Artwork for podcast Febrile
95: Viva Pediatric ID! Live from Memphis
Episode 9518th March 2024 • Febrile • Sara Dong
00:00:00 00:33:45

Share Episode

Shownotes

Drs. Sumanth Cherukumilli, Emma Mohr, and Paul Spearman join for a live Febrile recording at the St. Jude / PIDS Pediatric Infectious Diseases Research Conference in Memphis, TN.  They cover some learning points about early onset neonatal sepsis and chat about career development.  Thank you to the conference organizers for the opportunity!

Episodes | Consult Notes | Subscribe | Twitter | Merch | febrilepodcast@gmail.com

Febrile is produced with support from the Infectious Diseases Society of America (IDSA)

Transcripts

Sara Dong:

Hi, everyone.

Sara Dong:

I just wanted to give a quick introduction for this episode.

Sara Dong:

We were actually lucky enough to do another live recording.

Sara Dong:

This time we were at the 23rd Annual St.

Sara Dong:

Jude PIDS Pediatric Infectious Diseases Research Conference in Memphis, Tennessee.

Sara Dong:

So if you aren't familiar, this is a really awesome conference.

Sara Dong:

It features leaders in pediatric ID research, transplant and immunocompromised

Sara Dong:

host ID, and global health.

Sara Dong:

In addition to all these topics, there is an emphasis on career development.

Sara Dong:

So we are fortunate to have Dr.

Sara Dong:

Sumanth Cherukumilli, who is the top abstract winner and a pediatric ID

Sara Dong:

fellow at the University of Maryland, as well as faculty members, Dr.

Sara Dong:

Emma Mohr from the University of Wisconsin, and Dr.

Sara Dong:

Paul Spearman from Cincinnati Children's joining.

Sara Dong:

And just to provide a teeny bit of context for the podcast and a couple of

Sara Dong:

the questions in the q and a at the end.

Sara Dong:

This recording was completed after a presentation I provided on "How to develop

Sara Dong:

and evolve as a digital medical educator".

Sara Dong:

All right, so let's head to the conference.

Sara Dong:

Hi, everyone.

Sara Dong:

Welcome to Febrile, a cultured podcast about all things infectious disease.

Sara Dong:

We use consult questions to dive into ID clinical reasoning, diagnostics,

Sara Dong:

and antimicrobial management.

Sara Dong:

You now, at this point, know me.

Sara Dong:

I'm Sara Dong.

Sara Dong:

I'm your host and a MedPeds ID doc.

Sara Dong:

We have a live recording today.

Sara Dong:

We are at the to the St.Jude/PIDS Pediatric ID research conference.

Sara Dong:

Thanks to the audience for being here and we have three awesome guests so I'm

Sara Dong:

going to move down the table and ask them to say hello and introduce themselves.

Sumanth Cherukumilli:

I'm Sumanth.

Sumanth Cherukumilli:

I'm the second year Peds ID fellow from the University of Maryland.

Sara Dong:

And I would just like to introduce, we asked him to come on the

Sara Dong:

show because his project was selected as the top abstract for this meeting.

Sara Dong:

So, you'll get to see his presentation tomorrow.

Sara Dong:

But, thank you for joining.

Emma Mohr:

All right, I'm next on the table.

Emma Mohr:

My name is Emma Mohr, and I'm a pediatric infectious diseases

Emma Mohr:

physician and scientist at the University of Wisconsin Madison.

Paul Spearman:

Hi,

Paul Spearman:

my name is Paul Spearman.

Paul Spearman:

I'm vice chair for clinical translational research at Cincinnati

Paul Spearman:

Children's, and I'm here also as a MedPeds ID doc, but practicing

Paul Spearman:

Peds ID and because Emma asked me.

Paul Spearman:

Thanks.

Sara Dong:

And as everyone's favorite cultured podcast, we always ask if

Sara Dong:

our guests will share a little piece of culture, basically just something

Sara Dong:

non medical that makes you happy.

Sara Dong:

Please feel free to share something personal or you can also

Sara Dong:

share something about Memphis.

Sumanth Cherukumilli:

This is not personal or about Memphis, but I am a

Sumanth Cherukumilli:

big fan of trashy TV and Love is Blind has its wedding episode today, which

Sumanth Cherukumilli:

I'm very excited to watch later today.

Emma Mohr:

I really enjoy running, um, and so I run usually a couple times

Emma Mohr:

a week and especially love running on trails, and it helps clear my head from

Emma Mohr:

everything work and family related.

Paul Spearman:

All right, I have recently taken up sculpture,

Paul Spearman:

and I love doing sculpture.

Paul Spearman:

It's kind of a total break from everything else, both kind of

Paul Spearman:

classical sculptures and weird sculptures, so it's a lot of fun.

Sara Dong:

Well, I'm excited.

Sara Dong:

I wish we had a weird sculpture centerpiece.

Sara Dong:

We're going to open up with something sort of clinically oriented.

Sara Dong:

We wanted to share some clinical pearls, but then also shift a little bit at the

Sara Dong:

end to talk about career development.

Sara Dong:

And if we have time, we'll also open it up for questions.

Sara Dong:

So I have a mini case I'm going to pitch to Emma and Paul.

Sara Dong:

So you're getting called.

