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other omega-three blood

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tests in the founder of

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OmegaQuant Analytics.

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Dr. Harris has been ranked

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among the top two percent

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of scientists worldwide

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based on the impact of his research.

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Welcome.

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Welcome, Dr. Bill Harris.

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Thank you so much for coming.

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You bet, Josh.

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Great to be here.

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Nice to talk with you.

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Man, I've

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As the pharmacist who turned

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un-pharmacist going to

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functional medicine,

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I learned a lot about omega-three.

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And recently, let's say the last ten years,

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learned about omega-three indexing.

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And so I'm very proud and

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privileged and honored to

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have the co-founder,

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co-creator of the omega-three indexing.

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And I want to jump right in.

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I want to talk about...

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your story and how you got into all this.

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Oh, how did I get into all this?

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Well,

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I was told by my mentor to get into this.

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This was back in nineteen seventy nine.

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I was finished.

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I had finished a Ph.D.

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in nutrition at the

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University of Minnesota,

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and I went to Portland, Oregon,

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Oregon Health Sciences

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University to do a

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postdoctoral fellowship

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with a scientist named Bill Connor.

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And Bill was very interested

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in the effects of different

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dietary fats on cholesterol

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levels back in the late seventies.

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And he was particularly

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curious about what would

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happen if you fed people a

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lot of fish oil,

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as opposed to plant seed

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oils or solid fats, like saturated fats,

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butter, meat, things like that.

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he said you know fish fish

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oil is a liquid oil at room

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temperature like plant oils

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are but it comes from an

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animal not a plant and so

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we knew the plant plant

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oils are liquid and they

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lowered cholesterol levels

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but the in the saturated

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fats and animal fats raise

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cholesterol so bill was

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curious about here's this

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animal liquid oil what does

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it do to people so that was

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my assignment and I took me

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a couple of years to do a

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a trial where we fed people

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we recruited students uh

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fed them different diets

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for one month at a time we

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fed them a whole bunch of

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salmon oil that was our oil

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of the day back then and uh

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I mean a whole bunch

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meaning all virtually all

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their fat from salmon oil

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so it was huge they you

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know like a half like a

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half a cup a day of salmon

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oil that they just drank which was

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Pretty gross, but they did it.

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Anyway,

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we found out that the cholesterol

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level did go down on the

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salmon oil diet like it did

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on the vegetable oil diet

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relative to the saturated fat diet.

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And so that was fine.

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It didn't go down a lot,

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but these were healthy people.

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But the triglyceride levels

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dropped pretty substantially,

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and that was kind of a surprise.

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That was the first kind of

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discovery that omega-threes

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lowered triglycerides.

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But that put me into

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learning about salmon oil

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and about the same time

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that the Danish Greenland

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Eskimo studies were being

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published about how it

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seemed like there's

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something about these

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omega-threes that reduce

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risk for heart disease in Eskimos.

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And so I started to learn

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more about that and started

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to look at blood coagulation platelet

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platelet action, platelet inhibition,

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because the omega-threes did that too.

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We didn't know what the

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mechanisms were of how the

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omega-threes lowered risk,

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but we were starting to

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explore it back there in

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the early eighties.

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And I've been pretty much,

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I guess the first half,

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first twenty years of my career,

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I was interested in giving

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people fish oil and see what it did,

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sort of intervention studies.

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But then

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with the creation of the omega-three index,

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which we'll talk about a little bit later,

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which is a blood test,

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I got more interested in the question,

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what do omega-three blood

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levels tell us about future

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risk for disease?

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That's huge.

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I've become more in the epidemiology side,

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studying populations,

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studying blood levels and

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predictions than actually

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giving people fish oil and

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testing what it does to them.

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And let's let's talk a

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little bit about that little like,

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you know, for the listeners out there,

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we're talking omega three fatty acids,

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right?

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They're coming from

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predominantly fish and what

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fish eat right from the

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algae and things like that.

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Right.

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And so and we know that

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omega threes are healthy.

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We know that fish oils are healthy.

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And for cardiovascular reasons,

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even to the point where

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pharma has created SLS

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versions of these things

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and moved them in that right.

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But this is like, I'm hearing,

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for the years we've known

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that these things have been

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pretty good for our health,

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yet I feel like we still

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scratched the surface on

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the awareness of its importance.

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And so I wanted you to talk

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a little bit about

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omega-three and the other omegas and what,

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cause you're the expert here, right?

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We want people to understand

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that there are different omegas and they,

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they,

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they're in the body for certain

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reasons and the ratios are important,

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but talk to people a little about the,

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about the mega fatty acids.

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Cause I think it's really

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important just to get a baseline here.

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Yeah, sure.

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And when we say, and this is very common,

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this is called omega fatty acids,

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but there's,

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Lots of omega fatty acids.

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Omega-three fatty acids, one family.

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Omega-six fatty acids is another family.

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Omega-nine is another family.

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So when I talk about omegas,

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I'm talking about primarily

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omega-three fatty acids.

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And those are all related to

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each other chemically.

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The structure,

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chemical structure is similar.

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one part of the molecule,

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then the other part of the

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molecule differs.

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So it's like in a family,

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you've all got the same last name,

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but you have different first names.

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And that's the way it is

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with the omega-three and the omega-six.

