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Takeaways:

1. In 2025, numerous unforeseen events transpired, leading to significant personal growth and gratitude.
2. Injecting peptides in the glute region can help avoid visible bumps, making it a preferred site.
3. For individuals with autoimmune diseases like Hashimoto's, Thymosin Alpha 1 and KPV are recommended for immune balance.
4. Lifestyle changes, including increased protein intake and regular exercise, are essential for maximizing the effects of GLP peptides.
5. Stress the importance of consulting knowledgeable healthcare providers regarding peptide use and lifestyle changes.
6. When transitioning between different peptides, one must be aware of potential desensitization, which may affect efficacy.

Welcome back everyone.

It is Monday, December 22, so we are right in the thick of Christmas week.

So as we close this year out, I just wanted to make sure that I put that out there to each and every one of you who listen.

Maybe if you're traveling, hopefully this will give you something to listen to.

And today I'm going to do round two.

Of all the questions that you asked, I thought about waiting and doing this next month and doing a different topic, but I thought, nope, this is a great way to close out the year because I did not get through all of them last time and y' all truly did ask me some great questions, ones that made me have to pause and think.

I learned so much from each and every one of you as well, and I'm super grateful for that.

So let's dive in.

I'm gonna pick up where we left off.

I made a little note here of where to start.

Okay, here we go.

First question.

I know GHKCU can be done upper glute subcube, but I also pin others there I e Tirzepatide.

I think what you're asking is can you inject other peptides in the glute area and not just in the abdomen, which I know is the common place that you hear of.

The answer is yes.

I usually exclusively inject in the glute because when you're lean in the midsection it tends to leave bigger bumps.

I try to avoid that and you can't see it so much in the glute and most people have more fat there.

So the answer is yes, you can inject there.

What is the best stack for people with Hashimoto's and other autoimmune diseases?

This is a good question and one I get quite a bit when it comes to Hashimoto's.

The real issue is not just the thyroid, it's the immune system attacking it.

I like to Recommend Thymos and Alpha1 because it's studied for how it helps immune signaling.

So instead of overstimulating or suppressing the immune system, it helps guide it towards better balance and immune tolerance, which is key for autoimmune conditions like Hashimoto's.

I also like recommending KPV because it's a powerful anti inflammatory peptide and it's researched for its ability to calm things like inflammatory cytokines and reduce immune driven inflammation that can irritate things like the thyroid.

We know that a lot of autoimmune stuff stems from chronic systemic inflammation.

That's where the Kpv comes in.

The thymosin alpha 1 and the Kpv are often a very supportive combo and I typically see people do really well on it.

I tell people to start with half the dose for the Thymosin Alpha 1 just to make sure that you're going to tolerate it okay and it doesn't cause a flare up or cause you to be more symptomatic.

I'm always a believer in starting really slow on that.

All right.

Okay.

How do I get the most from a glp?

Or how do you get the most from your glp?

That's a good question.

And it's not just a singular answer.

There's a lot of things that I think is super important when you're taking a GLP that often people just overlook.

Because, look, we all want that easy magic button that, let's just take this injection once a week.

You all of a sudden you've met your goal weight in all those things.

But GLPs are far more reaching than just weight loss.

I don't even really like to consider them a weight loss peptide, even though that's why they're popular, because they do so many other things.

The biggest issue I see is people don't change their lifestyle.

The GLP peptides only get you so far.

You have to be eating enough protein, you have to be hitting the gym, you have to be making those lifestyle changes.

If you're not willing to do that, then you're wasting your time because ultimately it's going to backfire on you.

And you can't just keep taking a GLP at higher doses and expecting the results you want.

If you're not making any other changes in your life, that can often be overwhelming.

So when I consult with people, I encourage them to start slow.

Start with one thing.

I did a podcast very early on when I first started doing this a couple years ago.

Please forgive me if you go back.

Listen to your hips.

I learned a lot since then, but it was about the one thing focusing on the one thing.

So you get on a GLP and maybe you're not ready to hit the gym, but start with your protein.

Say, I'm gonna get one gram per desired lean mass body weight that I want.

If you weigh 180 pounds and you want to weigh 140 pounds.

Try to eat 140 grams of protein every day.

Start with that one thing.

And then when you do, once you do that and that GLP is going to help take away that food, then you start layering in.

I'm going to get 10,000 steps in.

Maybe you start with 5,000, but then you start getting the movement in.

And then you can start getting the stamina to do the strength training and all that.

And start with one thing and build off that.

Don't overwhelm yourself with trying to do it all at once.

But that's going to really help you get the most out of your glp.

Taurine is a really good supplement.

I mentioned this last time.

The recommended dose is pretty high, like one to two grams.

I forget.

I always get it confused.

I take it, but I always get confused.

Let me look real quick.

Okay.

Two grams is what I take every day.

I've heard people taking as high as 5 grams.

I think 2 is probably plenty of.

But it in general helps peptides work more effectively.

And there's more and more research coming out about how taurine is just a really good supplement.

So that's something you could consider.

I've heard people say that an aloe supplement can help with the gastrointestinal issues some people have on the GLPs.

But really, lifestyle changes are what's going to help you.