Sara Dong:

We have a baby boy born at 38 weeks, 5 days gestation, it's been about

Sara Dong:

24 hours ago, to a 32 year old G1, now P1, previously healthy mom.

Sara Dong:

Mom has become unwell, she's developed a fever, but outside of that her

Sara Dong:

antepartum course and labs have otherwise been negative and uneventful.

Sara Dong:

The baby was initially doing well, but has since developed a fever and worsening

Sara Dong:

respiratory distress, which led to transfer to the NICU for further workup.

Sara Dong:

He now has worsening hypotension, requiring pressor support, and

Sara Dong:

has been intubated and ventilated.

Sara Dong:

And so I was going to ask if you could talk us through what's going on here.

Sara Dong:

I know we have some earlier learners that maybe haven't been in the clinical setting

Sara Dong:

before, and how you would approach this.

Sara Dong:

Most importantly, we want to talk a little bit about empiric therapy.

Emma Mohr:

Sure, I'll take this early part.

Emma Mohr:

So, when I hear about a young baby, usually less than 3 days of age with

Emma Mohr:

signs of clinical distress, so sounds like the baby had some increased work

Emma Mohr:

of breathing, just not looking good, so other signs of not looking good

Emma Mohr:

could be things like lethargy or not feeding, not doing what a newborn baby

Emma Mohr:

is asked to do, which is not much, but you do have to wake up to feed yourself.

Emma Mohr:

When they're not doing that, we're worried about something like early onset

Emma Mohr:

sepsis or neonatal sepsis, especially less than three days of age or 72

Emma Mohr:

hours is what we usually think of that.

Emma Mohr:

And one of the things that we think about is, were they exposed

Emma Mohr:

to pathogens from the maternal GU or GI tract during the process of

Emma Mohr:

delivery, they can be transferred these bacteria and it can cause sepsis in

Emma Mohr:

them or pneumonia at times as well.

Emma Mohr:

So those are the things that I'm thinking about when I'm called

Emma Mohr:

to evaluate babies like this.

Paul Spearman:

Uh, and I agree completely with Emma on this.

Paul Spearman:

I think we have several concerning things.

Paul Spearman:

The maternal fever would already pique your interest that the baby

Paul Spearman:

could have a neonatal infection.

Paul Spearman:

It does sound like early onset neonatal sepsis.

Paul Spearman:

We don't know mom's GBS status.

Paul Spearman:

We'd want to know that, and that would also figure into the risk.

Paul Spearman:

But with the baby already having respiratory distress and hypotension,

Paul Spearman:

We don't really need a fancy neonatal risk calculator to say

Paul Spearman:

what we need to do next, right?

Paul Spearman:

Because this is so much in the category of neonatal sepsis that

Paul Spearman:

you'd want to start empiric therapy.

Paul Spearman:

And I guess that's our topic also for discussion is what would you,

Paul Spearman:

you know, what are the organisms that you would really be worried

Paul Spearman:

about and, and what would you start?

Paul Spearman:

So at the top, you'd still have group B strep, which is the number

Paul Spearman:

one for early onset neonatal sepsis.

Paul Spearman:

Then E.

Paul Spearman:

coli and other Enterobacteriaceae, I usually think of those

Paul Spearman:

together, although E.

Paul Spearman:

coli is by far the most likely you can have other gram negative sources of

Paul Spearman:

sepsis, and then a more distant third, Listeria, and we would maybe expect mom

Paul Spearman:

to have chorioamnionitis if there's a baby that we're thinking about Listeria.

Paul Spearman:

So we think about those kind of categories, and we'd be thinking

Paul Spearman:

largely of bacteria at this stage, but you'd want in the back of your

Paul Spearman:

mind to think of viral syndromes.

Paul Spearman:

This is a little early for presenting with disseminated HSV or enterovirus

Paul Spearman:

or parecho[virus] or something like that, but you'd want to not completely

Paul Spearman:

discount those and think about them.

Paul Spearman:

And if things are out of line, or if, let's say, the baby has really

Paul Spearman:

high LFTs, there's maybe a maternal history, you might think about

Paul Spearman:

herpes a little higher on the list.

Paul Spearman:

So fungal, probably not so much at this kind of early presentation and

Paul Spearman:

in a non premie [premature infant].

Paul Spearman:

Thank you.

Emma Mohr:

So what do we do with this baby when we're called?

Emma Mohr:

What labs do we recommend getting?

Emma Mohr:

And then how do we treat the baby?

Emma Mohr:

One of the big things that you do for these baby is evaluate

Emma Mohr:

their blood with a blood culture.

Emma Mohr:

Are they growing organisms in there?

Emma Mohr:

And you really, really try and get that blood culture before you start

Emma Mohr:

antibiotics so we can make an educated decision about what infection they have

Emma Mohr:

and what they should be treated with.

Emma Mohr:

So you get that blood culture and then right away administer

Emma Mohr:

antibiotics for this baby.

Emma Mohr:

So the empiric antibiotics that we think about for these children are

Emma Mohr:

things like ampicillin and gentamicin.

Emma Mohr:

So we want to make sure that we cover the common organisms that we just

Emma Mohr:

talked about, especially GBS and E.

Emma Mohr:

coli, which are the most common.

Emma Mohr:

Usually we think about sepsis over things like meningitis right away

Emma Mohr:

in an infant that's 24 hours of age.