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So in the omega-three family,

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there's a plant-based

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omega-three called alpha-linolenic acid,

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ALA.

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Typically,

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flaxseed oil has got quite a bit of it.

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Chia seed oil has some,

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but flaxseed is kind of the classic.

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Although most Americans get

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the ALA we get in our diets

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mostly comes from soybean oil.

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Because soybean oil,

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we consume so much of it in

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so many different forms,

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but it's got about five to

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six percent ALA in it.

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So that's the bulk of where

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we get it is from that.

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Most people are not taking flaxseed oil.

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So that's the plant omega-three.

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It's a shorter version of

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the fish oil omega-threes,

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which are EPA and DHA.

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ALA is converted to a small

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extent to those two longer chain,

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but that happens in the

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liver and it doesn't happen

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very efficiently at all.

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So you really can't raise

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your blood omega-three

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levels in any substantial way.

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You can't raise your omega-three index,

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EPA and DHA,

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by taking the plant omega-three.

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So our primary talk today

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probably will be about EPA and DHA,

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which are the,

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we call them marine or

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seafood-based omega-threes.

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Those originate, as you implied,

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they originate in the ocean.

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They're actually made by a

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very single-celled organism

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called microalgae,

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sometimes called phytoplankton.

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And

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that's where the real factory is,

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where they turn sunlight

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into these long chain fatty acids.

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And then really small filter

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feeders in the ocean will eat the algae.

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And then the small fish will

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eat the filter feeders.

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And then the big fish eat

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the little fish and up it goes.

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Because fish really don't

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make omega-three any more

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efficiently than we do.

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So they have to eat it just like we do.

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So when we

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Our best source of

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omega-three is preformed

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EPA and DHA from seafood.

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And so that's, I think,

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what we're really going to

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be talking about.

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Well,

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I think that's a really important point.

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And the second point that

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you made is these are

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essential fatty acids.

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In other words,

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we've got to eat them in

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order to get them.

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We don't manufacture them, right?

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Well,

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we don't manufacture the parent

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omega-three ALA.

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Mm-hmm.

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we can if we eat ala we can

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make some and we make

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probably enough epa and dha

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from ala to sustain life we

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don't make enough to give

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optimal health that's huge

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because we look at you know

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epa and dha are not dietary

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essentials they are uh

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they're bioactive molecules that are

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helpful in reducing risk for

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a lot of disease,

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but there are certainly

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human beings can live

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without eating any EPA, DHA preformed.

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If you're a vegetarian,

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if you're a vegan particularly,

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you're not eating because

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these just come from, I mean, yeah,

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there are products where

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you can get EPA and DHA from algal oil,

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but that's brand new in the world.

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typically vegans who eat no

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animal products at all don't eat any EPA,

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DHA.

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And yet they grow up, live, have children,

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reproduce so they can live.

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We just think they're at

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higher risk for a variety

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of chronic diseases for

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having low omega-three levels.

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And they do have low omega-three levels.

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So EPA and DHA are just, I think,

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bioactive nutrients that are helpful,

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but they're not essential.

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Well, it's important though, because

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What you're saying,

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because I love the word optimal, right?

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When I talk about

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optimization of nutrients,

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it's very different than

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let's call it RDA or the

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nutrient levels we need not

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to get a disease associated

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with the deficiency versus optimization,

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which is where I think

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we'll be going today

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because we have an omega

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three index testing.

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We can test the omegas in

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our body and we can see them.

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So it's a really clear point

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to make that we're trying

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to optimize health now.

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We're not trying to make a minimal amount,

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right?

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And because we need to

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ingest these at larger

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levels rather than relying

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on the systems to make the minimum levels,

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let's talk a little bit about,

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because everyone knows Fischl.

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It's the top three supplement in the world,

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right?

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these omega threes that we were using,

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I've been using them in

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practice for years.

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It was actually the first

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supplement omega three

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professional grade high

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quality omega three that's been

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was one of my first

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supplements when I started

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learning about nutrition as

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a pharmacist because we

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didn't really learn about

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this we learned about it in

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the arachidonic acid

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cascade and inflammation

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and things like that and

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then we learned about how

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the NSAIDs work but now

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that was my first

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supplement in learning

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about clinical nutrition

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and it was kind of it's now

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full circle because I'm

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using it so much more now

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from the perspective of

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If I had to give people

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certain things to make it

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really simple for their health,

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omega-threes at my top of

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my list because of all of those.

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Let's talk about the

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epidemiology and the health reasons.

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So you've studied this for so long, right?

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And you've seen these anecdotally,

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but you've seen them in all the studies.

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You've written three hundred papers.

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So what are the benefits

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here of omega-threes?

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Well, the benefits are different,

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different levels.

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We can certainly say that omega-threes,

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if you have, again, we're talking EPA,

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DHA.

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If you've got optimal levels of them,

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you're chronically

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suppressing inflammation.

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And I think that if you have

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to point to one thing,

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that's probably the most

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important thing they do,

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is reduce the whole tone of

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inflammation across the body.

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Multiple systems are all

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less inflammatory.

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And so that has implications

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on all kinds of diseases,

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which is why omega-threes

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seem to play a role in so

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many different maladies.

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But other things that they do,

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they do make the blood

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thinner in the sense that

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they will reduce

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the risk for platelet aggregation,

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which causes blood clots.

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And so that's a component of

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what they're doing.

