160: Premature Ovarian Insufficiency

Dr. Jane Levesque: 00:00:00

We're seeing this mitochondrial DNA damage be passed over time. We are seeing more and more health issues in younger and younger populations. And now we're at a point where infertility is a really big struggle because essentially there's too much mitochondrial DNA that has been passed down. And what I always say, not to sound discouraging, is like, hey, we don't have the choice of what has been inherited to us, but we absolutely have a choice of what we can pass down. And the cases that I worked with premature ovarian insufficient deficiencies, where I'm never surprised why this woman sitting in front of me doesn't have good ovarian function. Pregnancy is a natural process. So if it's not happening or if it's not sticking, something is missing. After having a family member go through infertility and experiencing a miscarriage myself, I realized how little support and education women have around infertility. I want to Change that. I'm Dr. Jane Levesque. I'm a naturopathic doctor and a natural fertility expert. Tune in every Tuesday at 9am for insightful case studies, expert interviews, and practical tips on how you can optimize fertility naturally. If you've been struggling with infertility, pregnancy loss, women's health issues, or you just want to be proactive and prepare yourself for the next big chapter in your life, this show is for you. All right, ladies, today I want to talk to you about premature ovarian insufficiency. This is a topic that I got to speak on when I went to the Eco conference, the Exponential Clinical Outcomes conference hosted by Cellcor.

Every year they over: 1800

But in reality, they've actually masked a serious issue and, and potentially made it much worse. So by the time you are ready to have a baby and now it's, you're 35 and you have no idea what your cycle is supposed to be like, we're seeing a lot of issues. And so my hope is that we bring some awareness and education around this so we can start to protect our ovarian function. Because without ovaries, ladies, we do not have the next generation. Our ovaries are hosting their place that are holding our follicles. And the follicle is the only cell in the body that has the capacity, the oocyte, and is the only cell in the body that has the capacity to become a human life. And so I think we should be protecting our ovaries a lot more than we are, and we should stop messing around with ovarian function and birth control and all these hormones and even ivf. I see so many women go into something that feels so against what they believe, and they're just kind of pushing themselves to do it. And whether it's because they feel pressure from their family members, from their husband, or just themselves, they, you know, are ready to, quote, unquote, give up, and this is the only thing that they feel like is going to work. My hope is that we can reconnect you to your ovaries, teach you how to protect them, how to revitalize their function so then we can still have biological children. And so there's a lot to unpack here. Let me kind of start off by, you know, the common theory right now is that obviously we as women are born with all of our eggs. This is what we know have about 6 to 7 million eggs, 20 to 40 weeks gestation. So when you're in your mom's belly, you have 6 to 7 million eggs. @ birth, that number drops to a million follicles. So there's a huge atresia, there's a huge die off. We don't really know why that is. But in, you know, there's high demands on nutrients, there's high demands on methylation, there's high demand on mitochondrial function during that gestation period. That potentially has something to do with the die off of all the follicles. And then you Know, at about puberty, the woman is going to be at 500 to 600,000 follicles. And then after that, with every menstrual cycle, you're going to lose 30 to 40 follicles per cycle. So you're getting a recruitment of follicles, and then only one, maybe two are chosen. Again, depending if it's a singlet or, you know, a twins or triplets. But essentially, most commonly, it's just going to be one follicle that's chosen. That's where all the energy is going to go. The mitochondria is going to do its thing. It's going to multiply and replicate and give all this energy to the oocyte to essentially have the opportunity to be fertilized and then of course, become an embryo and then a fetus. So that's kind of your general rundown of what happens. We do have, you know, kind of most recent research and science. We do have some ovarian rejuvenation therapies that are coming out. And whether that's plasma rich therapy or stem cell therapy, even ovarian transplantation, like there' some things that we are doing to see if we can produce new follicles. And even when the woman goes through menopause, we know that there's still follicles within that ovary that never got recruited. We don't know why they didn't get recruited, but we do know that there's still follicles that are left over. And so these PRP and stem cell therapy and even ovarian transplantation, they're all designed to see if we can basically wake up and wake up or use some of these follicles that never got recruited or just to essentially increase blood flow to the area. So then that follicle has what it needs. It needs blood flow. If there's no blood flow or if there's no nutrients within that blood, then the follicle can't get what it needs in order to go through this huge transformation. Right. The only cell in the body that has the capacity to transform into human life. Just to think about from the physical standpoint of what that cell has to be able to do and the function within that cell and how important it is for those n the methylation and the blood flow to be there. And then I will touch upon the energetics of it and the spiritual component of ovarian function and what I'm seeing in practice and just in general. So this is kind of the general. You know, we are born with our Eggs, we lose them. And so what is happening in premature ovarian insufficiency is essentially a woman is losing. She either was born with less eggs than the average person, she's losing the eggs too quickly. So that atresia