Emma Mohr:

But as they get a little bit older than that, a few days

Emma Mohr:

later, maybe meningitis can happen more likely than sepsis as well.

Emma Mohr:

So ampicillin and gentamicin in these early days, and then later on, if we're

Emma Mohr:

really thinking meningitis and we want better CNS coverage, cephalosporin,

Emma Mohr:

something like ceftazidime or others.

Emma Mohr:

That's it.

Emma Mohr:

Sort of leading into what we're talking about next is what empiric antibiotics

Emma Mohr:

to use in our practice here in the U.

Emma Mohr:

S.

Emma Mohr:

Ampicillin gentamicin is good based on our common organisms, but it's not

Emma Mohr:

like that everywhere in the world.

Sara Dong:

Yeah, and that's kind of what we wanted to transition about

Sara Dong:

because often times we think about our differential and maybe don't always

Sara Dong:

remember about how screening practices may be different somewhere else.

Sara Dong:

I learned a lot about how GBS screening and prophylaxis varies

Sara Dong:

in different countries and I hadn't really thought about that much until

Sara Dong:

we had done a Febrile episode on it.

Sara Dong:

And I think neonatal sepsis rates are quite variable.

Sara Dong:

So Sumanth, I wanted to get your perspective because we wanted to

Sara Dong:

also adjust this case a little bit.

Sara Dong:

So we've said ampicillin/gentamicin for our sort of North American

Sara Dong:

audience, but what if we thought about it from a different perspective?

Sara Dong:

And I think that kind of plays into your research that you're presenting about.

Sumanth Cherukumilli:

Yeah, so I'm not sure if everyone is

Sumanth Cherukumilli:

familiar with the CHAMPS study.

Sumanth Cherukumilli:

It's a study that uses minimally invasive sampling techniques to look

Sumanth Cherukumilli:

at children who have died under the age of five in multiple countries,

Sumanth Cherukumilli:

mostly low and middle income countries.

Sumanth Cherukumilli:

They actually published from their analysis a paper last year that

Sumanth Cherukumilli:

looked at the causes of death in neonates between 2016 and 2021,

Sumanth Cherukumilli:

and the majority of neonates had an infection in their causal chain,

Sumanth Cherukumilli:

like in their causal chain of death.

Sumanth Cherukumilli:

The most striking thing, there's actually a chart that demonstrates

Sumanth Cherukumilli:

the burden of each infectious disease.

Sumanth Cherukumilli:

The most striking thing is how, in comparison to gram negatives,

Sumanth Cherukumilli:

GBS is not really as big a player in a lot of these different sites.

Sumanth Cherukumilli:

Like gram negative Enterobacterales are really the biggest killers, specifically

Sumanth Cherukumilli:

Klebsiella pneumoniae, and a lot of these isolates are multi drug resistant.

Sumanth Cherukumilli:

The WHO definitely recommends intrapartum antibiotic prophylaxis for GBS positive

Sumanth Cherukumilli:

moms, but what they write is that it's a conditional recommendation based on

Sumanth Cherukumilli:

weak evidence, and they have a lot of caveats in there about how it really

Sumanth Cherukumilli:

depends on your local epidemiology, and GBS screening is kind of a plus

Sumanth Cherukumilli:

or minus depending on where you are.

Sumanth Cherukumilli:

So, uh, If we just look at the mortality burden, gram negatives

Sumanth Cherukumilli:

are really the biggest players.

Sumanth Cherukumilli:

That's something definitely important to consider when we're talking

Sumanth Cherukumilli:

about empiric regimens and settings outside the United States and Europe.

Sara Dong:

Is there anyone in the audience who would not use ampicillin

Sara Dong:

gentamicin, you know, based on the most common organisms at their site.

Sara Dong:

Yeah.

Sara Dong:

I'm sorry, I don't have a mic for you.

Sara Dong:

I can repeat.

Sara Dong:

What is your empirical

Audience Member:

I think you said, it kind of follows up with what was just

Audience Member:

said about local rates, because our ampicillin susceptibility rates for E.

Audience Member:

coli are not satisfactory at all.

Audience Member:

They're probably about 50 percent.

Sara Dong:

Yeah.

Audience Member:

So we, very strongly encourage a third generation cephalosporin

Audience Member:

upfront plus or minus ampicillin if you're worried about Listeria and I think, and

Audience Member:

we have a very hard time getting our neonatologists to understand that because

Audience Member:

all the guidelines say amp and gent.

Audience Member:

But you really do need to use your local epidemiology to make that decision.

Sara Dong:

Hopefully, folks in the audience could hear most of that, but

Sara Dong:

just talking about the importance of looking at your local epidemiology.

Sara Dong:

And so if there is a high rate of ampicillin resistance, of course,

Sara Dong:

amp would not be the ideal agent.

Sara Dong:

Okay.

Sara Dong:

And so Sumanth, you know, before we move on, I just wanted to follow

Sara Dong:

up with you from your work because we talked about reframing this case

Sara Dong:

from a different perspective using different empiric antibiotics.

Sara Dong:

Are there any other considerations or challenges in management that you think

Sara Dong:

of in this case or based on your project?

Sumanth Cherukumilli:

The project that I've been doing is mainly in Mali.