Your nutrition is the first piece and then your workouts will be the second.

How to talk to others I. E. Dr.

Slash family about peptides we're using.

This is a great question, and I always say you can start with.

Peptides are just short chains of amino acids and they're signaling molecules that your body already uses to communicate.

So they're wildly different than pharmaceuticals that most doctors and most of your family members are going to be more well versed in or more comfortable with, which is crazy if you think about it.

It's the pharmaceuticals that are so harmful.

If we can use the peptides to keep us from having to use pharmaceuticals, we're gonna live a longer, healthier, more fulfilling life.

But people that don't understand peptides aren't gonna know that.

And in some ways it's an uphill battle.

I'm not gonna lie.

So I would say if you have a doctor that's not supportive of your use of peptides, find a functional practitioner.

Normally they are more versed and more open to peptides.

Don't just stick with a doctor that's not going to listen to you and has no knowledge of this.

You can't expect people that don't have any knowledge of it to think that it's okay to inject yourself with something if you put yourself in their shoes and think about how you thought about that or would have thought about that before you really understood peptides.

You can understand why it's sometimes a difficult conversation to have.

But you pay your doctor to to treat you and to help you with your health optimization and longevity and wellness plan.

So if that doctor is not working for you, be empowered to change that and find one that will.

As far as family members, I don't really think you can worry about that.

I have family members that think I'm cuckoo.

They love me and I love them, but we're just not going to see eye to eye.

So I quit trying to plead my case.

If they ask me questions, I answer them.

And lots of times people will say, man, your skin looks great.

What are you doing?

Or how do you stay in shape at your age?

And how do you keep the weight off at your age?

That's a really easy segue.

Start talking about peptides.

And living by example sometimes can be the best thing you can do without saying a singular word.

So you have to advocate for yourself with your healthcare providers and let your family and friends see you live your life in a way that makes them attracted to that and they want to know more.

You're not even really having to defend it.

They want whatever it is you have.

That has been my experience with that.

Next question.

How do you know what is working and what's not?

If you stack something like CLO with Cardilax, is it better to do one than the other?

I have been on CLO for one week and I noticed slight weight gain.

How do you know what's working and what's not?

You don't.

And that's the easy question.

I always tell people to start separately with peptides so you can know what works for you.

However, I'll give you an example where I break that rule.

My mother in law fell yesterday and I'm heading to our family ranch tomorrow and I will see her and I'm bringing some peptides with me and I'm going to stack them.

But she is in pain and injured and it's right before the holidays so she's not going to go see a doctor right now and I just want to get her healed up as quickly as possible.

I'm not gonna waste the time when she's in pain and discomfort.

I know she needs healing and I'm gonna throw everything I've got at her.

If you have some little aches and pains here and there and you're taking the clothes, see if it works for you, that might work entirely on its own.

Or maybe the CLO got you to a certain point in healing something, but you didn't fully get there.

So then you layer in something like cardillacs, and that might be what actually pushes you over the edge of.

Oftentimes you're not gonna get the benefit you want with these on their own, but combined you will.

And so you kind of have to play around with it.

So that's probably not the best answer, but it's the one I'm giving you.

Okay.

And then on the weight gain, that would not be normal, but I've learned never to say never with these things.

That's just not typical.

Let me say that.

I guess in theory, if your body is recalibrating and these signaling peptides are doing their thing, you could potentially be retaining some water.

The body's just holding on to some things as you're recalibrating, and maybe you've seen a little bit of weight gain.

I don't know for sure.

It should subside after a little bit of use.

Hang in there and see if that dissipates.

I don't know if that's actually due to the peptide or not.

All right.

Could you take Tis a fene a day during the week that you.

For the week?

Yeah.

Because the caggery it's full impact doesn't happen immediately.

That is a lot of appetite suppression.

If you're taking both and be careful and make sure you're getting enough protein.

They do totally different things, work on different pathways.

There really shouldn't be much interaction.

The main reason people take those is for the appetite suppression.

In theory, tis a feene can give you an energy boost where the caggery can make you tired.

So in theory, those may offset each other.

You have to be your own n of 1 in that scenario and see what works best for you.

Because I also don't know.

Like, the tezofenzine for me makes me super jittery and a little bit nauseous.

So it's not my favorite personally, although I know people that swear by it and love it.

Cadbury makes me super tired, so I try not to take that on the regular, but I do.

I've taken both of them.

I have used both of them.

My point in saying this is you really have to just figure out what works best for you.

Okay.

Hi, Tara.

I have cycled this is a long one.

I have cycled multiple stats of peptides over the past nine months, beginning with hrt.

Okay, so hormone replacement therapy.

I'm super happy to say that I have slowly and with proper nutrition, exercise, fitness routines, finally lost the excess fat I've been carrying around for 15 years.

Awesome.

I have lost 40 pounds and I'm now approached on a regular basis by women asking what I do to work out and if I compete.

Also amazing.

My question is this.

How do I continue to cycle peptides for the many benefits they offer as far as recovery, immunity, DNA repair, energy, neurological benefits, reduction of cholesterol levels without continuing to lose weight?

Do I just concentrate on increasing my muscle or to balance with weight loss, do I minimize dosing?