is happen fast. It's not 30 or 40, it's maybe 100 to 200 to 500 follicles a month that are being lost, or the connection between the brain and the ovaries isn't there. And so essentially the follicle is just not responding to the brain signals because ovulation does start in the brain. So for any of those reasons, you can be essentially diagnosed with premature ovarian insufficiency. You and I will go ahead and say, like, if you have diminished ovarian reserve, it's. I don't want to say it is exactly the same thing, but the quality and the quantity of the egg is down. And so premature ovarian insufficiency is just that you don't have those eggs there. Diminished ovarian reserve, you don't really have those eggs there. But if you're older, if you're over 35, they just tend to say it's diminished ovarian reserve versus when you're younger, under 35, they tend to just say you have premature ovarian insufficiency. But to me, it's essentially, it's the same thing. We don. The eggs that we need, we don't know the quality of them. They're not responding as much.

You know, all the same, the same story. So when we are approaching this, the first thing to understand, I do think that premature ovarian insufficiency is a genetic disorder because the quality of the egg is highly dependent on the health of the mother and the health of the grandmother when she was pregnant with your mom, and then the health of your mom when she was pregnant with you. Because if you think about a B and when the ovaries are developed for the baby, it's the grandma is pregnant and she is. The baby has the ovaries, and the ovaries are hosting the cells that will then become her grandchild. So there is a trigeneration effect, and there's even studies showing the quad generational effect, because, let's be honest, we pass on our genes and we pass on our nutrients and our energy and our vitality, and we also pass on our tox load. And so it is. There's so much research about this coming out now, whether it's heavy metals or pesticides like glyphosate atrazine or mold, any industrial toxins, your phalates, your plastics, your BPAs, like we're just surrounded by this soup of toxins, if you will, that it absolutely is passed down to the next generation. And it is essentially becoming part of our cells. Like we see microplastics that is literally in brain cells, in the ovaries, in the testes. It's everywhere. And it is absolutely impacting the function of our ovaries, of the men's testes, and just of our ability to essentially reproduce. So we have a little bit of work to do. And by a little bit, I mean a lot. And I will talk about the mitochondria that gets passed on. Okay? So the function of the mitochondria is probably the single most important thing when it comes down to the function of the egg. So if you're working with a pract and they're never talking about mitochondrial function to you, or it's very superficial, just take some CoQ10 and take these vitamins, and this is what's going to support your mitochondria. They're missing a very critical component. Mitochondria is what determines the quality of the egg. And so if there is not enough mitochondria, it is considered an aged oocyte. It is an old egg that's not. Doesn't have the capacity to do what it needs to do in order to become a human life. And so if there is a diminished amount of mitochondri, the diminished amount of mitochondria, or that mitochondrial DNA is damaged, essentially the egg is just doesn't have the energy to do what it's supposed to do. And we consider it a bad quality egg. So mitochondria is the core of egg function. It is how we. Where the hormones are made. So your estrogen, your progesterone, your testosterone, but also your cortisol, which is coming from the adrenal glands. It is how our body makes energy. It is how our body makes energy to then detoxify, to repair itself, all of that jazz. And it's a very high concentration in the egg, especially as that follicle is growing and maturing. So it starts out with not a lot of mitochondria. And as it grows and matures over time, over time, over that monthly cycle. And I'll talk about from the beginning maturation in a second. But like, let's just take one menstrual cycle at a time so that one month as it grows and matures, and it gets more blood flow. And there's the beautiful granulosa in the theca cells that are going to support the maturation of the follicle. And they're the ones that are going to help to produce the estrogen and the progesterone and the testosterone. That's what will determine the quality of the egg and the capacity of it to repair itself. And so maybe you know this, maybe you don't, but you will know that now 100% of the mitochondrial DNA is passed down from the mother. And so I have baby girls, I have passed down. And if you have kids you like, as a woman, you have passed down your mitochondrial DNA. Your mom passed her mitochondrial DNA onto you. So we've kind of understand how this damage has accumulated over time. But 100% of your mitochondrial DNA is inherited from your mother. And so if we have little tweaks within the little damages within the mitochondrial DNA, it doesn't tend to result in fertility issues. But what is happening is that we are accumulating this mitochondrial damage over time. And this is the trigenerational and the quad generational effect. You're accumulating this damage over time. And then all of a sudden, we're seeing the fertility rates, infertility rates skyrocket. Because now you have issues with the DNA of the mitochondrial DNA that will allow the mitochondria to replicate and to fix itself. So then only the best could be passed on. And then the more the healthier the mitochondria, the healthier the mitochondrial DNA is, and vice versa. Like, those two things are very interchangeable, where the healthier the mitochondri mitochondrial DNA, the more essentially the cell has the capacity to repair itself and to only choose the best cells to move forward. This is like a natural phenomenon that happens within the cell. Mitochondrial bottleneck, it's called. Before it goes on to replicate, the body kind of like shrinks everything down, picks the best guys, picks the best mitochondria, and then it amplifies itself.