Sumanth Cherukumilli:

It's a country in West Africa, which I'm sure many people are familiar

Sumanth Cherukumilli:

with, that has some of the lowest indices of development in the world.

Sumanth Cherukumilli:

And there we've actually been doing an invasive bacterial infection study since

Sumanth Cherukumilli:

2002 to look at the causes of bacterial infections in kids under the age of 15.

Sumanth Cherukumilli:

Initially, the burden was mainly just Hib and Strep pneumo, but the data that we got

Sumanth Cherukumilli:

from the study allowed Milagritos Tapia and Karen Kotloff, my two primary mentors,

Sumanth Cherukumilli:

to introduce vaccines in that setting that really reduced the burden of both.

Sumanth Cherukumilli:

But our burden of gram negative infections, gram negative

Sumanth Cherukumilli:

Enterobacterales specifically, has stayed pretty static and actually maybe

Sumanth Cherukumilli:

has gone up over this time period.

Sumanth Cherukumilli:

So I really looked at mortality rates between 2021 and 2024, really over a three

Sumanth Cherukumilli:

year period, and I found that kids who had a positive culture had a mortality

Sumanth Cherukumilli:

rate of 49 percent versus 28 percent in kids who had negative cultures, and

Sumanth Cherukumilli:

both are really unacceptably high rates.

Sumanth Cherukumilli:

The issue in Mali, and I'm sure this applies to other places

Sumanth Cherukumilli:

in Sub Saharan Africa, falls into like four major buckets.

Sumanth Cherukumilli:

Problems with diagnostics, problems with presentation, problems with antibiotics,

Sumanth Cherukumilli:

and problems with supportive care.

Sumanth Cherukumilli:

With diagnostics, there's issues.

Sumanth Cherukumilli:

We are able to get blood cultures in Mali, but that's because, you know, it's

Sumanth Cherukumilli:

supported by a major American institution, but there are lots of places in Mali and

Sumanth Cherukumilli:

Sub Saharan Africa where you can't really get blood cultures, so you don't have

Sumanth Cherukumilli:

anything to really guide your therapy.

Sumanth Cherukumilli:

That's really a diagnostics issue, and other than microbiologic diagnoses,

Sumanth Cherukumilli:

like, forget about molecular testing.

Sumanth Cherukumilli:

When cultures are difficult.

Sumanth Cherukumilli:

It's also difficult to get labs, things we take for granted like CRPs,

Sumanth Cherukumilli:

lactates, procalcitonins, things like that, which can make it really hard

Sumanth Cherukumilli:

to assess, especially in patient where infection can be subtle, like a neonate,

Sumanth Cherukumilli:

where your patient really stands.

Sumanth Cherukumilli:

And then there's issues with presentation.

Sumanth Cherukumilli:

And again, I put this into like two different categories, right?

Sumanth Cherukumilli:

So there's the issue with delay in presentation where kids maybe

Sumanth Cherukumilli:

live really far away from the hospital, don't have transport to

Sumanth Cherukumilli:

get to the hospital, and where.

Sumanth Cherukumilli:

So, parents just aren't aware of what a sick kid looks like so they

Sumanth Cherukumilli:

present in extremis and it can be really difficult to treat those kids.

Sumanth Cherukumilli:

And that's kind of borne out by our data where greater than 50 percent

Sumanth Cherukumilli:

of kids who die, really die within the first 48 hours of presentation.

Sumanth Cherukumilli:

And then the other issue I think with presentation is um.

Sumanth Cherukumilli:

And then there's seeking care in the community before they come to the

Sumanth Cherukumilli:

hospital, and that can be with traditional healers, where they get medications,

Sumanth Cherukumilli:

we don't know what sometimes is in those medications, those medications

Sumanth Cherukumilli:

themselves can be toxic, and you can get sub therapeutic concentrations of

Sumanth Cherukumilli:

antibiotics in those medications as well.

Sumanth Cherukumilli:

And then some of these kids get treated out in the community, where they can

Sumanth Cherukumilli:

get injectable antibiotics, but again, they're not getting cultures, so you can

Sumanth Cherukumilli:

have kids that are partially treated, who limp along, limp along, limp along,

Sumanth Cherukumilli:

until they present in overwhelming shock and then antibiotics, right?

Sumanth Cherukumilli:

And I, again, I kind of grouped this into 2 separate categories.

Sumanth Cherukumilli:

The 1st 1 is that, you know, 100 percent of our E.

Sumanth Cherukumilli:

coli strains are resistant to ceftriaxone over the last 3 years.

Sumanth Cherukumilli:

And that number is greater than 90 percent for Kleb pneumo.

Sumanth Cherukumilli:

So, per Pranita Tamma's excellent talk on your podcast a few months ago,

Sumanth Cherukumilli:

really, if you're thinking about an ESBL organism in a critically ill patient,

Sumanth Cherukumilli:

the treatment of choice is a carbapenem.

Sumanth Cherukumilli:

And it's really hard to get access to carbapenems in that setting

Sumanth Cherukumilli:

because the onus is really on the parents to buy the antibiotics.

Sumanth Cherukumilli:

And these antibiotics are very, very expensive.