Do I do shorter cycles?

Many of the peptides I use have the benefit of weight loss, but I can't really keep losing weight.

Thank you.

Here's what I'll say about that.

Yes, some of these peptides can help help optimize your metabolism and could cause you to lose some weight.

But the GLPs are the main ones.

So if you're on a GLP and you're concerned about losing more weight, get off of it for a while.

You can always cycle back on it.

Like I said earlier, it's got amazing benefits, but I would get off of it for a while.

I don't know which ones you're taking cause you didn't list that.

But Even things like Mot C, 5Amino 1 MQ, AOD, those all help with releasing fat stores and leaning out.

So do the growth hormone secretagogues, but you don't really see significant weight loss with any of those.

They're gonna work on different things.

The MOT C's prime goal is help your mitochondria and give you energy boost.

AOD and 5Amino1MQ give you energy, but also help with stubborn fat, which it sounds like you've had success getting rid of.

So maybe you don't cycle those.

The growth hormone one to be great to help with things like building lean muscle mass and I definitely would focus on that.

But the truth is if you're eating enough protein, your weight should stabilize and you should not be losing weight.

If you're really getting your nutrition where it needs to be, there is a tipping point where your weight will stabilize and you're just not going to lose anymore.

So I don't know.

That would be a giant concern.

If your nutrition truly is in check and when I'll repeat this, the gold standard.

This is My opinion, of course, is trying to get one gram of protein per desired lean body mass.

So if you weigh 140 pounds and you want to say 140 pounds, eat 140 grams of protein, and I can promise you you're probably not going to lose weight.

If you're doing that, you should be able to beautifully maintain it and be very healthy and have great muscle mass and body composition.

But I wouldn't worry so much if you're doing that about the weight loss.

What are your thoughts on methylene blue?

I've heard so many good things about it, especially in women with menopause.

Great question.

So let's talk about what methylene blue is.

It's actually a synthetic compound.

It was originally used as a dye and later adopted in medicine for things that I'm not going to go into.

It is fda, FDA approved for specific blood disorders and it's widely talked about in this longevity and wellness space for its role as a mitochondrial miser, meaning it helps your cells produce more energy, more efficiently.

There is some emerging research that says it can be supportive during menopause because it supports brain clarity by it crosses that blood brain barrier and supports mitochondrial efficiency in the brain cells, which helps with things like brain fog, focus, memory challenges that we often get with these hormone shifts in menopause.

It can also help with energy and fatigue.

It can enhance things like ATP production.

So when we get that perimenopause, menopause, fatigue, it can help with that.

There is some emerging research that suggests that it may influence hypothalamic signaling and neurotransmitters involved in temperature regulation, which I think is super interesting.

This can help with things like hot flashes in some individuals.

So there's a lot of reasons why it's great for women in perimenopause and menopause.

Also with collagen production, there's some research coming out about that.

All the good stuff.

You definitely want to cycle it.

I cycle it.

You want to remain sensitive to it, but you can overshoot the mitochondria and it can start causing more oxidative stress.

And it is.

So it ends up being more harmful than it is productive.

So you definitely want to cycle it for one to three months, followed by a break of a month or two, and then cycle back on.

This also helps prevent tolerance to it.

Be aware that it is a potent MAO inhibitor, so it can dangerously interact with things like ssri.

You want to be really careful about that as well.

But overall I think it's great.

Maybe Something that I end up carrying at some point at the Peptique.

But yeah, I love methylene bloom.

Big fan.

Okay, this question I get a lot.

Can you have wine or alcohol while taking peptides or does it affect it negatively?

Look, I'm not going to be the biggest hypocrite on the planet and tell you that I don't drink wine.

I love a good glass of wine.

I'm not going to lie.

It's probably my biggest flight.

Can it negatively affect peptides?

Absolutely it can.

So let's be honest about that as well.

If you're drinking a couple glasses of wine a week or whatever, you're going to be just fine.

If you're drinking every night, it can wildly inhibit the peptide's ability to be effective.

You can offset that with things like injectable glutathione, which I recommend especially this time of year when you probably are overindulging a little bit.

But when you're putting something that is technically a toxin in your body's gonna focus on removing that toxin and not on the peptides doing their job.

It just blunts the effectiveness of them.

So yeah, definitely something to keep in mind if you wanna get the most out of your peptides.

Other thing I will say is things like GLPs they are finding are having a really positive effect on people that struggle with drinking too much.

And same way that it helps them not eat as much, calms that dopamine activity, that impulse control calms that down, we are finding that it really can help with people that have addiction issues or even just a problematic habit.

Hi Tara, my question is regarding GLPs and RETA specifically.

I know people talk about not cycling GLPs in the same 8 weeks on 8 weeks off cycle, but can you clarify more about what appropriate cycles would look like to keep from being desensitized?

What doses are we talking about when referring to microdosing for non weight loss benefits rather than cycling off?

And can you cycle between higher weight loss doses and micro doses without cycling off at all in order to continue receiving the other benefits?

Thanks so much.

Great question.

Let's back up the first one.

I know people talk about not cycling GLPs in the same 8 week cycle.