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They don't do it to the

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point where you're

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increased risk for bleeding.

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Clinically significant

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bleeding doesn't happen

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with taking omega-three.

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But it's kind of like taking

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a baby aspirin in a way,

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because that will make your

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blood thinner as well.

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But you won't have some of

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the GI bleeds that you get

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from taking aspirin.

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You also lower triglycerides,

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something I mentioned earlier.

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Your blood levels of

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triglycerides are going to

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be lower if you've got high omega-threes.

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And blood pressure has been

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reduced by omega-threes in

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randomized trials.

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So those are kind of

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biochemical mechanisms by

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which they work.

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But at the end of the day,

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they reduce risk for a

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variety of diseases,

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which is where we kind of

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come up with the

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The epidemiology is what's

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showing us how a high

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omega-three is chronically

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associated with a lower

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risk for a variety of

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chronic disease outcomes.

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And so that's why we think they're good.

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Well,

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and you touched on the really

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beautiful point here,

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which is inflammation, right?

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The root cause of almost all

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the chronic conditions is this

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it's kind of like

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omega-threes are at the top

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of the level here because

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it's lowering inflammation

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on the global level in the body.

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So all these downstream effects,

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when we talk about it in a

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functional perspective,

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is like cardiovascular

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system and all the other

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downstream effects to

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inflammation or inflaming body,

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which is high inflammation, becomes

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lower because we're

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improving that status in the bloodstream,

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right?

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Because the mega three index

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testing in the blood.

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So I love that you brought

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that up from the beginning

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because it's not like we're taking,

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because a lot of people

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like think about like pharma.

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It's like, oh, you take this drug.

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It does this specific thing, right?

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It's we're taking omega three as a,

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as a nutrient, as, as,

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as something that we're

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taking in our bodies and

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it's allowing the body to

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lower the inflammation in the body.

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Right.

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Which is amazing.

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Right.

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Yeah.

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It's amazing.

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And it's not really, it's really the,

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the chronic inflammation we have is,

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you know, maybe we'll get into this.

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It's not,

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not really because of omega-six

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fatty acids.

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It's from the lack of omega-three.

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The body is doing it's when you,

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get enough omega-threes and

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it doesn't make any

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difference about how much

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omega-six you got.

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It's not- Well,

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talk to people about that

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because I think there's a stigma around,

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you know, if we're talking nutrition is,

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you know, the seed oils are bad.

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These are good.

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You know,

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I've talked a lot about the

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ratios in there.

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And when you talked about

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the Eskimos and the studies

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they did on Eskimos,

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it's because their levels were so high,

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right?

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That's why they were in such good health.

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And so you've seen in your

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research that it's not

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really because the way I

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look at it is like you

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could have this much omega six,

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but then you have this much

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omega three because it's all volume,

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right?

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Because it's in the blood.

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So you've seen that it's not

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really the ratio.

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It's really just the amount

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of omega three that makes the difference.

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Is that what I heard?

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Right.

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Right.

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A ratio is you can make a

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ratio of that out of anything.

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But I don't I don't like the

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omega six omega three ratio.

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OK, because I think it's misleading.

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Number one,

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it presumes that omega six

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fatty acids are all alike.

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And there's like seven of seven omega.

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There's really only two

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fundamental omega sixes that we eat.

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In our diet,

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linoleic acid being the by far

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the predominant and then

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arachidonic acid will eat some, too.

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But we don't when we say but in the blood,

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like there's seven

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different omega six fatty

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acids that are made from them.

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And we don't,

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we imply when we just pool

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them all together as omega-six,

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we apply they all act the same way.

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All these seven different

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fatty acids all have the same function.

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And that's not true.

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We have seen time and again

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where a high level of linoleic acid,

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the primary omega-six,

Speaker:

is associated with all

Speaker:

kinds of excellent health outcomes,

Speaker:

just like a high omega-three.

Speaker:

Both omega-three and omega-six are good.

Speaker:

linoleic is good, EPA, DHA are good.

Speaker:

So this ratio is kind of good versus good.

Speaker:

I mean, that doesn't make any sense.

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So what's the point of that?

Speaker:

The idea that omega-six

Speaker:

fatty acids are

Speaker:

pro-inflammatory just has

Speaker:

no basis in evidence.

Speaker:

You look at human trials

Speaker:

where people are given

Speaker:

omega-six or linoleic acid,

Speaker:

or you look at

Speaker:

epidemiologically where you

Speaker:

look at populations,

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you look at the blood

Speaker:

levels of linoleic acid, and you look at

Speaker:

inflammatory markers in the blood.

Speaker:

There's no relationship.

Speaker:

It's not high omega-six,

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high inflammation.

Speaker:

It just isn't there.

Speaker:

And studies we've done

Speaker:

recently looking at very,

Speaker:

very large populations,

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looking at the blood

Speaker:

linoleic acid levels as a

Speaker:

predictor of health outcomes.

Speaker:

And we find that

Speaker:

consistently the people

Speaker:

that have the highest

Speaker:

linoleic acid levels are

Speaker:

the ones that live the longest,

Speaker:

have the least

Speaker:

cardiovascular disease and

Speaker:

the least diabetes.

Speaker:

So that doesn't sound like a bad thing.

Speaker:

That's a good thing.

Speaker:

So linoleic acid is a good player.