Sumanth Cherukumilli:

And so kids get treated with ineffective antibiotics like ceftriaxone and

Sumanth Cherukumilli:

aminoglycosides, which again, have mortality, like, uh, resistance rates

Sumanth Cherukumilli:

of greater than 50 percent to the most commonly isolated gram negative pathogens.

Sumanth Cherukumilli:

And then the other issue that I think is a global problem is the issue of

Sumanth Cherukumilli:

counterfeit and substandard antibiotics and antimalarials, which is really a

Sumanth Cherukumilli:

huge problem in sub Saharan Africa.

Sumanth Cherukumilli:

So even when you're getting the proper antibiotics, if you're not getting

Sumanth Cherukumilli:

them from a good source, there's a high probability that what you're getting

Sumanth Cherukumilli:

isn't good enough to treat your infection.

Sumanth Cherukumilli:

And that I think drives mortality and further antimicrobial resistance.

Sumanth Cherukumilli:

The last issue is supportive care.

Sumanth Cherukumilli:

And again, I think that it falls into two categories.

Sumanth Cherukumilli:

What we don't have, which in sub Saharan Africa, oftentimes, it's really hard

Sumanth Cherukumilli:

to find mechanical ventilators as well as continuous vasopressor support.

Sumanth Cherukumilli:

And then the problem is what we do have.

Sumanth Cherukumilli:

There's a famous trial that came out in 2011 that looked at the

Sumanth Cherukumilli:

impact of fluid boluses on patient mortality in East Africa in settings

Sumanth Cherukumilli:

without mechanical ventilation.

Sumanth Cherukumilli:

It's called the FEAST trial.

Sumanth Cherukumilli:

It's an excellent paper.

Sumanth Cherukumilli:

They divided them into several different cohorts, and they looked

Sumanth Cherukumilli:

at the impact of fluid boluses on patient mortality in all these kids.

Sumanth Cherukumilli:

They found that no matter what type of fluid they got, kids with

Sumanth Cherukumilli:

boluses had a significantly higher 48 hour mortality rate than kids

Sumanth Cherukumilli:

who did not get fluid boluses.

Sumanth Cherukumilli:

And these are all kids with suspected bacterial infections, suspected sepsis.

Sumanth Cherukumilli:

And this is a stunning result because for a long time, the standard of care in

Sumanth Cherukumilli:

the United States and worldwide was if you think someone has shock or sepsis or

Sumanth Cherukumilli:

something like that, you know, fluids are really fluids, fluids, fluids, 60 cc's per

Sumanth Cherukumilli:

kg in the first like 20 minutes of care.

Sumanth Cherukumilli:

And this pushed back against that idea that fluids were always beneficial.

Sumanth Cherukumilli:

Authors did a secondary analysis a few years later where they found that

Sumanth Cherukumilli:

the majority of kids who died from that initial trial died because they

Sumanth Cherukumilli:

had a cardiovascular collapse, not respiratory failure, which suggests

Sumanth Cherukumilli:

that some kids may have some degree of subacute myocardial dysfunction when

Sumanth Cherukumilli:

they present with sepsis or septic shock that might make it dangerous

Sumanth Cherukumilli:

to administer a lot of fluid therapy.

Sumanth Cherukumilli:

When you don't have hemodynamic monitoring like we do here with CVP, SVO2, or

Sumanth Cherukumilli:

renal NIRS, it's really hard to tell where we are in our resuscitation,

Sumanth Cherukumilli:

which can make it so that we provide harmful amounts of fluid therapies

Sumanth Cherukumilli:

that could potentially be beneficial.

Sumanth Cherukumilli:

And I think all of these things really contribute to the mortality

Sumanth Cherukumilli:

burden in a place like Mali.

Sumanth Cherukumilli:

It's a lack of resources, but also a problem with the resources

Sumanth Cherukumilli:

that we do have in that context.

Sumanth Cherukumilli:

I wouldn't be able to do any of this work if it wasn't for the wonderful

Sumanth Cherukumilli:

work that's been done by Millie Tapia and Karen Kotloff, my two primary

Sumanth Cherukumilli:

mentors, Samba So, Adiba Mambiketa, who have been working on the ground

Sumanth Cherukumilli:

to introduce a lot of these vaccines and therapeutics to Malian children

Sumanth Cherukumilli:

and have saved countless Malian lives.

Sumanth Cherukumilli:

Will Still is still one of the co authors on my abstract.

Sumanth Cherukumilli:

He's a PhD student who's been working on the impact of supportive

Sumanth Cherukumilli:

care on patient mortality and this population and a lot of the data that

Sumanth Cherukumilli:

he actually came up with informed the hypotheses that led to my project.

Sumanth Cherukumilli:

Finally, University of Maryland is a wonderful place to train.

Sumanth Cherukumilli:

If you're considering a fellowship centered around global health and

Sumanth Cherukumilli:

pediatric infectious diseases in a global setting, can't do much better than us.

Sumanth Cherukumilli:

We have a really wonderful track record of obtaining funding for fellows and

Sumanth Cherukumilli:

partnering people with faculty who are actually working on high impact

Sumanth Cherukumilli:

projects in low resource settings.

Sumanth Cherukumilli:

My mentors from residency, Tom Boyce, who's here right now actually, he's, he is

Sumanth Cherukumilli:

a huge inspiration for me, so I have a lot of people to think and I definitely still

Sumanth Cherukumilli:

have a lot to learn and hopefully can continue to contribute in any way I can.

