Lee Goldberg is known for his bestselling novels Lost Hills and True Fiction and his work on a wide variety of TV crime series, including Diagnosis: Murder, A Nero Wolfe Mystery, Hunter, Spenser: For Hire, Martial Law, She-Wolf of London, SeaQuest, 1-800-Missing, The Glades and Monk.

In 2007, Goldberg wrote and produced the pilot for a German television program, Fast Track: No Limits which aired on television in some countries and was released a theatrical film in others.

In 2010, he wrote and directed the short film Remaindered, based on his short story for Ellery Queen's Mystery Magazine, on location in Kentucky. He wrote and directed the sequel, Bumsicle, in 2012.

In 2019, he co-wrote and co-created with Robin Bernheim the Hallmark Movies & Mysteries telefilm series Mystery 101 starring Jill Wagner and Kristofer Polaha.

In April 2021, Constantin Films announced that they will be producing a feature film version his novel The Walk based on his screenplay adaptation.

In March 2022, production began on Fast Charlie, a feature film adaptation Goldberg wrote based on the novel Gun Monkeys by Victor Gischler, directed by Phillip Noyce and starring Pierce Brosnan.