Can you clarify more about the appropriate cycles would look like this is a hard one because this is different for everyone.

If you are at your goal weight and you're not on it for weight loss.

I answered a couple of questions in one shot here.

If you haven't reached your goal weight yet, I would say you need to stay on it and not cycle off of it.

But find an effective dose that's working for you at the lowest level and try not to continue to titrate up.

So you may want to add something like a caggery.

I know we're going to be carrying the oral version or of a full prawn.

I'm not saying that, but those of you who know this stuff know what I'm talking about.

I've heard that's been extremely helpful in people breaking through their plateaus, which we will have probably in the next couple weeks.

By the first of the year we'll have in the inventory.

So keep that in mind.

Those hit in a different way so they can come in and be very supportive of people at a plateau without having to increase their GLP dose.

I would stay on it until you get to your goal weight.

If you want to cycle off of it, you can cycle off of it for a couple of months at a time.

Usually people do okay doing that.

Maybe you do a tezofensine or something like that to help with appetite control or oral dlp.

Those are things to consider if you want to stay on a microdose.

I have a love hate relationship with this conversation because it means so many different things, different people, and you're going to hear 25,000 different protocols on how to do this.

And it varies from GLP to glp.

I don't necessarily want to get into what a microdosing protocol looks like.

That's a whole different episode on its own.

But you would break a very low dose up to a couple of times a week, sometimes three times a week.

I've heard of some people doing it every day, although I don't really know about that.

I've also heard about people framing microdosing as well.

I do it every 10 days or every two weeks instead of every week.

So you can see where this conversation isn't super clear cut.

But I would say just on a very low dose where you're not necessarily feeling like the appetite suppression, but it's keeping your inflammation and all that down.

And yes, that's what I do.

I'll stay on a low micro dose, but then I'll titrate back up if I feel like I have some pounds creeping back on or like in the holidays right now where the food noise comes screaming back in because we've got all the cookies and stuff in front of us and so it really helps with that.

So I'll talk back up and then after the new year I'LL go back down.

Some people will not do that and then they've gained five to ten pounds over the holidays or more and they need to titrate up after the first of the year.

My point is, yes, you can play around with this so you can remain sensitive to it and figure out what works best for you.

I feel like that's clear as mud.

I apologize, but it's just not a super straightforward answer for everyone.

You really have to be your own N of one here and figure out what works for you.

Okay?

Regarding the growth hormone peptides, I did an eight week cycle.

I I definitely gained some muscle, which I love, but I also retained a lot of water the entire time and my joints were pretty creaky for weeks after cycling off.

I only went up to 200mcgs for a short time and then stayed at a hundred mcgs for most of my cycle.

I'm wondering if those side effects are just an annoying part that we pushed through or if they signaled that the growth hormone peptides aren't good for my body.

I know my IGF one is already pretty high, so is it possibly dangerous for me to continue to cycle these?

If your IGF is already high and you're getting these side effects that stem from your IGF getting too high, this may not be a good fit for you.

If your IGF got high because of the growth hormones, you just need to stay off of them for a little while.

Some people are more sensitive to the water retention and the creaky joints than others.

I don't get the creaky joints, I definitely get the water retention.

My husband gets the opposite when he takes these, so it really just depends on the individual.

But if you know that your IGF one is already really high, then you might consider skipping this one, unfortunately.

Okay, would love to hear your thoughts on the efficacy of adding certain peptides to the same syringe right before injecting to reduce the amount of needle pricks, and also the efficacy of preloading syringes either before travel or even overnight to save time in the morning.

I don't like preloading syringes at all for a number of reasons, but when you travel it's really not hard to stick a vial in your bag on ice or either unreconstituted and reconstitute it when you get there and put it in your mini fridge or the refrigerator, wherever you're staying.

And it's easier to keep one or two vials cold than multiple syringes cold.

So I think it's easier to travel that way.

But the PH of these things and the way that these work, they're not always compatible.

And so I'm not a big fan of preloading overnight and letting them sit together all night, even if they're known to be safe.

I would say the ones that you can get away with that are more of the healing peptides like the KPVs, the BPCs, the TB5 hundreds.

Some of the other ones like the AODs, the 5Aminos, the NAD, I would not.

So it just gets really complicated really fast.

The other thing I will say is what I do is I will load several things in the syringe at the same time and then inject it immediately if they're not sitting together too long.

Typically speaking, it's okay.

But I load those two in the same syringe and then I immediately inject.

I wouldn't want those loaded and sitting overnight or longer.

It's not super straightforward, but hopefully that gives you a little bit of clarity.

Okay, I microdose semaglutide didn't even go to the starting dose.

I did it for the mental health benefit.

It made my mood more even.

Keel, that's awesome.

I started reta for weight loss and stopped the semaglutide.

I'm currently on 2mg but I do not feel the same mental health benefits from the reta.

I mentioned this to my doctor and she told me to also microdose the sema along with the reta.

What are your thoughts?

You should be getting weight loss off both of these and you probably never got to a high enough dose on the semaglutide in order to lose weight.

I do find that people that have been on semaglutide or tirzepatide have a harder transition over to retatrutide.