Sara Dong:

Wow, that is just the perfect transition and giving a shout

Sara Dong:

out to your mentors and collaborators.

Sara Dong:

Just like this conference, we're getting a mix of clinicals.

Sara Dong:

I'm actually going to pivot.

Sara Dong:

I'm not going to give you the end of the case.

Sara Dong:

So it's just a sneak peek because we actually wanted to talk a little

Sara Dong:

bit about careers in pediatric ID.

Sara Dong:

So I actually was hoping that Emma and Paul could just tell us a little bit

Sara Dong:

about your career path and maybe one thing that you've, a piece of guidance that

Sara Dong:

you would give to a fellow who's trying to figure out what do I want to do, what

Sara Dong:

kind of pediatric ID doctor I want to be?

Emma Mohr:

Oh, what a great question because there's so many

Emma Mohr:

options as we've learned during our career paths session today.

Emma Mohr:

I've been set from pretty early on that I wanted to do research and

Emma Mohr:

medicine, so I think I've wanted to be a physician scientist for a long

Emma Mohr:

time, but I was always scared by the scientist piece because that seemed big

Emma Mohr:

and scary and the big world unknown.

Emma Mohr:

I didn't start believing that I could actually do that until later in

Emma Mohr:

fellowship, that I could fund my way to doing that and have my own research lab.

Emma Mohr:

So I encourage people who are in fellowship to really explore your options.

Emma Mohr:

You never know when you're going to be, I don't want to say in the right

Emma Mohr:

place at the right time, but when you are going to be called upon because

Emma Mohr:

you are the best option for some need that your institution or your lab has.

Emma Mohr:

My opportunity to really establish my research niche fell when

Emma Mohr:

I was in fellowship and my PI mentor, he's a straight PhD

Emma Mohr:

scientist, wonderful person, Dr.

Emma Mohr:

David O'Connor at the University of Wisconsin Madison, his area was

Emma Mohr:

in developing non human primate models of infectious diseases.

Emma Mohr:

And my fellowship happened to fall right during the time of the Zika

Emma Mohr:

pandemic throughout the Americas.

Emma Mohr:

And so we, uh, developed the first model of Zika virus

Emma Mohr:

infection in non human primates.

Emma Mohr:

As a pediatrician and peds ID fellow, I was really, really interested

Emma Mohr:

in understanding what happens to the infants after they're born.

Emma Mohr:

And these virologists that I was working with are like, what?

Emma Mohr:

What's developments?

Emma Mohr:

What does that mean?

Emma Mohr:

What does it mean like to have neurodevelopmental

Emma Mohr:

deficits or microcephaly?

Emma Mohr:

So I was really able to add the pediatrician piece to

Emma Mohr:

that and establish myself.

Emma Mohr:

That was really a wonderful experience and I thank you for that opportunity to

Emma Mohr:

add these other things to the project that would not have been there initially.

Emma Mohr:

But that was sort of my experience of using the skills that I had to

Emma Mohr:

answer a clinical need that came up.

Emma Mohr:

I was there when it was needed.

Emma Mohr:

And so now I run my own research job and it's wonderful, great experience,

Emma Mohr:

and I've been fortunate to be involved in these career development sessions

Emma Mohr:

and invite wonderful people from all over the country in different clinical

Emma Mohr:

niches to help talk with current ID fellows and younger trainees about all

Emma Mohr:

the different options within our field.

Paul Spearman:

Maybe we are a somewhat skewed kind of population here because

Paul Spearman:

I also am a lab based scientist and went into that during the HIV pandemic,

Paul Spearman:

the early days of the HIV pandemic, when it was really the mystery illness

Paul Spearman:

at the time and so much to learn.

Paul Spearman:

And I wanted to help with that.

Paul Spearman:

And so I sought out actually a fellowship where I I could join a retrovirology

Paul Spearman:

lab and become a retrovirologist.

Paul Spearman:

So that was sort of the early years.

Paul Spearman:

And it's been a great career.

Paul Spearman:

So let me just more generalize, because as division chief at two institutions,

Paul Spearman:

I have come to appreciate the value of all of the things that we do in Peds ID.

Paul Spearman:

We used to maybe have a field bias toward basic research,

Paul Spearman:

maybe, but we never should have.

Paul Spearman:

I mean, clinical research, epidemiology, service oriented work, antimicrobial

Paul Spearman:

stewardship, infection prevention, government work, industry work, it's all

Paul Spearman:

incredibly valuable, and I appreciate that in the faculty that I've had a

Paul Spearman:

chance to work with over the years, and in trying to help them just find

Paul Spearman:

what is the passion that they have.

Paul Spearman:

What part of the field, first of all, are they, are they really good at?

Paul Spearman:

And that often marries up with what they're really passionate about.

Paul Spearman:

And how can you develop that into a lifelong career

Paul Spearman:

that's very, very satisfying?

Paul Spearman:

So that has been enlightening and opens up to all of these different areas of

Paul Spearman:

Pete's ID that are great opportunities.

Paul Spearman:

Another thing I'll just comment on is that we have a lot of leadership

Paul Spearman:

opportunities as you go on.

Paul Spearman:

You all will have chances.

Paul Spearman:

You may.