Speaker:

And this whole campaign

Speaker:

against seed oils is just

Speaker:

not based in good evidence at all.

Speaker:

It's based on the fact that

Speaker:

you can call oils processed,

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and all of a sudden,

Speaker:

because it's processed, it's bad.

Speaker:

Everything processed is bad,

Speaker:

which is stupid.

Speaker:

I mean, water's processed.

Speaker:

Give me a break.

Speaker:

I mean, everything...

Speaker:

we eat pretty much is

Speaker:

processed to some extent or another.

Speaker:

And the idea that omega

Speaker:

sixes are bad came out of

Speaker:

the the sixties and seventies.

Speaker:

And it's just been shown to be not true.

Speaker:

So what's what's the

Speaker:

I love root cause medicine, right?

Speaker:

I'm a functional medicine guy.

Speaker:

So in your opinion,

Speaker:

as you've seen in your

Speaker:

studies and in your field,

Speaker:

like this is the thing

Speaker:

you've studied for your

Speaker:

entire career pretty much, right?

Speaker:

So what is the culprit of

Speaker:

the inflammatory response then?

Speaker:

If it's not the omega-six,

Speaker:

then in your experience,

Speaker:

because I feel like that's

Speaker:

the only way we can speak

Speaker:

through these days, in your experience,

Speaker:

what would you say is the

Speaker:

key marker then for the

Speaker:

inflammatory cascade?

Speaker:

I'm not sure there's a key marker,

Speaker:

but I think probably just over nutrition,

Speaker:

being obese, being fat,

Speaker:

too much adipose tissue is

Speaker:

creating this inflammatory state.

Speaker:

And that's a big part of the problem.

Speaker:

And why are we fat?

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Well, you know,

Speaker:

how many reasons do you want?

Speaker:

We sit around in our butts all day.

Speaker:

We don't move nearly as much

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as we used to.

Speaker:

We don't exercise.

Speaker:

And we eat lots of very

Speaker:

tasty food and we put on weight.

Speaker:

And

Speaker:

That's the biggest problem

Speaker:

that's causing this chronic inflammation.

Speaker:

Adipose tissue produces

Speaker:

molecules that are pro-inflammatory.

Speaker:

I agree with that statement, too,

Speaker:

because it's

Speaker:

You know, the the visceral adipose tissue,

Speaker:

we call it hot fat.

Speaker:

Right.

Speaker:

It's all metabolically active.

Speaker:

It's got all the inflammatory markers.

Speaker:

We're moving those

Speaker:

interleukins and all that good stuff.

Speaker:

So it's a really good point

Speaker:

to make here is like kind

Speaker:

of like we don't need to

Speaker:

look at the smoking gun per se,

Speaker:

but I'm glad that you put a

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little a little.

Speaker:

scientific evidence,

Speaker:

because everything I love

Speaker:

to say is also backed by science, right?

Speaker:

You've done all these

Speaker:

studies and understand like

Speaker:

it's not the omega six is

Speaker:

similar to the fact that like, you know,

Speaker:

we're talking fats here.

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Right.

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And then for how many

Speaker:

decades did we say fat was bad for us?

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Right.

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Low fat, low carb, you know,

Speaker:

getting into these things

Speaker:

and moving into these

Speaker:

different directions.

Speaker:

And like now we're moving

Speaker:

into the direction that

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some of these fats are

Speaker:

really good for us.

Speaker:

Right.

Speaker:

Right.

Speaker:

And I'm concerned that this

Speaker:

whole anti-seed oil thing

Speaker:

is going to result in lower

Speaker:

intake of linoleic acid,

Speaker:

which primarily comes from seed oils,

Speaker:

which is going to increase

Speaker:

our risk for metabolic disease.

Speaker:

Well, I guess the question is,

Speaker:

if we get rid of all the fats,

Speaker:

because we know that we

Speaker:

don't eat enough fish in this country,

Speaker:

why it's a big,

Speaker:

a big marker for

Speaker:

supplementation and why

Speaker:

it's top three in the world,

Speaker:

or at least in the country.

Speaker:

And it's like, well,

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if we get rid of all the omegas, like,

Speaker:

well, what are we eating at that point?

Speaker:

Right.

Speaker:

So then it just perpetuates

Speaker:

the whole problem.

Speaker:

So I'm glad that you brought

Speaker:

that to light because it's

Speaker:

a really important factor

Speaker:

and something that I

Speaker:

continuously go down and learn.

Speaker:

Well, let's talk about indexing, right?

Speaker:

You said this is your cloth

Speaker:

here and talk to people

Speaker:

about how this came about.

Speaker:

And we'll definitely talk

Speaker:

about how we can do this because

Speaker:

in in my experience

Speaker:

clinically and what I've

Speaker:

heard and what I've learned

Speaker:

in my experience with omega

Speaker:

quant and indexing my

Speaker:

patients is the number

Speaker:

matters right that's right

Speaker:

if you don't know the

Speaker:

number you can't manage it right

Speaker:

But knowing the number and

Speaker:

getting it to a certain

Speaker:

level has the results that

Speaker:

you've been seeing, right?

Speaker:

Yeah, right, right.

Speaker:

So, yeah,

Speaker:

we're talking about the omega-three index,

Speaker:

which is a blood test

Speaker:

that's typically done with

Speaker:

a drop of blood on a piece of paper.

