Suzanne is joined by Dr. Paul Winner, the Senior Director of the Premiere Research Institute and Attending Neurologist at Palm Beach Neurology in West Palm Beach, Florida.
Dr. Winner emphasizes, “Memory loss is not normal in aging. That is very clear to us now as we study this. When we forget something in our 20s or 30s, we don't even think twice about it. When we get in our 50s, 60s, 70s and we forget something, we wonder: am I getting Alzheimer's? First of all, it takes a long time to get Alzheimer's. The initial pathology is the depositing of something called A beta 42, a toxic protein called an amyloid. It's 15 to 22 years from the time that metabolic problems starts till we make the clinical diagnosis using clinical signs of Alzheimer's disease. So a lot of things are happening in the brain. People are normal for a long time while this biology is happening underneath with regard to the deposition of amyloid. And then there's another thing that happens. A deposition of another protein happens. The amyloid starts to cause trouble with the synapses, the communications in the brain. That's when you're starting to see the short-term memory issues in something called the temporal lobe region. And then you get, essentially, problems with the deposition of another protein called phosphorylated tau nerve cells are starting to die, and now you're getting more prominent symptoms. All of this takes years to decades happen.
Pay attention to an individual, comparing how they've been all their life, and if something there seems to be memory loss in aging, that's the time for concern. Dr. Winner explains, “An example I had recently: a couple came in and the husband noticed that when she's cooking, she's forgetting to put certain ingredients in, and she's a fantastic cook according to her husband. He's noticed over the past year or so that things aren't made right. He actually sees her shying away from cooking certain things. So we start to see people start to pull back. They know something's wrong, so so they say, let's go out to dinner more. I'm not gonna make that. I don't like making that anymore because it's complicated, or socially, they're finding it's hard to put a word in a sentence. They just can't get the right word in the sentence. And now they feel a little funny if they're going to go out socially and in a conversation, they can't keep the conversation going. They lose track and they realize something's wrong. I don't want to show this to other people, and they start essentially withdrawing, and that makes the situation worse. Human beings need to be interactive with other human beings.
Dr. Winner has participated as Investigator and Principal Investigator in numerous clinical studies.
Learn more about the Athira Pharma Alzheimer's LIFT-AD research study, Interested in learning more? Contact Premiere Research Institute at (561) 296-3838, contact Dr Winner at (561) 851-9400 or learn more about him here. This podcast is courtesy of Athira Pharma.
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