I would say try tirzepatide and see if you can kill two birds with one stone, get the mental health benefits you're wanting and lose the weight as opposed to combining both.

When you combine both, there's an overlap of semaglutide, one of the components, and tirzepatide, two of the components.

If you were to overlap it with Reddit, I know people are doing this, but it just seems a little overkill.

If you could take one and get both the benefits you're wanting, that makes more sense to Me.

So maybe talk to your doctor about starting tirzepatide.

Cause I don't know that I would combine semaglutide and itrutide.

Okay, I think I answered this one already.

This is about mixing peptides.

I just answered that.

Cmax, specifically the nasal version.

What are the benefits of this method versus injectable?

I know everyone would love to not poke themselves so much with the needles, but it's just not as bioavailable.

We just added C Max today to the PEPTI collection of products and we're adding CELINK pretty soon.

I immediately got the question, will you be offering the nasal spray?

I probably will just because so many people ask about it.

But if I were going to take that and wanting the maximum benefit out of it because you're already spending the money, I would inject it.

I would not do the nasal spray.

It's just not as good.

There you have it.

I get this question a lot.

How long can you keep Backwater after opening in fridge or cool dark place?

There's a couple of questions here.

Let's start with that one.

The rule of thumb, the gold standard is 28 days past the initial syringe going into the vial.

And I don't necessarily disagree with that.

Have I kept backwater longer than that and used it?

Yes.

I think based on some recent research that's come out, it's best to keep it in the fridge in a dark place.

It just keeps it from having as much opportunity to get microbes and stuff like that in it that could cause problems with the backwater.

Best practice, 28 days in the fridge and dark.

Hopefully that helps answer that.

The next part of that question was how long should you stay on AOD and should you switch cycle with 5amino?

Switch cycle?

I don't know what, I'm not sure what you mean by that, but AOD.

I actually love pairing with 5amino but 8 to 12 weeks on AOD, I had to take a higher dose.

If you get my peptide guide, it says 300mcgs, which is a gold standard.

But again, this is where you have to play around what works for you.

I actually doubled that with the 5amino 1 mq and got great results.

I need to do an episode on that.

But yeah, just for whatever that's worth.

Okay, what peptides need to be refrigerated and which do not all peptides need to be refrigerated?

There's an easy answer.

When to freeze peptides and what do you freeze them in?

You want to freeze peptides?

If they're not reconstituted.

They are reconstituted, meaning you've added the reconstitution solution.

You cannot freeze them, but you can freeze them if they're still in the litholized powder form and that will protect them.

You can store them for years and they will not lose their potency when you put them in the freezer.

And to freeze them, if you're not going to use them within 30 days, go ahead and put the powder though, even if it's unreconstituted and the refrigerator too.

That's just the best practice.

And what do you freeze them in?

I have a plastic peptide vial holder that I put all mine in.

It keeps the light completely off of them and I put them in the freezer that way.

So figured out you can get this on Etsy.

Just get on Etsy and google like peptide bile holder and you'll see what I'm talking about.

I don't know why Etsy's so popular for them, but for some reason they are okay.

Question about desensitization.

Desensitization.

Can't say that today for some reason to GLPs I've heard going off and on and back on or even switching meds can make the second round slash med less effective.

I found this to be personally true for me by switching from Senna to TERS after a four month break and maybe my body less responsive to the ters.

This has made me nervous about potentially switching to Reta in the future.

Is there truth to this?

I know that people have a really hard time switching from SEMA and TERS to Retta.

So I would say if TERS is working for you, just stay on it.

We all talk about Retta like it's the best one out there.

The data shows it's amazing.

But the data is really great on Tirzepatide too.

And the longer I do this the more I'm finding that a lot of people just do better on it.

I don't know that I've heard much about it being less effective if you go back to it after trying a different one.

If I'm being honest, we stay on these things for so long.

You've been on SEMA for a while and now you're on terzepatide.

Your body's been on this so when you first take it you feel super hyper responsive to it but after a while you just don't because it becomes your new normal.

And I find this to be true with a lot of people.

But if you can get to a place where the Tirzepatide is really working well for you.

I don't know that I would make matters more complicated by switching.

That's my personal belief in just working with lots and lots of people and what I've experienced with them.

I would love to talk more about women's hormones, including testosterone dosages, labs, requirements, and access to it.

That's not something that I do, so I'm really not going to go into detail about that.

I used to do all of that, but I certainly do not have access to hormones, nor will I ever have access to hormones.

You really need to work with a functional practitioner who specializes in hormones.

If you're working with a solid functional practitioner that specializes in hormones, they're going to know exactly what labs to get dosages that you will need based on your individual labs.

Without looking at someone's labs, there's no way to say this is the amount you need.

So this is a super complicated question, but, yeah, you need to get with a great functional healthcare provider that specializes in hormones.

Is there any concern about cancer and the CLO ingredients?

I know they say theoretically it could increase cancer cells, but if I'm assuming I do not have any current cancer, is it safe to take?

The truth is that we don't have enough research on this.

If you look at BPC157, which is what I'm assuming you're talking about, there is some concern that it can cause angiogenesis, which, if you have a tumor, could cause that tumor to grow faster.

And so that's where the big concern is.