Speaker:

The blood's collected at home,

Speaker:

mailed to the laboratory,

Speaker:

then you get a report back from the lab.

Speaker:

We have is omega-quant here in Sioux Falls,

Speaker:

South Dakota.

Speaker:

uh and omega quant's been

Speaker:

around for about thirteen

Speaker:

years now we developed the

Speaker:

omega-three index test

Speaker:

twenty years ago uh in

Speaker:

early in two thousand four

Speaker:

was our first publication

Speaker:

on the omega-three index uh

Speaker:

and when I say our I mean I

Speaker:

have a colleague in germany

Speaker:

dr clemens von schacke and

Speaker:

he and I kind of cooked up

Speaker:

the idea together and then

Speaker:

have been building the case for it

Speaker:

ever since,

Speaker:

that the omega-three index is a

Speaker:

marker of risk.

Speaker:

It's not just a marker of

Speaker:

how much fish you eat, which it is that,

Speaker:

but that's not the point.

Speaker:

The point is it is a

Speaker:

biologically relevant and

Speaker:

actual risk factor.

Speaker:

So if you change the levels

Speaker:

of the omega-three,

Speaker:

you'll change your risk for disease.

Speaker:

originally proposed this

Speaker:

idea based on some studies

Speaker:

that had just been

Speaker:

published at that time in

Speaker:

the early two thousands,

Speaker:

showing that when they look at people,

Speaker:

they look across the range

Speaker:

of blood omega-three levels,

Speaker:

and you compare the people

Speaker:

with the highest omega-three levels,

Speaker:

the people with the lowest

Speaker:

omega-three levels,

Speaker:

the people with the highest

Speaker:

levels are like,

Speaker:

ninety percent less likely

Speaker:

to have a sudden cardiac arrest.

Speaker:

That was one of the studies

Speaker:

that we had learned about.

Speaker:

It was a study done at Harvard,

Speaker:

a very nice study.

Speaker:

And it was that study that

Speaker:

prompted us to say doctors

Speaker:

ought to have access to this,

Speaker:

patients ought to have access to this,

Speaker:

a marker of their omega-three level.

Speaker:

We named it the omega-three index.

Speaker:

It's the red blood cell EPA DHA content.

Speaker:

So we're not measuring plasma omega-three.

Speaker:

We're measuring omega-three,

Speaker:

which is okay in some settings.

Speaker:

For some research settings,

Speaker:

it's fine to measure plasma omega-three.

Speaker:

It correlates quite well

Speaker:

with red blood cell omega-three,

Speaker:

but red cell is more stable,

Speaker:

less noise in it.

Speaker:

Kind of like hemoglobin

Speaker:

A-one-C is a better

Speaker:

long-term marker of

Speaker:

diabetes status than is the

Speaker:

blood glucose level.

Speaker:

So it's the same idea.

Speaker:

So the omega-three index, EPA,

Speaker:

DHA as a percent of the

Speaker:

total fatty acids in a red cell membrane.

Speaker:

That percent is roughly

Speaker:

ranges from a low of two

Speaker:

percent to maybe up to ten,

Speaker:

twelve percent.

Speaker:

So that's the range.

Speaker:

Most Americans are in that

Speaker:

five-ish percent area.

Speaker:

Vegans are down there around

Speaker:

three and a half percent, which is low.

Speaker:

People in Japan or people in

Speaker:

Korea who eat a lot more

Speaker:

omega-three than we do,

Speaker:

eat a lot more fish as part

Speaker:

of their culture.

Speaker:

They're having an

Speaker:

omega-three index of seven, eight, nine,

Speaker:

ten percent in that area.

Speaker:

We think eight percent and

Speaker:

above is really kind of the,

Speaker:

use the word optimal.

Speaker:

We think that's an optimal place to be.

Speaker:

And getting up there is not,

Speaker:

doesn't take huge amounts

Speaker:

of fish or huge amounts of supplements.

Speaker:

It's fairly doable.

Speaker:

But that's the omega-three index test,

Speaker:

and we've been studying it

Speaker:

and its relationship with

Speaker:

disease outcome for a long time now.

Speaker:

And like you said, higher levels are good.

Speaker:

Let me repeat what you said, though,

Speaker:

is you saw that when you

Speaker:

get the omega-three levels

Speaker:

at those optimal ranges of

Speaker:

where people ate a lot of fish,

Speaker:

eight to twelve percent,

Speaker:

you're seeing ninety percent

Speaker:

decrease in sudden cardiovascular events.

Speaker:

Yeah.

Speaker:

And that needs to be

Speaker:

explained because that's what's called a,

Speaker:

it's an observational study

Speaker:

and it's a kind of a case control study.

Speaker:

We've, and that's for people who,

Speaker:

nobody's taking supplements

Speaker:

or fish oil supplements in these studies.

Speaker:

This is just,

Speaker:

some people have high levels

Speaker:

because they eat a lot of fish.

Speaker:

Some people have low levels

Speaker:

because they don't.

Speaker:

The people who chronically

Speaker:

eat higher amounts of

Speaker:

omega-three have higher

Speaker:

omega-three index in their blood.

Speaker:

And those people are the

Speaker:

ones that are lower risk

Speaker:

for sudden death.