And that's when you know, by the time it gets to be a mature egg, a mature follicle, that one is growing to 20, 25, 28 millimeters. It is filled with mitochondria, and it is the only cell in the body with the highest amount of mitochondria. Okay, because of the capacity of the transformation, I hope I have, like, drilled that down. There's so much transformation that has to happen. Remember, it's a cell that accepts a sperm and then becomes into a human. Like, it's wild, it's Wild what the body is capable of doing. But unfortunately, because we're seeing this mitochondrial DNA damage be passed over time, we are seeing more and more health issues in younger and younger populations. And now we're at a point where infertility is a really big struggle because essentially there's too much mitochondrial DNA that has been passed down. And what I always say, not to sound discouraging, is like, hey, we don't have the choice of what has been inherited to us, but we absolutely have a choice of what we can pass down. And the cases that I worked with, premature ovarian insufficiencies, where I'm never surprised why this woman sitting in front of me doesn't have good ovarian function. She's had a history of high toxic load. She's had a history of a lot of inflammation. And whether that's coming from the toxic load or other chronic infections or very high levels of stress. And that stress could be when she was a child and she was constantly sick on antibiotics. Antibiotics and just poor quality of life, if you will, from a sense of, like, not properly nourished on medication, under, slept, moved a lot, bullied a lot. Whatever it is, it's like the body just accumulates that stress, let alone what happened during pregnancy. So many women will talk to me and say, oh, yeah, I think my mom had a fine pregnancy. And I'm like, just ask her. And then they ask. And I was like, oh, yeah, she did develop preeclampsia, or she did have a very stressful time with my father. At time my father actually tried to attack her, or my dad was an alcoholic. And all of a sudden you're like, huh? Is there a chance that you actually don't know what it's like not to be stressed? Is there a chance that your system has just been stressed from the moment that you've been born? And it's like, yeah, for some of these women, that's the case. So if I look at the whole picture, I'm never surprised why the woman sitting in front of me why her ovaries have decided to shut down. Because it wasn't one hit or two hits or three hits. It's been multiple hits time, some big around the zero to seven, something around puberty. So puberty, remember, is the time where the egg, where the brain is connecting to the ovaries. And so if there's a lot of stress during that time, essentially the woman's ability to connect to the ovaries is diminished. And so then one of the reasons that you develop premature ovarian insufficiency is the lack of response from the ovaries to the brain. The brain is sending the message to the ovaries, but the ovaries are not doing anything with it. It so, and then there's usually in the 20s, I want to know what the woman did, how did she treat herself, what were the things that were going on? And then when did she actually get diagnosed? What symptoms did she have? Was she on birth control? You know, I had someone who was on birth control for like the patch or whatever, the injectables where she just didn't get a period for a couple of years. And in her gut she was like, I don't know if this is that good for me. But then it was so easy not to have a period. And what I want to encourage you, and I'll talk about the spiritual connection in a second, is listen to that gut.