Paul Spearman:

may or may not be inclined that way, but being a division

Paul Spearman:

chief is a terrific way to go.

Paul Spearman:

It's a great job.

Paul Spearman:

Uh, or being a leader within a division, a clinical director, all fellowship

Paul Spearman:

director, all of those things.

Paul Spearman:

And then some of us also take on institutional leadership responsibilities

Paul Spearman:

that maybe it's a shift, but it's still, you get to benefit a lot

Paul Spearman:

of people and do a lot of good.

Paul Spearman:

You want to find what you're passionate about, and as you go along in your

Paul Spearman:

career, you want to know yourself and what makes you tick and when you need

Paul Spearman:

to take the kind of break that Sara was talking about earlier, when you need

Paul Spearman:

a reboot, and be sensitive to that.

Paul Spearman:

One thing I have found helpful, just in my personal journey, is to occasionally

Paul Spearman:

do some journaling, where I'm talking to myself, basically, and then I look back.

Paul Spearman:

Sometimes months, sometimes years later, and I can kind of see where

Paul Spearman:

I've been and what I was thinking, and it's a tool that some people use.

Paul Spearman:

There are many other ways to do it, but I've found that really useful.

Sara Dong:

Okay, so we have a little bit of time, and I wanted to open it

Sara Dong:

up so that if anyone wanted to ask some questions, and you're welcome to

Sara Dong:

ask questions about career development or comments on the case from earlier.

Emma Mohr:

Could they also ask questions about your presentation

Emma Mohr:

that you just finished?

Sara Dong:

Mine?

Sara Dong:

Yeah.

Sara Dong:

I mean, if, sure.

Sara Dong:

Go for it.

Sara Dong:

Shreya?

Sara Dong:

Looks like there's a mic coming for you.

Shreya Doshi:

Sara, that was a great presentation, very

Shreya Doshi:

inspiring career trajectory.

Shreya Doshi:

When you were looking for jobs, and I know mostly people are looking for

Shreya Doshi:

clinic, clinicians to do clinical work.

Shreya Doshi:

How did you pitch that I also want to, you know, continue pursuing

Shreya Doshi:

this other interest I have, which I'm very passionate about?

Shreya Doshi:

Thank you.

Sara Dong:

So I was looking at heavy clinically oriented jobs.

Sara Dong:

I was usually just pretty honest.

Sara Dong:

I think that a lot of the projects that I had done before expressed for me that

Sara Dong:

those were important and I tried to just share my story of, you know, these are my

Sara Dong:

interests and how I've sort of weaved them together and trying to brainstorm about

Sara Dong:

how that could be incorporated into a job.

Sara Dong:

I will not say that I have it figured out.

Sara Dong:

I don't think that any medical education job right off the bat is

Sara Dong:

going to be easy, because some of that right place, right time is true.

Sara Dong:

There is only a certain number of educational leadership roles, and they're

Sara Dong:

not going to always be open when you go.

Sara Dong:

But if you have a division that is passionate about incorporating medical

Sara Dong:

educators, as it's part of their mission that they'll find creative ways to build

Sara Dong:

that in when you start until you have time to get your feet under you and look

Sara Dong:

for those roles that might have true sort of support and FTE behind them.

Sara Dong:

So I am kind of lucky in my position now I'm getting supported through my

Sara Dong:

division to spend time on my medical education activities to hopefully

Sara Dong:

build them out to where they are into roles that either in educational

Sara Dong:

leadership or something similar.

Sara Dong:

Being upfront and honest because that all those divisions that are

Sara Dong:

going to be excited to talk to you are going to tell you what they're

Sara Dong:

able to do and what they don't think that they can and be honest with you.

Sara Dong:

So I think the best thing you can do is say, this is what I'm really motivated by.

Sara Dong:

And then just try to think creatively about are there these are all things

Sara Dong:

that can overlap with your interests and you can marry them together.

Sara Dong:

Other thoughts from not the brand new attending?

Paul Spearman:

No, your perspective is great.

Paul Spearman:

I mean, you're closer than we are to like, when you start, you want to go into that.

Paul Spearman:

And so, you know, I think that's a really important thing to remember.

Paul Spearman:

I think that when you're looking for a position with an idea of what you want

Paul Spearman:

to do and just express it well, and you don't want to go in and be kind of

Paul Spearman:

flat and not say what your passion is.

Paul Spearman:

To me, that's really important when you're trying to hire someone.

Paul Spearman:

And it could be clinical work, it can be a mix of clinical and education,

Paul Spearman:

it can be any of these other things.

Paul Spearman:

But just knowing that.

Paul Spearman:

And then maybe showing something you've done that expresses that

Paul Spearman:

during your fellowship, that expresses that special interest.

Paul Spearman:

It's very helpful to the people that are doing the hiring.

Emma Mohr:

I was going to say also being able to express your passion

Emma Mohr:

gives you something to talk about during the multiple interviews

Emma Mohr:

that you're going to have that day.

Emma Mohr:

So you're going to have to talk about it over and over again.

Emma Mohr:

So you want to make sure you really love it and you're really excited about it.

Natasha Halasa:

As someone who's been, gosh now, over 20 years in the field,

Natasha Halasa:

and that's the first time I'm hearing about Febrile, and everyone who raised

Natasha Halasa:

their hand are probably within five years of fellowship, which is great.