Speaker:

That was the study anyway, back in the,

Speaker:

in two thousand two that

Speaker:

came out that prompted the

Speaker:

development of the omega-three index.

Speaker:

At this point,

Speaker:

I can't say that people that

Speaker:

have the highest

Speaker:

omega-threes are ninety

Speaker:

percent less likely to have

Speaker:

sudden cardiac death now.

Speaker:

I think evidence has accumulated.

Speaker:

It's maybe thirty or forty percent,

Speaker:

but that's huge.

Speaker:

It's a nutrient.

Speaker:

Dr. Justin Marchegiani Right.

Speaker:

Exactly.

Speaker:

What I would tell people is

Speaker:

I've been on stage and I say,

Speaker:

imagine a drug like that

Speaker:

could reduce cardiovascular disease,

Speaker:

like sudden cardiovascular

Speaker:

risk by thirty five percent.

Speaker:

Like no drug can say that.

Speaker:

Right.

Speaker:

But omega three has been

Speaker:

shown like it's a correlation.

Speaker:

Right.

Speaker:

We're not saying you take omega three.

Speaker:

You're going to definitely have this.

Speaker:

It's not a cause and effect thing,

Speaker:

but it's an overall thing.

Speaker:

And I just say the omega-three indexing,

Speaker:

the easiest way I've said

Speaker:

it to my patients and

Speaker:

pharmacists when I teach

Speaker:

them to use this in their pharmacies,

Speaker:

because it's a point of care test.

Speaker:

All we need is a CLIA waiver

Speaker:

to do it in the store.

Speaker:

You can give it to the patient.

Speaker:

They can do it.

Speaker:

It's really simple.

Speaker:

It's a finger stick, dried blood spot,

Speaker:

right?

Speaker:

Right.

Speaker:

And...

Speaker:

It's the best test your

Speaker:

doctor will never tell you to get, right?

Speaker:

It's one of those tests

Speaker:

where if I could help someone,

Speaker:

because this is what we're talking about,

Speaker:

high impact, low cost.

Speaker:

If I could help someone at

Speaker:

this level of impact,

Speaker:

And, you know,

Speaker:

an omega three index is less

Speaker:

than a hundred dollars.

Speaker:

Right.

Speaker:

And we can move it.

Speaker:

We can move it in a way

Speaker:

that's accessible because there's,

Speaker:

and this is why I love

Speaker:

bringing this into the pharmacy practice.

Speaker:

It's like,

Speaker:

what if we could do a one C

Speaker:

omega three and a vitamin D on everybody?

Speaker:

we would be, we would,

Speaker:

and then we optimize the omega-three,

Speaker:

we optimize the vitamin D,

Speaker:

we look at their metabolic

Speaker:

health in three simple ways.

Speaker:

This is why I created Rx to

Speaker:

Wellness and the Wellness

Speaker:

Made Simple stuff that

Speaker:

we're doing and launching

Speaker:

is because those three

Speaker:

simple labs and three simple supplements,

Speaker:

because I add magnesium in there,

Speaker:

can do a whole lot for health rather than

Speaker:

fifteen hundred dollar a

Speaker:

month medications and so I

Speaker:

I love simple bill and I

Speaker:

love getting high impact

Speaker:

and that's why I've been I

Speaker:

love this test and I love

Speaker:

how simple we can do this

Speaker:

because you test right you

Speaker:

see where your levels are

Speaker:

and then you're the we've

Speaker:

seen the the labs because

Speaker:

we've used them it's like

Speaker:

you need to eat this much

Speaker:

fish or you need to take

Speaker:

this many supplements

Speaker:

To get you to the eight to twelve percent.

Speaker:

So it's a really simple way

Speaker:

to get you high impact,

Speaker:

high results and little to no effort.

Speaker:

Right.

Speaker:

Yeah, that's right.

Speaker:

That's right.

Speaker:

And certainly safe and it's

Speaker:

cheap and doesn't interact with any drug.

Speaker:

That's a problem.

Speaker:

So it's it's a great way to go.

Speaker:

Well, in that that's the,

Speaker:

I always get the patients

Speaker:

that say this or that, like,

Speaker:

so what I'm hearing is also like,

Speaker:

if someone's on blood thinners,

Speaker:

they can still take omega three.

Speaker:

Right.

Speaker:

Right.

Speaker:

Right.

Speaker:

So there's really no

Speaker:

contraindication here.

Speaker:

Cause it's coming from

Speaker:

something that's got high impact,

Speaker:

low inflammatory cascade.

Speaker:

And we can, we can work the,

Speaker:

we can work from this top end downstream,

Speaker:

like approach.

Speaker:

which again, high impact, low dollar.

Speaker:

What better is that, right?

Speaker:

How can it get any better than that?

Speaker:

Right, exactly, exactly.

Speaker:

So how do people,

Speaker:

so OmegaQuant is the one

Speaker:

I've been using for years.

Speaker:

That's the lab that you've co-founded.

Speaker:

No, I actually found it by myself.

Speaker:

That was not co-founded.

Speaker:

Oh, that one.

Speaker:

I'm sorry.

Speaker:

That one was you.

Speaker:

Yeah,

Speaker:

that was totally the founder of... It

Speaker:

was co-founded, right.

Speaker:

We have patients,

Speaker:

but we also... I teach

Speaker:

pharmacists wellness.