There's also been research that suggests that BPC157 helps fight cancer and kill cancer.

So we just don't know enough.

I would say.

If you have a lot of cancer history in your family, are you concerned about it at all, then don't risk it.

But that is a very personal choice that you have to make.

There's just not a hundred percent.

Yes, this is the answer.

It's also why it's really important to cycle these things so you're not just staying on them constantly.

Next question, Ellen, without or with dac, why and who is a good candidate?

A lot of people think, I want the longer one?

Actually, no.

The one without DAC pulses more like our natural growth hormone.

It works in a much more natural way with our bodies, which what makes it so beautiful.

And the iparellin has a little bit longer half life, so the two combined work really well synergistically.

The one that stays in your body for a really long time, the one with the dac, that's when you start seeing higher IGF levels, more side effects, that sort of thing.

So I'm personally not a huge fan of that.

I know people like that.

I'm not a huge fan of that.

As far as who's a good candidate, I'm not gonna speak to the with dac, but without dac, if you want better sleep, you want all the benefits of growth hormone release naturally, like better sleep, better hair, better skin, better nails, better muscle synthesis, then you're a good candidate.

The same person also has how do you know when you're ready to move to a GLP3 I don't really know the front end of that question.

I'm gonna skip that one because I'm not really sure what the question is there.

What peptide can help reduce inflammation or combat PCOS?

100% GLP.

I have seen GLPs transform women who have PCOS time and time again.

So if you struggle with pcos, get on a glp, work with someone that can help you navigate through that.

It can be a huge game changer for you.

What peptides can help with and fertility?

Kisspeptin is a good one.

It helps women release the luteinizing hormone and the follicle stimulating hormone, which plays a huge role in estrogen production and fertility.

So that is a really good one to do some research on your own about fertility.

I've seen it help both men and women with fertility issues.

When you have lots of bases to touch, what's a good way to go about mapping out a schedule to keep the overwhelm down?

Sometimes I struggle to sort out which organ or function to pay attention to next.

When everything feels so important, it's a great question.

I always say focus on your goal.

What is your number one goal?

If energy is your goal, focus on mitochondrial support.

If you're really struggling with energy, I would start with an SS31, then move on to maybe a MOT C or a MOT C N a D cycle.

People think we have to do all these at one time.

You may be able to layer in the background a CLO if you have an injury.

Those work on different things.

So I often tell People, let's get your energy started.

Let's start you on an SS31.

Let's start to get you healed.

Maybe start you on the background on glow.

If you skin rejuvenation or just GHKCU on its own.

Skin rejuvenation.

Here's the, here's a double edged sword here.

GHKC.

If you've got a lot of mitochondrial issues and you're working on the gene expression that GHKCU has, sometimes you might get a little bit of overlap and get some fatigue and stuff like that with that.

So you just have to be careful and take things very.

I always like to start to get people very metabolically healthy, maybe a glp.

Then let's focus on your energy.

Oftentimes if we get you metabolically stable, your energy is going to naturally increase.

Then let's work on the mitochondrial peptides or some of my.

You're finding that you have more energy, you've leaned out some.

Now let's layer in growth hormone peptides to help with the body composition aspect because now you've lost the weight and now you have the energy to be in the gym which is going to make those growth hormone peptides, the Tesmorel and Ipinerell and CJC even more effective because you're going to get better workouts.

And if you start to see the trend of where I'm going, you can have maybe something like the GLOW or GHKC going on in the background to help with skin rejuvenation repair, that sort of thing.

So it's not a one size fits all.

Definitely something you have to figure out for yourself.

But stay very goal focused and then cycle through your goals.

I took Thymosin Alpha 1 to boost my immune system increase neutrophils, but it didn't work.

I guess in theory it can work on that, but that's not exactly what it does.

So maybe it's not too surprising that you didn't see a huge shift there.

I don't really know of something else at the top of my head that would work for that if I'm being honest.

Let's see what happens to the body when coming off ratatrutide.

Does late weight loss come back even if maintaining optimal eating habits?

Yes, it very well.

Could I tell people to start looking at the GLPs a little bit differently?

Think of hormone replacement therapy.

As we get older our hormones start to decline.

So we give ourselves hormones in order to optimize our hormones like they were when we were younger.

So you get all the benefits of what that means.

GLPs are no different.

Our insulin sensitivity or insulin resistance.

How our body regulates our blood glucose level and our insulin levels declines as we get older.

So when you give yourself a glp, you're telling your body to perform in a very optimized way.

Whether you've got some more severe metabolic stuff going on or it's just the sign of aging.

If you strip yourself of the hormones you've been taking, what happens?

Your hormones tank and you get all the side effects back.

It's not any different with GLPs.

You want to hit your certain goals with it and then find a maintenance dose or cycle often on it.

But I do find when people start to cycle off and on it, you're more than likely at some point in time, you're going to see the weight creep back on, even if you're perfect with your diet and exercise.

Not because you're not doing all the right things, because your body can't respond metabolically the way it did when it was younger.

Okay, I'm sorry.

I'm trying to get through maybe some bigger questions.

What are your thoughts on injecting pens versus syringes?

I don't have one.

They both work.