Natasha Halasa:

But you hit on a point for promotion, and I think we as leaders, or people talking

Natasha Halasa:

to the leaders and talking to the chairs, for promotion, we need to be the ones that

Natasha Halasa:

need to be educated on this is how the new learners are learning, and how important

Natasha Halasa:

it is, and that we need to start changing.

Natasha Halasa:

So that's why I'm excited to be part of the promotion committee to

Natasha Halasa:

say, is there a digital platform?

Natasha Halasa:

How are people being innovative as someone who sits on the

Natasha Halasa:

promotion committee for VMC?

Natasha Halasa:

Like if I would see your CV, I think there's, uh, enough of us that would

Natasha Halasa:

advocate to say like this is where she's excelling in education and so I just

Natasha Halasa:

want to commend you on that and it was inspiring and I already sent it to all

Natasha Halasa:

the faculty and fellows that are not here to say this is something that we

Natasha Halasa:

need to incorporate in our teaching for learners because you helped you did a

Natasha Halasa:

lot of the legwork and we should be able to take advantage of it And so thank you

Sara Dong:

Thank you.

Sara Dong:

Most places you can look up if your institution just online has those metrics

Sara Dong:

like that impact grid I showed you.

Sara Dong:

Hopefully you are friends with people who are in places that can

Sara Dong:

advocate for changes to that if you are an institution that does not

Sara Dong:

lean towards having opportunities for digital scholarship to show impact.

Sara Dong:

So it's nice.

Sara Dong:

The one I showed everyone has for example like granular metrics and that's for

Sara Dong:

example what I put in the publication to say there's no way to actually tell you

Sara Dong:

the impact of Febrile, but based on this one grid, this is sort of where they would

Sara Dong:

decide, and I think everyone has to judge for themselves, but ultimately that's the

Sara Dong:

goal, to make it part of, of all the other types of great work that people are doing.

Emma Mohr:

Can we take just a second and say all of us here on the panel

Emma Mohr:

in the room think Pediatric ID is the greatest specialty and we hope,

Emma Mohr:

we hope all the listeners are considering a career in Pediatric ID.

Sara Dong:

Nick's asking a question.

Sara Dong:

My co fellow.

Nick Venturelli:

So how do you advocate, a lot of medical schools are now doing it.

Nick Venturelli:

I think we've done an okay job at integrating some of these new teaching

Nick Venturelli:

technologies and methods, especially for adult learners, but there's

Nick Venturelli:

still a lot of work to be done.

Nick Venturelli:

A long way to go, and especially in, as you kind of move along in your training

Nick Venturelli:

and get a lot of hour to hour and a half sessions of slides being read to you.

Nick Venturelli:

How do you, how do you advocate for like integrating more of

Nick Venturelli:

these interactive technologies and interactive teaching sessions into

Nick Venturelli:

our medical education landscape?

Sara Dong:

That is one of the next frontiers for digital education

Sara Dong:

is how to either make things that are standalone curricula or build

Sara Dong:

them into either rotations or local curriculums and rotations.

Sara Dong:

I don't have a great answer because I do think it's a little institution dependent,

Sara Dong:

but pitch these to educational leaders.

Sara Dong:

Oftentimes there are spare blocks in residency lecture spots where

Sara Dong:

they would love to do something creative and out of the box.

Sara Dong:

The other example I'll give is the escape room.

Sara Dong:

I don't know how many people were able to participate in the ID Week escape room.

Sara Dong:

That was just a, you know, that was a pitch to the ID Week sessions proposal.

Sara Dong:

So I think a lot of times you just have to throw out those ideas and maybe they don't

Sara Dong:

stick the first time, but eventually it'll open up and a lot of the medical students

Sara Dong:

are advocating for these as resources, so hopefully that will eventually help.

Sara Dong:

So I don't have an easy answer, but I think it's suggesting ideas and,

Sara Dong:

and try them out and pilot things.

Sara Dong:

And if they go well, then you build off of it and refine it.

Sara Dong:

And the other plug I'll give is if you do something like that and it's successful,

Sara Dong:

tell other people and try it out at other centers and like submit it to something

Sara Dong:

like MedEdPortal so that people can replicate it at their own institutions.

Sara Dong:

And then you've made your work count multiple times.

Sara Dong:

Okay.

Sara Dong:

Well, I think that wraps it up for our episode.

Sara Dong:

Thanks everyone.

Sara Dong:

Thanks so much to you, Sumanth.

Sara Dong:

Paul and Emma for joining Febrile, to the audience for their participation,

Sara Dong:

and to the organizers of the St.

Sara Dong:

Jude PIDS conference.

Sara Dong:

This was really fun.

Sara Dong:

As always, don't forget to check out the website, febrilepodcast.

Sara Dong:

com, where you will find the Consult Notes, which are written complements to

Sara Dong:

episodes, our library of ID infographics, and a link to our merch store.

Sara Dong:

Febrile is produced with support from the Infectious Diseases Society of America.

Sara Dong:

Editing and mixing is provided by Bentley Brown.

Sara Dong:

Please reach out if you have any suggestions for future shows or want

Sara Dong:

to be more involved with febrile.

Sara Dong:

Thanks for listening, stay safe, and we'll see you next time.

Chapters

Video

More from YouTube