Because a lot of the times you've got tells you that something is wrong, but you don't have enough confidence to say, oh, I trust my gut and I'm going to do the thing that's hard versus that's easy. And the hard thing is to say, you know what, I'm not going to be on this birth control. I am going to go ahead and track my cycle and maybe I'm going to abstain from sex for a while so I don't worry about getting pregnant, but I'm going to figure out my cycle and stay on top of that instead of deal with it later. The dealing with it later is just unfortunately, I think, is not, I don't think anybody should do that. But like, we're just in a state with fertility and health that you don't, if you continue to push it off later and later. Later doesn't actually come as late as you think. I see men who have, they're in their mid-20s and they'll have levels of triglycerides and just cholesterol and blood sugar dysregulation of that of a 50 year old. And so you think your heart attack maybe will come when you're 60 where it's like, no, man, you keep going this way, in the next five years you'll have a heart attack. So I think it's the same for women where women just don't realize. One of my patients that I'm thinking about, she had night sweats, she had difficulty sleeping and hard time putting on weight and she's had a high toxic load before. And I'm like, you've had night sweats for two years, and people told you it's nothing. It's like, that's literally menopause. Like, you're literally in menopause, and people were just brushing her off. So I want you to be aware of all the symptoms, and I want you to learn how to protect your ovarian function. And I realize this is probably another podcast because I can talk about this for forever, but point being is, when I look at the whole history, I'm never surprised that the woman sitting in front of me is struggling with premature ovarian insufficiency or diminished ovarian reserve. And so if I bring the energetic component here and I just kind of switch gears, if the ovaries is, you know, the place that produces hormones and has this insane capacity for transformation and creative power, I think about, what does that mean energetically? What is it? How do you, as a woman feel when your ovaries are fully functioning versus when they're stuck and, you know, you can't ovulate because you have PCOS or something else that's preventing the body from being able to ovulate? How do you, as a woman, experience the world when your ovaries are not functioning to their fullest or, you know, when you're in menopause, versus in your early 20s? And I realized, like, I kind of used to pose this question of, like, what is it? What are your ovaries doing for you? I think that's hard to answer for somebody who's never had good ovarian function. And so what I encourage you to think about instead is if our ovaries have this immense capacity to transform into, create, and it is the thing that allows us to become a mother, then what is the creative energy that we have within ourselves and are we able to fully express it? Is there a place where we're suppressing that energy, and maybe we don't even know where that is yet? It is also our connection to our past generations and our ancestors. And so this is why a lot of the time, infertility is very triggering, because it brings up a lot of trauma for us, and it can cause trauma, too. But I do find it brings up a lot of trauma from just past generations because we are connected through our ovaries. And remember that babies, the egg, the future baby. When my grandma was pregnant with my mom, she was holding the eggs that became myself and my sister, which is just crazy to think about. And so there's a really big connection to our ancestors.

There is a big Connection to the source. We are creators, ladies. We have the capacity to make human beings. It's crazy. I think about that all the time. And so the ovaries, to me, are this really vital organ that unfortunately, I think is really misunderstood. And maybe we place a lot of expectation that our body's just going to be able to do what it's designed to do, because the ovaries are designed, designed to do that. We as women are designed to have babies, but we are not designed to live the way that we have been living for the last 50 years. You know, and there's some big, drastic changes that we've noticed, especially in the last 10 years. And this accumulation of toxins and the screen time and the lack of movement and the poor quality food and all the toxins in our food and in our water and in our dishwashers and in our clothing and everywhere. And it's overwhelming. But essentially, unless we open up our eyes and say, hey, I need to learn how to protect my ovaries, because these are vital organs and they're the first ones to age, Our ovaries are one of the first organs to age and they're the most sensitive to oxidative damage. And so when I meet a woman who's highly inflamed and has a lot of toxic burden and high stress, I know that her ovaries are not doing what they can be doing, what they should be doing, because the body has other priorities. It is dealing with the immune system dysregulation and with the inflammation and the blood sugar