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23: Brushing at the Wrong Time? – The Hidden Reason Enamel Keeps Getting Weaker with Dr. Rob Karlinsey
Episode 2322nd December 2025 • Dental Formulator's Playbook • Dr. Rob Karlinsey
00:00:00 00:34:09

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What if the most important protection for your teeth isn’t in your toothpaste at all, but in the salivary proteins you may be unknowingly stripping away every day?

In this episode, Dr. Rob and Tami explore a critical but often overlooked aspect of oral health: the salivary proteins that naturally protect teeth. The conversation focuses on the acquired enamel pellicle, a protein rich layer that forms on enamel within seconds and plays a key role in defense, remineralization, and microbial balance.

They discuss how aggressive cleaning products, chronic whitening treatments, and poor brushing timing, especially after acidic drinks, can unintentionally damage this protective layer. The episode compares fluoride based approaches with peptide based technologies, explains why some treatments underperform clinically, and highlights how respecting the mouth’s natural biology leads to better long term outcomes.

Key Topics Covered

  1. What the acquired enamel pellicle is and why it matters
  2. The role of salivary proteins in enamel protection and remineralization
  3. How aggressive whitening and cleaning agents can disrupt oral defenses
  4. Why brushing immediately after acidic drinks accelerates enamel wear
  5. Differences between fluoride based and peptide based treatments
  6. Why some peptide technologies fail in real world clinical studies
  7. How salivary proteins influence tartar formation and erosion risk
  8. The importance of timing, pH, and product choice in daily oral care
  9. Why stannous fluoride works synergistically with salivary proteins
  10. Practical strategies to protect enamel without over stripping it

Practical Takeaways

  1. Avoid brushing teeth immediately after acidic drinks like orange juice, soda, or energy drinks
  2. Allow saliva time to rebuild the pellicle layer before mechanical brushing
  3. Be cautious with chronic use of highly alkaline, fluoride free, or protein stripping products
  4. Understand that “cleaner” does not always mean healthier for enamel
  5. Choose products that work with salivary proteins rather than against them
  6. Recognize that enamel erosion is permanent and prevention is critical

📲 Connect with Dr. Rob (Robert L. Karlinsey, PhD)

🌐 Website: customdentalformulations.com

📄 Research Profile: Robert Karlinsey on ResearchGate

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