Figure out what works best for you.

Also, are the same peptides you could stack with the same serendipant.

We talked a little bit about that.

I'm not gonna do that.

Can you microdose epitalin longer than a month?

I know people cycle off and on, but what are the consequences of not cycling off?

You don't wanna do that.

You wanna cycle off for sure.

Because epitalin works by signaling the body's longevity and repair pathways, particularly around telomeres and the circadian rhythm.

So because it's a signaling peptide, it's not meant to be run continuously.

Staying on long term can blunt the signal and reduce responsiveness.

You definitely want to cycle.

There's no benefit to staying on it past that.

Also tried oxytocin at 10 units.

Got the worst cramps I've ever had.

Is there a way around this?

I don't know what 10 units mean.

So when y' all send me questions in the future, don't send me units.

Send me mcgs or milligrams.

That's how I know what you're actually taking.

I will say, if you're dosing according to the protocol guide, the recommended dose is 5 units, I believe just takes a tiny amount of that oxytocin.

I took too much once and got the worst headache ever.

So we really aren't meant to take more.

The way to get around that is take less.

Hopefully that answers that I'm really trying to get through all these y'.

All.

I just started listening to your podcast today.

I'm wondering if most peptides need to be cycled.

Yes they do.

If you want to know the cycles, shoot me an email and I will send you my peptide guide.

Okay, cjc.

Yes for sure.

GHKCU is not a classic on off signaling peptide and so a lot of people say you can take it long term.

I don't do that.

I just like to cycle through these things.

That being said, if you are staying on it long term, you definitely want to take a zinc.

Hey, I always say that wrong.

Sounds like I'm saying pickle, but you guys know what I mean.

About 15 milligrams if you're going to stay on it because the two need to be in balance to work effectively.

You don't want to waste the peptide.

Normally if you're taking a good multivitamin you're going to have about 15 milligrams of that zinc in there.

But if you're not, just get one separately.

If you are on Retta and Tess Morlin and slowly go off them, but continue your weight lifting cardio health eating lifestyle, do you gain your weight back?

Yes, most people do and I answered why?

I know.

I wish I could tell you they don't, but in my experience most people do.

I'm looking for some guidance on scalp psoriasis.

I only break out on my scalp and on my hairline.

Moisture is my enemy.

If I sweat or allow my hair to air dry, I'm guaranteed to break out.

You said you tried the topical KPV but it didn't work.

You thought made it worse.

Sometimes it can make the initial thing worse as your body's responding to it and then it actually does work.

My son had something similar and I ended up taking him to a dermatologist and I did scraping to figure out what it was and it ended up being more of a fungus that's really hard to kill by your typical things.

So you may need to get an antifungal, a topical medication that might actually be a real game changer because he was the exact same way Broke out the exact same way that you're talking about.

You could try a GHKCU topical, that might work more efficiently.

I want to know if anyone who is on Ozempic has added a peptide or stack to aid in weight loss.

I am a type 2 diabetic on Ozempic for three years now.

No major weight loss.

Just want to start to kick slash boost to help in that area.

I'm going to add caglantide to my regimen.

Okay.

I would recommend try Tirzepatide because of all the reasons I just mentioned.

You may struggle more with that one.

But the fact that you've had no weight loss on Ozempic makes me think Ozempic just is a.

It's just like sema.

It is semaglutide so it's only hitting one of the components.

Tirzepatide hits two and then retatrutide hits three.

If you can get your insurance to pay for it cuz you're a type 2 diabetic because RET is not out yet, I would definitely switch to Tirzepatide before adding cadentide and see if that helps you lose weight.

Okay.

In a hypothetical scenario where GLPs are no longer available in the research peptide space, let's pray that didn't happen.

Which peptides would you recommend as possible replacement for fat loss?

Appetite suppression?

I was thinking Tessa Calgary.

Tessa Calgary, tessamorelin, Gabrilantide and aod.

But I know that there are other tools like L Carnitine we use as well also.

Are there any of these that you would not recommend me take at the same time or just cycle at different times?

Okay, I'm gonna try to answer this quickly.

The.

The Olaforpron.

I'm so butchering that.

But this oral version could be a real game changer.

So that potentially be something super helpful in this scenario if that does happen.

This other ones that you mentioned really aren't weight loss peptides.

Lentite can help with appetite control, but if the GLPs go away, the cap or lenti is probably gonna go away too.

So that oral form's gonna be a good fit and possibly something like Tesafenzine.

Tesamorelin is not a weight loss one.

AOD is not a weight loss one.

Maybe those other ones I mentioned would be better fits.

Ipamorelin, DAC or no dac, I think.

How do we choose?

Ipamorelin doesn't have Jack.

I heard you discuss NAD plus MOT C5Amino in context of fatigue.

Oh gosh.

This is a long question.

Really caught my attention.

I'm 43 post hysterectomy.

The tiredness and emotions can be debilitating at times.

I know you can't give individualized medical advice.

No, I cannot.

But I'd love general guidance.

If someone was pointing me towards first steps framework, what would that be?

Okay, I'm going to do a podcast on this pretty soon from personal experience about ADD or adhd.

And I would do nad.