and the stress and all of that. And so I encourage you, ladies, if you are struggling with diminished ovarian reserved or premature ovarian insufficiency, is to ask some of those deeper questions of how far back does this really go? What have I really inherited? And giving yourself an opportunity to process that. I think I meet so many women who are just like, well, it doesn't matter, I can't control it. So whatever, it's like you can't control it, but you also haven't fully processed it yet. If there is any resentment or frustration, that is still what you experience when you think about your past, that tells me there's still room to process it. Now. We're not just going to work on the spiritual and energetic mental, emotional level. We need to look at the physical level. And what does the body need to turn on those ovaries. And this is where some really good testing comes into play so we can see what is the oxidative damage, Stress that your body is dealing with, where is the inflammation coming from for your body and how can we support that ovarian function? And I find there is the supplements, there's the biohacks, there's also the spiritual work, but then there's also a lot of physical work where you're getting some visceral massage or you're learning how to do it yourself, and you're connecting with your ovaries, you're connecting with yourself, you're connecting with your partner to help release some of these amazing hormones like oxytocin and prolactin in that help you feel safe and essentially regulate your nervous system. If you have a misalignment with your partner or you don't feel super connected with him, that's probably a stress that you're carrying. That's not helping the situation. So there's so many different components on how we can address this and how I address it. And what I will say is once I do the testing, then I can look at that. You know, what do we need to do to help this woman, this couple sitting in front of me have biological children. And the physiology of the ovary going from like a primary follicle, one that we cannot see on the ultrasound. So when we do an antro follicle count, you're looking at the ovaries that have been recruited for that cycle. But you don't see any of the, you know, there's the primary, there's the preantral, there's the antral, and then there's pre ovulatory. And that primary or primordial? Primary. The primordial one is the quote, unquote ovaries that are asleep. The follicles that are asleep, we don't see them. There's inhibitory and there's stimulatory factors. So there's factors that turn it on and get the process moving. And there's things that block it. And the things that block it are things like amh, for example. So the anti mullerian hormone helps us make sure that we as women don't ovulate all our eggs at the same time. Time. But then the. So that's good. We want that inhibitory factor, but other inhibitory factors that get that primordial follicle to start moving through and becoming an antero follicle and then potentially becoming the follicle that gets fertilized. Things like oxidative stress and inflammation and stress in general, nutrient deficiencies, blood sugar, dysregulation, excess weight, all of Those things will prevent those follicles from maturing because the body doesn't feel safe. Safe. And so on the opposite end of that, the things that will stimulate that follicle to grow into mature and to potentially fertilize are your CoQ10 and vitamin D and omegas and, you know, all these beautiful nutrients that, you know, that support mitochondrial function. So you have to address the inflammation, you have to address the toxin, and then you have to put the nutrients in so that follicle can go and start to mature. Because that process actually from that primordial, nobody sees it, nobody even knows it exists to the ovulatory is about nine to 12 months. So when you're only looking at the three month mark, you can impact the preantral follicle and the antral and the one that's, you know, the ovulatory one, but you're not impacting one, the deeper ones. And the deeper ones, that's our pool. And so when a woman is told she has premature ovarian insufficiency, sorry, you don't have any more eggs. Eggs. It doesn't necessarily mean that you don't have any more eggs. It just means that they don't feel safe and they're in rest zone. And so we have to remove some of the inhibitory factors and put some of the stimulatory factors. And that process on its own is about five months just for it to jump to the next stage. And then to the next stage is another two or three months and then it's two months and then it's, you know, 14 days. So I think the more that I learn and I study this and I understand the human physiology, then I can let my patients know to have this realistic expectation of how long it's actually going to take to improve the quality of the egg and how aggressive we need to be and what exactly is preventing the egg from maturing properly. And then obviously we're going to look at sperm health because the sperm health is so important for women, women whose eggs are already quote, unquote, struggling because the egg doesn't have the capacity to fix any damage within the sperm.

