Today, we explore a groundbreaking research paper published in JCI Insight by Ma and colleagues in June 2020, titled “Platelet factor 4 is a biomarker for lymphatic-promoted disorders.” The study, which included contributions from Dr. Stanley Rockson at Stanford University and Dr. Guillermo Oliver at Northwestern, aimed to identify a biomarker for lymphatic dysfunction and improve the diagnosis of lipedema, further confirming that lipedema is a lymphatic disorder.