It helped me get off ADHD medication that I had been on for years and years.

And it's also I've seen people that I've worked with.

It helped them.

So that would be the first place I would start.

Cause it'll also help with energy and mental clarity and focus.

There are other ones like Dihexa, things like that too.

But the nad, at least in my experience, I know that really works.

So that would be your first step because that one of the questions you ask.

Are there specific episodes resources you recommend?

Not currently on that, but like I said, it's on my list of episodes I want to do.

And when you say get blood work done, what lab markers do you think are best baseline for fatigue, perimenopause and overall health?

With a clinician?

Get with a functional practitioner that will run a will run a functional blood work panel that's going to be full thyroid, full hormones, all the things they're going to look at.

Inflammation markers like C reactive protein, homocysteine, methylmalonic acid to see how you are methylating your B vitamins.

Start there.

It's not just get these five markers, it's like a hundred markers that you really want to look at and see where you're at.

Also look at deficiencies like magnesium, vitamin D, potassium imbalance, iron, ferritin, all that can be a big play.

It can be big culprits in what's potentially going on.

Get with a good functional practitioner who will run those full panels on you.

Okay.

This person had a properly read a hundred unit syringe and mcgs versus mgs.

I remember this was very confusing for me in the beginning as well.

And I think you mentioned you got confused when you saw the dosing and mcgs on the chart.

That's because mcgs are usually used for anything that's under 1 milligram.

So if you're seeing anything that is an MCG format, think of that as under 1 milligram.

Most people refer to these things as under 1 milligram in the MCG version.

Hopefully that helps clarify that.

I am late to this.

If this has already been asked and answered.

Can you safely take alternating microdoses of ters and retta?

What would be some of the risk and benefits?

What would appropriate dosing look like?

Not gonna speak to dosing on this because it's so different for everyone.

I don't know what you've been taking.

I don't know how that's been working for you.

Yes, I have heard of people.

I've never done it myself.

I have heard of people alternating, like maybe one week doing TERs and the next week doing reta because they want that appetite control from the ters, but they want the fat burner, glucagon element of the retta.

I don't think there's any harm in doing that, but you just need to see how you feel.

I did do an episode recently about how retta can really have your HRV tank can cause sleep problems.

Definitely.

I would say take taurine again if you're going to do that.

And yeah, that's all I'm going to say about that.

I don't think there's a ton of risk.

I definitely don't like the idea of taking this both at the same time, which I've heard people doing, because there's too much overlap, in my opinion.

But I don't think there's any real risks to it.

So I can throw that out there.

Okay, last question.

Here we go, folks.

This is not a peptide, and you may not want to touch this topic.

I love questions that start like that.

But what do you think about nicotine as a nootropic and neuroprotective substance?

There is very little info about it that isn't one extreme or the other.

I'm not talking about smoking or vaping, which is absolutely very bad.

Just nicotine alone.

Great question.

I think for some people, it's really great.

I know a lot of people, if you're not overdoing it.

I'm going to totally wrap my husband out here because he always has a nicotine pouch in his gum.

It's just something that he started doing when he was young and I got him off the tobacco part of it.

So that was our happy medium there.

And he constantly has one in.

Am I a fan of that?

Absolutely.

Not microdosing it.

And I don't know off the top of my head what a microdose would be, but doing a couple hits of a little nicotine tablet, you can put them under the tongue or whatever, I think is totally fine from the information that I know.

Don't send me a bunch of emails, please do your own research.

I have actually tried this myself and it made me feel terrible.

My brain chemistry does not work with that type of thing.

But I have talked with probably thousands of people that say how great it is and how much they love it and how it really gets them through their day and helps them focus.

So try it and see if it works for you just like everything else in moderation.

If you find that you're overdoing it, because I do think it can be addictive.

If you're one of these people that has a very addictive nature, then maybe stay away from it.

You don't need to add another vice.

But if you're someone that just wants a little boost here and there throughout the day, then, yeah, don't think there's anything wrong with it.

And there's a lot of emerging research saying that it can actually be good for you.

So we will end with that controversial note and y' all I went over, but I really wanted to get through all these questions.

I'm so grateful for all of them.

I'm hoping to do this once a month, if not every other month, depending on how many questions I get in.

And I just wish you and yours the merriest Christmas ever.

And that we focus on what the true meaning of Christmas is.

And that's the birth of Christ.

We spend time with our loved ones, family and friends, and take a step back, take a breather, and enjoy some downtime.

So if you don't hear from me between now and the new year, I'm working on new episodes.

I might be able to squeeze one more out.

Go share this podcast.

Go sign up on the Peptique website with your email.

I'll also put a little link in the jot form.

Go follow me on Instagram that y' all support in those areas.

I cannot even tell you.

That really helps me continue to do the things that I love to do and share all this information with y'.

All.

There's also a link to the Women's Peptide Collective.

If you haven't heard me talk about it at nauseam.

This is a group strictly for women to talk about all the things Peptide related.

It's totally free.

I'll put the link on the website there.

I try to be as responsive as I can.

There's some new things coming out this year where I'm hoping to do maybe some live type of calls or something like that.

We'll see.

So Merry Christmas and until next time, y' all have a blessed day.