I don't know if you guys know this, but you will. Now, when the fertilization happens, the first thing that the egg does with its mitochondrial DNA and with its mitochondria, it's going to use up the energy to fix up any damage within the sperm first. So then that fertilization can, and you can, you know, go into the blastocys and the embryo and all that J as so if that sperm is rubbish and that egg is already, you know, barely making it like it just has what it needs and now you put the sperm in, that's really rubbish. The egg just gets completely overwhelmed. And this is when we're seeing really low fertilization rates, really poor embryo quality like the it doesn't even make it to blasted stage. So the sperm quality is really, really important for a man who, when a woman has premature ovarian or diminished ovarian reserve or you know, that poor egg quality. So there's lots that we can do we cannot like. The bad news is that you inherited what you inherited. The good news is that you can absolutely do things to reverse damage within the mitochondria and to decrease your own inflammation, to decrease environmental toxic load, to help the body detox and get this out and to restore the function of the over worry. It's just a lot more than I think most people realize in terms of what they need to do and how long they need to do it for. And like I said, there are these other therapies where it's PRP or stem cell therapy or even just traditional art, whether it's IVF or iui, where we can then use science if you will, and use technology to help us to nudge the body in the right direction. Don't get me wrong, as a natural fertility expert, I'd love for everybody to get pregnant naturally. For some couples it's not the case and they just might miss their window. So we work with what we need to, but we do it well. And when we've done all the work supporting the mitochondria and the methylation, I think that's been like the biggest thing that I've learned in the last year is so many women are coming to me and even if they had methylation tested and I was like, has this been addressed? And they're like, well they said they're not going to address it until the infection is gone. And it's like, no, you have to address methylation so then your body can overcome the infection. It cannot overcome the infection if the methylation isn't working. And methylation is like how our body repairs DNA, not just regular DNA, but mitochondrial DNA. So when I talking about DNA damage that passed on from our mother, like, well, how do we reverse it? Well, we fix methylation and we understand why that methylation was out of whack in the first place, which is usually the environmental toxic load, which is usually infections, blood sugar, DYSREGULATION all the stress, stress that needs to be addressed while we're supporting methylation. So I'm very excited about this time in a sense that I think we have an opportunity to reverse some really big things. And I'm very passionate about building generational health. I always say I'm not in the business of helping people get pregnant. I'm in the business of helping people have healthy children. And I think that's very different from just getting pregnant. I know that just getting pregnant is the beginning of this journey. And I have many couples right now who are, are, you know, going through that pregnancy, and we're watching and it's. If you've experienced a loss, at any loss. But one of my clients patients right now, she experienced a loss of 37 weeks. We're not. We're excited and there's milestones, but we're going to check her every six weeks during her pregnancy, and we're going to keep an eye on a lot of things to make sure that she feels supported and that we can bring the. This beautiful, healthy, live baby into her arms. I just think that there's so much to having healthy children than just getting pregnant. And if your mentality, like, if you switch to, yeah, I don't want to just get pregnant. I want to have a healthy baby. Let's make sure that the way that we approach it actually aligns with that. Again, just a couple who, like, decided not to move through the IVF cycle because they just feel like there's so many things that are wrong and unstable, if you will, in their life. And they're just kind of pushing through because they just think that, like, once they have the baby, then a lot of these things will resolve. And it's like, no, resolve the things and the baby will come. I appreciate you guys. I hope you find it helpful. I know it was a little bit of a rant, but there's a lot more to come out, and I will continue to update you. I think us ladies need to learn how to protect our ovaries. And if you have, like, I have two girls I am already thinking and teaching them about. I mean, I've taught them from the beginning, but I think about their ovarian health and how I want to make sure that they stay healthy. And, you know, my daughter is almost 8, and I'm like, I can't imagine her going to have her period. That would be crazy. A crazy responsibility and emotional change where, you know, she's still a kid and to becoming an adult and a caretaker seems a little bit young and we can absolutely reverse it with a good quality food and avoiding the toxins and giving our body the nutrients that it needs to function the way that it's supposed to. It's just we live in such a different world now and we have to become aware of it because we are passing down. And maybe you're listening to this and maybe you're the one that has a heavy burden and you have to work through that. So just know that I'm, I feel you. I'm with you. I want you to keep fighting and keep connect to your ovaries and ask yourself, what do I need to do to bring these back to life? Who do I need to work with with? What do I need to voice? What do I need to do for my work? Who do I need to become so I can feel these ovaries come back on and turn on? Thank you guys so much for listening and I'll see you next week. Thank you so much for listening. To read the full show notes of this episode, including summary, timestamps, guest quotes, and any resources that were mentioned on the episode, visit drjanelevesque.com forward slash podcast podcast and if you're getting value from these episodes, I'd love it if you took 2 minutes to share it with a friend. Rate and leave me a review@ratethispodcast.com Dr. Jane the reviews will help with the discoverability of the show. And who knows, I might share your review on my next episode. Thank you so much for tuning in and let's make your fertility journey your healing journey.

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