Speaker:

I teach practitioners wellness.

Speaker:

in the the allopathic world

Speaker:

because this is one of the

Speaker:

key members here is like

Speaker:

you can use this in your

Speaker:

practices primary care in

Speaker:

your pharmacy settings so

Speaker:

we're going to set up links

Speaker:

for practitioners to set up

Speaker:

and get this lab into their

Speaker:

spaces really easily and we

Speaker:

also have patients that can

Speaker:

buy this directly if

Speaker:

they're wanting to do their own

Speaker:

you know, their own test here.

Speaker:

It's, it's not complicated.

Speaker:

It's not complex, right?

Speaker:

No, very easy.

Speaker:

So we're thinking easy, simple.

Speaker:

Um, and you know, it's,

Speaker:

it's a finger stick away.

Speaker:

And then also you do, um,

Speaker:

we have it for pets too, right?

Speaker:

For dogs, for dogs.

Speaker:

Yeah.

Speaker:

Right.

Speaker:

So my wife is, I'm coaxing her.

Speaker:

She just graduated one of

Speaker:

the first classes of

Speaker:

holistic pet health coaching.

Speaker:

And I said,

Speaker:

you got to put a mega three in

Speaker:

there for your dog, because guess what?

Speaker:

We love our dogs probably

Speaker:

more than we love ourselves.

Speaker:

You know,

Speaker:

we want them to live around longer.

Speaker:

And so if they're not in their diet either,

Speaker:

it's a really useful test.

Speaker:

So you can also test your animals too.

Speaker:

That's right.

Speaker:

And you can also test pregnant women.

Speaker:

Pregnant women can test

Speaker:

themselves because it's

Speaker:

important that they have a

Speaker:

high DHA level while

Speaker:

they're pregnant to help their baby.

Speaker:

And also it's been shown

Speaker:

that higher omega-three

Speaker:

levels in pregnancy have

Speaker:

been shown to reduce risk

Speaker:

for preterm birth.

Speaker:

And pregnancy extends gestation a few days,

Speaker:

which is an important writ large.

Speaker:

The longer you can keep the baby inside,

Speaker:

the healthier they are, to a point,

Speaker:

obviously.

Speaker:

So that's a good test.

Speaker:

And we also have a milk lactation test.

Speaker:

Mom can put a drop of her milk on a card,

Speaker:

just like the blood,

Speaker:

and we can measure the DHA

Speaker:

content of that.

Speaker:

advise her whether she needs

Speaker:

to take more omega-three or not.

Speaker:

That's perfect.

Speaker:

These are like beautiful, easy,

Speaker:

like we can talk really high level.

Speaker:

It reduces inflammation,

Speaker:

does this with cardiovascular system.

Speaker:

But when we're getting down

Speaker:

to like the details, it's like,

Speaker:

can we help these specific things, right?

Speaker:

Keeping the gestation super important,

Speaker:

healthy babies, good brain health.

Speaker:

I've used omega-threes in so

Speaker:

many different, like we've used it for

Speaker:

traumatic brain injuries.

Speaker:

Like there's so many

Speaker:

different things we can use

Speaker:

the omega-threes for that

Speaker:

are going to help with that inflammation.

Speaker:

But what we're talking about here is very,

Speaker:

it's optimization.

Speaker:

That's the hugest part that

Speaker:

I think is so important

Speaker:

here is instead of just

Speaker:

recommending a supplementation,

Speaker:

we're recommending that

Speaker:

we're looking at it

Speaker:

optimizing it.

Speaker:

I just call it test, treat, test protocol,

Speaker:

right?

Speaker:

You test, you get the levels, you optimize,

Speaker:

and then you retest to see

Speaker:

where you're at.

Speaker:

Simple, easy, and high impact.

Speaker:

Right.

Speaker:

Evidence-based medicine, right?

Speaker:

Evidence-based healthcare.

Speaker:

Back by science, evidence-based, right?

Speaker:

This is evidence-based well care, I think,

Speaker:

because we're using this as

Speaker:

a proactive approach to

Speaker:

modifying someone's health

Speaker:

and making it really simple, right?

Speaker:

For me,

Speaker:

I've gone very complex in my career

Speaker:

and in my life about all

Speaker:

these high-level protocols

Speaker:

and all these things we can be doing.

Speaker:

And I've moved back into

Speaker:

this simple space because

Speaker:

you know,

Speaker:

wellness and well care made simple.

Speaker:

I put omega-three and

Speaker:

indexing at the cornerstone

Speaker:

of that because of its high impact,

Speaker:

right?

Speaker:

That's what we're talking

Speaker:

about here is where it's

Speaker:

simple and it's got a high

Speaker:

level of impact rather than

Speaker:

getting in like the eighty twenty rule.

Speaker:

If we could do this eighty

Speaker:

percent of the time,

Speaker:

we don't have to worry

Speaker:

about the little stuff.

Speaker:

Right, right, right.

Speaker:

Handle the big problems first.

Speaker:

And that's the big problem.

Speaker:

Low omega-three.

Speaker:

And in our Westworld brains,

Speaker:

you can do this pretty quickly.

Speaker:

You can do it pretty easily.

Speaker:

Have you,

Speaker:

and using quality supplementation, right?

Speaker:

We're talking omega-three supplements.

Speaker:

versus fish oil.

Speaker:

We talk a lot about that, right?

Speaker:

So there's some labeling

Speaker:

things we want to talk to

Speaker:

our patients about the omega-three EPA,

Speaker:

DHA values that are in the

Speaker:

capsule and getting it from

Speaker:

quality sources that are

Speaker:

purifying it and moving out

Speaker:

all the toxicities because

Speaker:

there's a lot of toxicities

Speaker:

and things like that, right?

Speaker:

Well, I mean, in fish oils,

Speaker:

omega-three products, there's very little

Speaker:

There's no mercury, for one thing.

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That's all taken out just as a matter of,

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because mercury is water

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soluble and fats are lipid soluble,

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when they're separating at the first pass,

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when they're taking the

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fish they collect and

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cooking them down and

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separating the oil from the fish meal,

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any mercury that's there,

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and there's very little

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there because these are

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typically anchovies or sardines,

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really small fish.

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Any minerals that are there

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are going to go with the water layer,

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not with the oil layer.

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So it starts right away.

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You're not going to have any

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of the minerals or the

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metals that people are concerned about.

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And then just the very

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process of cleaning up a

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fish oil to where it's even

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tolerable taste-wise.

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There's a lot of steps.

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Even the simplest or maybe

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the cheapest fish oils

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go through quite a few steps to get clean.

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Yeah.

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You can get cleaner and

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cleaner and cleaner and pay

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more and more and more and more.

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The higher the concentration of omega-free,

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typically the cleaner it is in a way.

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Yeah.

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They've distilled it down into the parts,

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right?

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EPA, DHA.

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I always gone in this space

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of like best quality on the

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planet for the price,

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like moving those two together.

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Cause you can go high end spectrum,

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you know,

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And then you could go really low quality,

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but then to get to eight to

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twelve percent,

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it's a lot more pills a day.

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Yeah.

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So we get no burden.

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Right.

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So it's kind of like in that middle.

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Like,

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where do we get into the middle zone?

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So test, treat, test,

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and go on the website.

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We're going to send the links.

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So providers, right?

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If you're listening and you

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want to put this into your practice,

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we're going to give you

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avenues there as well.

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This is super important because it is,

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it's very accessible too.

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This is not something that's difficult to,

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you don't have to go to a

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lab quest and get blood draw.

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Like it's literally a drop of blood,

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send it out.

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And your provider can help

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you manage this.

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I've used my my friends and colleagues.

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We didn't even talk about eye health.

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Like there's so many

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different ways that we can

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improve the status.

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Of the omega three by testing,

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seeing it and then optimizing it,

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which is super great.

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Right.

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And it looks like this eight

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percent target is pretty

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much optimal for every

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disease condition we've looked at so far.

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So you don't have to hit one

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target for one thing and

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one target for another thing.

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And it just get to eight

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percent and then go worry

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about something else.

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That's so it can't get any

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simpler than that, right?

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Test,

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take its supplements or eat this much

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fish and then retest.

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If you're at eight percent,

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stay with where you're at

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and you're good.

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Right.

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You got to keep doing it.

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I mean,

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that's the important thing is once

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you've reached eight

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percent and you decide, OK, I'm there,

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I'm going to stop taking my omega three.

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Sure.

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Fall right back.

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It's a factor, right?

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It's in there all the time.

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I love that.

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So in your experience, as we're closing up,

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this has been such a very

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valuable conversation.

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So thank you because I think

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it's just so important to,

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to reiterate here is like we got,

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we can get so complex with

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our health routines and the

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things we need to do.

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And this is very simple.

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This is super simple.

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So in your experience, this is forty,

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fifty years of really

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diving in deep on this one.

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This isn't like a reiteration.

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Like we're still talking

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about the same thing.

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Omega three.

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Right.

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If you had to give someone like one.

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What was if they had to

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think about one thing they

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could do right now, what would it be?

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Well, obviously,

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test your omega three level.

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If it's too low,

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increase your omega three intake.

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and retest to make sure

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you're at eight percent.

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I mean, that's three things.

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But it's one thing.

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It's optimizing your omega

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three index status.

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Couldn't say it any better than that,

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because.

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I've been in nutrition for a

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long time and teaching

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wellness is like when you

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optimize in this again,

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we've gone all the way to

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genomics and longevity and

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all these things people are doing,

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and it's like

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You guys, you heard it from the OG here.

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You heard it from the original guy.

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He's telling you this is the

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simplistic way of doing it,

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but simple doesn't have to be difficult.

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It can be really impactful.

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Right, right.

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Exactly.

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Genetic tests, you can't really change,

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but this you can change.

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And, and, and,

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and what we can do is what we,

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we really need to focus on

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in this day and age and,

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and making it simple and

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easy is super important.

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Well, we're gonna send the links.

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We're gonna have everybody to,

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to hopefully the listeners

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will listen and,

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and do these simple things because let's,

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let's, let's talk simple, right?

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Simple.

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So easy.

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Right.

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Well, Bill,

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I really appreciate you coming on today.

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I really,

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really think this is going to be

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an amazing,

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impactful thing that we can do.

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Like I said, you know,

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this is part of our mission

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to to help make medications unnecessary.

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And this is a good one step for that.

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Thank you.

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Thank you, Josh.

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Good to be on with you.

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Appreciate you guys.

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Until then, everybody stay well.

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